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ChemicalBook > Product Catalogue >Biochemical Engineering >Plant extracts >Rhein

Rhein

Rhein Structure
  • ₹10700 - ₹62806.65
  • Product name: Rhein
  • CAS: 478-43-3
  • MF: C15H8O6
  • MW: 284.22
  • EINECS:207-521-4
  • MDL Number:MFCD00009618
  • Synonyms:chrysazin-3-carboxylicacid ;monorhein ;rheicacid ;RHUBARB YELLOW;RHEIN;TIMTEC-BB SBB001152;1,8-DIHYDROXY-9,10-ANTHRAQUINONE-3-CARBOXYLIC ACID;1,8-dihydroxy-3-carboxyanthraquinone
Price9 Properties Safety Information Description
9 prices
Selected condition：

Brand

  • TCI Chemicals (India)
  • ALFA India
  • Sigma-Aldrich(India)

Package

  • 10MG
  • 50MG
  • 200MG
  • 250mg
  • 1G
  • ManufacturerTCI Chemicals (India)
  • Product numberD3986
  • Product description4,5-Dihydroxyanthraquinone-2-carboxylic Acid
  • Packaging200MG
  • Price₹10700
  • Updated2022-05-26
  • Buy
  • ManufacturerALFA India
  • Product numberALF-H60902-MD
  • Product descriptionRhein, 97%
  • Packaging250mg
  • Price₹11467
  • Updated2022-05-26
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product number275611
  • Product descriptionRhein technical grade
  • Packaging50MG
  • Price₹11929.15
  • Updated2022-06-14
  • Buy
  • ManufacturerTCI Chemicals (India)
  • Product numberD3986
  • Product description4,5-Dihydroxyanthraquinone-2-carboxylic Acid
  • Packaging1G
  • Price₹18400
  • Updated2022-05-26
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberR7269
  • Product descriptionRhein
  • Packaging10MG
  • Price₹18932.93
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product number30873
  • Product descriptionRhein analytical standard
  • Packaging10MG
  • Price₹29075.95
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product number275611
  • Product descriptionRhein technical grade
  • Packaging250MG
  • Price₹34282.78
  • Updated2022-06-14
  • Buy
  • ManufacturerALFA India
  • Product numberALF-H60902-03
  • Product descriptionRhein, 97%
  • Packaging1g
  • Price₹35429
  • Updated2022-05-26
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberR7269
  • Product descriptionRhein
  • Packaging50MG
  • Price₹62806.65
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
TCI Chemicals (India) D3986 4,5-Dihydroxyanthraquinone-2-carboxylic Acid 200MG ₹10700 2022-05-26 Buy
ALFA India ALF-H60902-MD Rhein, 97% 250mg ₹11467 2022-05-26 Buy
Sigma-Aldrich(India) 275611 Rhein technical grade 50MG ₹11929.15 2022-06-14 Buy
TCI Chemicals (India) D3986 4,5-Dihydroxyanthraquinone-2-carboxylic Acid 1G ₹18400 2022-05-26 Buy
Sigma-Aldrich(India) R7269 Rhein 10MG ₹18932.93 2022-06-14 Buy
Sigma-Aldrich(India) 30873 Rhein analytical standard 10MG ₹29075.95 2022-06-14 Buy
Sigma-Aldrich(India) 275611 Rhein technical grade 250MG ₹34282.78 2022-06-14 Buy
ALFA India ALF-H60902-03 Rhein, 97% 1g ₹35429 2022-05-26 Buy
Sigma-Aldrich(India) R7269 Rhein 50MG ₹62806.65 2022-06-14 Buy

Properties

Melting point :≥300 °C (lit.)
Boiling point :346.72°C (rough estimate)
Density :1.3269 (rough estimate)
refractive index :1.4413 (estimate)
storage temp. :2-8°C
solubility :DMSO (Slightly), Methanol (Slightly)
pka :3.17±0.20(Predicted)
form :Solid
color :Yellow to Dark Orange
Water Solubility :<0.1 g/100 mL at 17 ºC
λmax :432nm(MeOH)(lit.)
Merck :14,8176
BRN :2222155
Stability :Hygroscopic
InChIKey :FCDLCPWAQCPTKC-UHFFFAOYSA-N
LogP :4.290 (est)
CAS DataBase Reference :478-43-3(CAS DataBase Reference)
EPA Substance Registry System :2-Anthracenecarboxylic acid, 9,10-dihydro-4,5-dihydroxy-9,10-dioxo- (478-43-3)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P271 Use only outdoors or in a well-ventilated area.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Rhein is an anti-inflammatory anthraquinone found in rhubarb and is the bioactive derivative of its prodrug diacerein . At 10 μM, rhein inhibits IL-1β signaling, suppressing signaling through NF-κB, and reduces the expression of the matrix metalloproteases MMP-1 and MMP-13. It inhibits IKKβ (IC50 = 11.8 μM), decreasing iNOS and IL-6 expression in LPS-stimulated macrophages but paradoxically increasing TNF-α, IL-1β, and HMBG1 expression. Rhein shows efficacy against pancreatic fibrosis, chronic pancreatitis, and hyperglycemia-induced pancreatic β-cell apoptosis. It also inhibits angiogenesis of breast cancer cells under normoxic and hypoxic conditions.

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Suppliers and manufacturers

Siddhivinayakchemicals A.J Chemicals CLEARSYNTH LABS LTD. CHEMSWORTH TCI Chemicals (India) Pvt. Ltd. Alfa Aesar SynZeal Research Pvt Ltd Pharmaffiliates Analytics and Synthetics P. Ltd Nilkanth Organics Reax Chemicals