SB218078
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- ₹19050
- Product name: SB218078
- CAS: 135897-06-2
- MF: C24H15N3O3
- MW: 393.39
- EINECS:
- MDL Number:MFCD27991263
- Synonyms:9,10,11,12-Tetrahydro-9,12-epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-1,3(2H)-dione;SB218078 ?SB-218078;9,12-Epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-1,3(2H)-dione, 9,10,11,12-tetrahydro-
1 prices
Selected condition:
Brand
- Sigma-Aldrich(India)
Package
- 1MG
- ManufacturerSigma-Aldrich(India)
- Product number559402
- Product descriptionSB 218078 - CAS 135897-06-2 - Calbiochem A cell-permeable, ATP-competitive, and reversible indolocarbazole derivative that acts as a potent and selective inhibitor of checkpoint kinase (Chk1)
- Packaging1MG
- Price₹19050
- Updated2022-06-14
- Buy
Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|
Sigma-Aldrich(India) | 559402 | SB 218078 - CAS 135897-06-2 - Calbiochem A cell-permeable, ATP-competitive, and reversible indolocarbazole derivative that acts as a potent and selective inhibitor of checkpoint kinase (Chk1) | 1MG | ₹19050 | 2022-06-14 | Buy |
Properties
Melting point :>340 °C
Density :1.80±0.1 g/cm3(Predicted)
storage temp. :Store at RT
solubility :≤5mg/ml in DMSO;5mg/ml in dimethyl formamide
form :crystalline solid
pka :9.75±0.20(Predicted)
color :Light yellow to yellow
Density :1.80±0.1 g/cm3(Predicted)
storage temp. :Store at RT
solubility :≤5mg/ml in DMSO;5mg/ml in dimethyl formamide
form :crystalline solid
pka :9.75±0.20(Predicted)
color :Light yellow to yellow
Safety Information
Symbol(GHS): |
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Description
SB 218078 is an inhibitor of checkpoint kinase 1 (Chk1) that blocks phosphorylation of cdc25 with an IC50 value of 15 nM. It less potently inhibits cdc2 and PKC (IC50s = 250 and 1,000 nM, respectively) and causes 85% inhibition of PKD1 at 1 μM. SB 218078 releases G2 cell cycle arrest induced by γ-irradiation or the topoisomerase I inhibitor topotecan . In this way, SB 218078 enhances the cytotoxicity of DNA-damaging compounds.More related product prices
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