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Sodium tolmetin dihydrate

Sodium tolmetin dihydrate Structure
  • ₹0
  • Product name: Sodium tolmetin dihydrate
  • CAS: 64490-92-2
  • MF: C15H14NO3.Na.2H2O
  • MW: 315.3
  • EINECS:626-708-5
  • MDL Number:MFCD00150761
  • Synonyms:sodiumtolmetindihydrate ;tolmetinsodiumdihydrate ;1-methyl-5-(p-toluoyl)pyrrole-2-acetic acid sodium-potassium salt dihydrate;TOLMELINSODIUM;Tolmetinsodiumsaltdihydratecrystalline;1-Methyl-5-(4-methylbenzoyl)-1H-pyrrole-2-acetic Acid Sodium Dihydrate;1-Methyl-5-p-toluoylpyrrole-2-acetic Acid Sodium Dihydrate;5-[(p-Tolyl)carbonyl]-1-methylpyrrole-2-acetic Acid Sodium Dihydrate
Manufacturer Product number Product description Packaging Price Updated Buy

Properties

Melting point :155-157 (dec.)
storage temp. :-20°C Freezer
solubility :Methanol (Slightly), Water (Slightly)
form :Solid
color :White to Beige
Water Solubility :Soluble in water
InChIKey :QQILXENAYPUNEA-UHFFFAOYSA-M
CAS DataBase Reference :64490-92-2(CAS DataBase Reference)

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
Precautionary statements:
P202 Do not handle until all safety precautions have been read and understood.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P308+P313 IF exposed or concerned: Get medical advice/attention.

Description

Tolmetin is a non-steroidal anti-inflammatory drug that non-selectively inhibits human COX-1 and -2 with IC50 values of 0.35 and 0.82 μM, respectively. It also inhibits aldo-keto reductases (e.g., IC50 = 2.39 μM for human aldose reductase), a family of enzymes that catalyze the NADPH-dependent reduction of carbonyl groups in a number of important steroid, metabolic, and prostanoid molecules.

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