Synephrine hydrochloride
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- ₹0
- Product name: Synephrine hydrochloride
- CAS: 5985-28-4
- MF: C9H14ClNO2
- MW: 203.67
- EINECS:227-804-6
- MDL Number:MFCD00050566
- Synonyms:1-(4-Hydroxyphenyl)-2-(methylamino)-ethanol hydrochloride;4-hydroxy-alpha-((methylamino)methyl)-benzenemethanohydrochloride ;l-1-p-hydroxyphenyl-2-methylamino-1-ethanolhydrochloride ;p-hydroxy-alpha-((methylamino)methyl)-benzylalcohohydrochloride ;p-hydroxy-alpha-(methylaminomethyl)benzylalcoholhydrochloride ;p-methylaminoaethanolphenolhydrochlorid ;SYNEPHRINE HCL;SYNEPHRINE HYDROCHLORIDE
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Properties
Melting point :147-150°C
storage temp. :Refrigerator
solubility :Methanol (Slightly), Water (Slightly)
form :Solid
color :Off-White to Pale Beige
InChI :InChI=1S/C9H13NO2.ClH/c1-10-6-9(12)7-2-4-8(11)5-3-7;/h2-5,9-12H,6H2,1H3;1H
InChIKey :COTCEGYSNTWJQV-UHFFFAOYSA-N
SMILES :C1(=CC=C(O)C=C1)C(O)CNC.Cl
LogP :-0.030 (est)
CAS DataBase Reference :5985-28-4(CAS DataBase Reference)
storage temp. :Refrigerator
solubility :Methanol (Slightly), Water (Slightly)
form :Solid
color :Off-White to Pale Beige
InChI :InChI=1S/C9H13NO2.ClH/c1-10-6-9(12)7-2-4-8(11)5-3-7;/h2-5,9-12H,6H2,1H3;1H
InChIKey :COTCEGYSNTWJQV-UHFFFAOYSA-N
SMILES :C1(=CC=C(O)C=C1)C(O)CNC.Cl
LogP :-0.030 (est)
CAS DataBase Reference :5985-28-4(CAS DataBase Reference)
Safety Information
Symbol(GHS): |
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Description
(±)-Synephrine is an alkaloid with vasoconstrictor and metabolic activities. It binds to α1A-, α2A-, and α2C-adrenergic receptors (ARs; Kis = 78, 36.7, and 24.4 μM, respectively). (±)-Synephrine is an agonist of α1A-ARs in HEK293 cells (EC50 = 4 μM in a reporter assay) but not in CHO cells expressing α2A- or α2C-AR. It also acts as an antagonist of α1A-, α2A-, and α2C-ARs, inhibiting L-phenylephrine-induced activation of α1A-AR in HEK293 cells and activation of α2A- and α2C-ARs induced by the α2-AR agonist medetomidine in CHO cells (IC50s = 12.8, 26, and 27.3 μM, respectively, in reporter assays). (±)-Synephrine induces contractions in isolated rabbit aortic rings (EC50 = 6.2 μg/ml) and increases ligation-induced mean arterial pressure in rats when administered at a dose of 2 mg/kg per day. It induces lipolysis in isolated rat and human adipocytes when used at concentrations of 100 and 1,000 μg/ml. (±)-Synephrine (50 μM) increases phosphorylation of Akt and AMP-activated protein kinase (AMPK) and translocation of Glut4 to the plasma membrane, as well as increases insulin-induced glucose consumption in L6 muscle cells when used at concentrations ranging from 25 to 200 μM.More related product prices
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Suppliers and manufacturers
A.J Chemicals
CLEARSYNTH LABS LTD.