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ChemicalBook > Product Catalogue >Analytical Chemistry >Standard >Food and cosmetics standards >T-2 TOXIN

T-2 TOXIN

T-2 TOXIN Structure
  • ₹51711.03 - ₹63919.8
  • Product name: T-2 TOXIN
  • CAS: 21259-20-1
  • MF: C24H34O9
  • MW: 466.53
  • EINECS:244-297-7
  • MDL Number:MFCD00871255
  • Synonyms:4β,15-Diacetoxy-8α-(3-Methylbutyryloxy)- 12,13-epoxytrichothec-9-en-3α-ol;8α-(3-Methylbutyryloxy)-4β,15- diacetoxyscirp-9-en-3α-ol;T-2 LienoMycin;T-2 Toxin, froM FusariuM tricinctuM;12,13-epoxytrichothec-9-ene-3-alpha,4-beta,8-alpha,15-tetrol4,15-diacetate8 ;12,13-trichothecene ;3alpha-Hydroxy-4beta,15-diacetoxy-8alpha(3-methylbutyryloxy)-12,13-epoxy-trichothec-9-ene;3alpha-hydroxy-4beta-15-diacetoxy-8alpha-(3-methylbutyryloxy)-12,13-epoxy-delt
Price2 Properties Safety Information Description
2 prices
Selected condition：

Brand

  • Sigma-Aldrich(India)

Package

  • 5MG
  • 2ML
  • ManufacturerSigma-Aldrich(India)
  • Product number33947
  • Product descriptionT-2 Toxin reference material
  • Packaging5MG
  • Price₹51711.03
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product number34071
  • Product descriptionT2-Toxin solution 100?μg/mL in acetonitrile, analytical standard
  • Packaging2ML
  • Price₹63919.8
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) 33947 T-2 Toxin reference material 5MG ₹51711.03 2022-06-14 Buy
Sigma-Aldrich(India) 34071 T2-Toxin solution 100?μg/mL in acetonitrile, analytical standard 2ML ₹63919.8 2022-06-14 Buy

Properties

Melting point :151.5℃
alpha :D26 +15° (c = 2.58 in ethanol)
Boiling point :489.35°C (rough estimate)
Density :1.1942 (rough estimate)
refractive index :1.6230 (estimate)
Flash point :2 °C
storage temp. :−20°C
solubility :DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS(pH7.2) (1:1): 0.5 mg/ml; Ethanol: 20 mg/ml
form :powder
pka :13.24±0.70(Predicted)
color :white
Merck :13,9872
IARC :3 (Vol. 31, Sup 7) 1987

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
Precautionary statements:
P262 Do not get in eyes, on skin, or on clothing.
P280 Wear protective gloves/protective clothing/eye protection/face protection.

Description

T-2 toxin is a common trichothecene mycotoxin produced by Fusarium species, which can infect grain crops causing alimentary toxic aleukia in humans and animals. It triggers a ribotoxic response through its high binding affinity to peptidyl transferase, which is an integral part of the 60S ribosomal subunit, resulting in activation of JNK/p38 MAPKs, interferes with the metabolism of membrane phospholipids, and increases liver lipid peroxides. T-2 toxin is highly cytotoxic to macrophages, inducing apoptosis in primary porcine alveolar macrophage cells with an IC50 value of 19.47 nM. At 3 nM it decreases the production of inflammatory mediators (IL-1β, TNFα, and nitric oxide), TLR4, and TLR2/6 agonists.

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