TUNICAMYCIN
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- ₹5585.7 - ₹93343.98
- Product name: TUNICAMYCIN
- CAS: 11089-65-9
- MF: C37H60N4O16
- MW: 816.89
- EINECS:601-012-4
- MDL Number:MFCD00065709
- Synonyms:Aids010655;Aids-010655;Nsc177382;TunicaMycin froM StreptoMyces lysosuperficus;TunicaMycin coMplex;InSolution? Tunicamycin,;TUNICAMYCIN, STREPTOMYCES IYSOSUPERFICUS;TUNICAMYCIN, STREPTOMYCES LYSOSUPERFICUS
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- Sigma-Aldrich(India)
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- 1MG
- 5MG
- 10MG
- 50MG
- 1ML
- ManufacturerSigma-Aldrich(India)
- Product numberT7765
- Product descriptionTunicamycin from Streptomyces sp.
- Packaging50MG
- Price₹93343.98
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product number654380
- Product descriptionTunicamycin, Streptomyces lysosuperficus - CAS 11089-65-9 - Calbiochem Tunicamycin, Streptomyces lysosuperficus, CAS 11089-65-9, is a nucleoside antibiotic that inhibits N-linked glycosylation and blocks the formation of
- Packaging50MG
- Price₹56200
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberT7765
- Product descriptionTunicamycin from Streptomyces sp.
- Packaging10MG
- Price₹31706.43
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product number654380
- Product descriptionTunicamycin, Streptomyces lysosuperficus - CAS 11089-65-9 - Calbiochem Tunicamycin, Streptomyces lysosuperficus, CAS 11089-65-9, is a nucleoside antibiotic that inhibits N-linked glycosylation and blocks the formation of
- Packaging10MG
- Price₹23150
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberT7765
- Product descriptionTunicamycin from Streptomyces sp.
- Packaging5MG
- Price₹17341.65
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberSML1287
- Product descriptionTunicamycin Ready Made Solution 5?mg/mL in DMSO, from Streptomyces sp.
- Packaging1ML
- Price₹17077.2
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberT7765
- Product descriptionTunicamycin from Streptomyces sp.
- Packaging1MG
- Price₹5585.7
- Updated2022-06-14
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | T7765 | Tunicamycin from Streptomyces sp. | 50MG | ₹93343.98 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 654380 | Tunicamycin, Streptomyces lysosuperficus - CAS 11089-65-9 - Calbiochem Tunicamycin, Streptomyces lysosuperficus, CAS 11089-65-9, is a nucleoside antibiotic that inhibits N-linked glycosylation and blocks the formation of | 50MG | ₹56200 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | T7765 | Tunicamycin from Streptomyces sp. | 10MG | ₹31706.43 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 654380 | Tunicamycin, Streptomyces lysosuperficus - CAS 11089-65-9 - Calbiochem Tunicamycin, Streptomyces lysosuperficus, CAS 11089-65-9, is a nucleoside antibiotic that inhibits N-linked glycosylation and blocks the formation of | 10MG | ₹23150 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | T7765 | Tunicamycin from Streptomyces sp. | 5MG | ₹17341.65 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | SML1287 | Tunicamycin Ready Made Solution 5?mg/mL in DMSO, from Streptomyces sp. | 1ML | ₹17077.2 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | T7765 | Tunicamycin from Streptomyces sp. | 1MG | ₹5585.7 | 2022-06-14 | Buy |
Properties
Melting point :234-235℃ (decomposition)
alpha :D20 +52° (c = 0.5 in pyridine)
Flash point :87℃
storage temp. :2-8°C
solubility :Soluble in methanol, ethanol, DMSO, or DMF
form :White to off-white solid
color :White
Sensitive :Moisture & Light Sensitive
BRN :6888090
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
InChIKey :YJQCOFNZVFGCAF-WPTOCQRYSA-N
EPA Substance Registry System :Tunicamycin (11089-65-9)
alpha :D20 +52° (c = 0.5 in pyridine)
Flash point :87℃
storage temp. :2-8°C
solubility :Soluble in methanol, ethanol, DMSO, or DMF
form :White to off-white solid
color :White
Sensitive :Moisture & Light Sensitive
BRN :6888090
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
InChIKey :YJQCOFNZVFGCAF-WPTOCQRYSA-N
EPA Substance Registry System :Tunicamycin (11089-65-9)
Safety Information
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| Signal word: | Danger | ||||||||||||||
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Description
N-linked glycosylation is a highly regulated post-translational modification that is involved in protein folding and conformation, oligomerization, sorting, cell-cell interactions, and targeting of proteins to sub- or extra-cellular locations. It is initiated in the endoplastic reticulum with the transfer of a carbohydrate moiety to an asparagine residue within a specific amino acid consensus sequence and then further processed in the Golgi whereupon a mature glycoprotein is exported through the secretory machinery to the plasma membrane. Tunicamycin, a nucleoside antibiotic, is a specific inhibitor of N-linked glycoslylation that blocks the first step of glycoprotein synthesis thereby inducing protein unfolding. At 500 nM, it can impair the function of several receptor tyrosine kinases, including EGFR, ErbB2, ErbB3, and IGF-IR. Also at 500 nM, it radiosensitizes U251 glioma and BXPC3 pancreatic adenocarcinoma cells to chemotherapy. Tunicamycin impairs ALK phosphorylation and disrupts pro-survival signaling and cell viability in various neuroblastoma cell lines (IC50s range from 20 - 500 nM). Tunicamycin can also inhibit protein palmitoylation.Related product price
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