Tranilast
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- ₹8800 - ₹64029.88
- Product name: Tranilast
- CAS: 53902-12-8
- MF: C18H17NO5
- MW: 327.33
- EINECS:
- MDL Number:MFCD00864787
- Synonyms:2-((3-(3,4-dimethoxyphenyl)-1-oxo-2-propenyl)amino)-benzoicaci ;n-(3,4-dimethoxycinnamoyl)-anthranilicaci ;n-5’ ;rizaben ;SB-252218;N-(3',4'-DIMETHOXYCINNAMOYL)ANTHRANILIC ACID;2-[[3-(3,4-DIMETHOXYPHENYL)-1-OXO-2-PROPENYL]AMINO] BENZOIC ACID;TRANILAST
4 prices
Selected condition：
Brand
- TCI Chemicals (India)
- Sigma-Aldrich(India)
Package
- 10MG
- 50MG
- 1G
- 5G
- ManufacturerTCI Chemicals (India)
- Product numberT2935
- Product descriptionTranilast
- Packaging1G
- Price₹8800
- Updated2022-05-26
- Buy
- ManufacturerTCI Chemicals (India)
- Product numberT2935
- Product descriptionTranilast
- Packaging5G
- Price₹19500
- Updated2022-05-26
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberT0318
- Product descriptionTranilast ≥98% (HPLC), powder
- Packaging10MG
- Price₹19095.3
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberT0318
- Product descriptionTranilast ≥98% (HPLC), powder
- Packaging50MG
- Price₹64029.88
- Updated2022-06-14
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| TCI Chemicals (India) | T2935 | Tranilast | 1G | ₹8800 | 2022-05-26 | Buy |
| TCI Chemicals (India) | T2935 | Tranilast | 5G | ₹19500 | 2022-05-26 | Buy |
| Sigma-Aldrich(India) | T0318 | Tranilast ≥98% (HPLC), powder | 10MG | ₹19095.3 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | T0318 | Tranilast ≥98% (HPLC), powder | 50MG | ₹64029.88 | 2022-06-14 | Buy |
Properties
Melting point :166.2-168.2 °C (lit.)
Boiling point :465.23°C (rough estimate)
Density :1.3185 (rough estimate)
refractive index :1.5100 (estimate)
storage temp. :2-8°C
solubility :DMSO: 18 mg/mL
form :powder
pka :3.47±0.36(Predicted)
color :white to beige
Merck :14,9570
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
InChIKey :NZHGWWWHIYHZNX-CSKARUKUSA-N
CAS DataBase Reference :53902-12-8(CAS DataBase Reference)
Boiling point :465.23°C (rough estimate)
Density :1.3185 (rough estimate)
refractive index :1.5100 (estimate)
storage temp. :2-8°C
solubility :DMSO: 18 mg/mL
form :powder
pka :3.47±0.36(Predicted)
color :white to beige
Merck :14,9570
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
InChIKey :NZHGWWWHIYHZNX-CSKARUKUSA-N
CAS DataBase Reference :53902-12-8(CAS DataBase Reference)
Safety Information
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| Signal word: | Warning | ||||||||||||||
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Description
Tranilast is a compound that exhibits anti-inflammatory and immunomodulatory effects by inhibiting lipid mediator and cytokine release from inflammatory cells and interfering with PDGF- and TGF-β1-induced proliferation and migration of vascular medial smooth muscle cells. Tranilast suppresses production of prostaglandin D2 (IC50 = 0.1 mM), prostaglandin E2 (IC50 = ~1-20 μM), thromboxane B2 (IC50 = ~10-50 μM), TGF-β1 (IC50 = ~100-200 μM), and interleukin-8 (IC50 = ~100 μM) in in vitro models as well as attenuates of the proinflammatory activity of human monocytes. While originally marketed as an antiallergenic drug, the efficacy of tranilast in preventing restenosis after percutaneous coronary intervention has been tested in a large-scale clinical trial. Additionally, tranilast inhibits VEGF-induced angiogenetic activities (i.e., proliferation, migration and tube formation of vascular endothelial cells) with IC50 values of 22, 18 and 193 μM, which may prove therapeutic for various retinal diseases.Related product price
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