Zaragozic acid A
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- Product name: Zaragozic acid A
- CAS: 142561-96-4
- MF: C35H46O14
- MW: 690.73
- EINECS:
- MDL Number:MFCD00868072
- Synonyms:Squalestatin 1;Aids111671;Aids-111671;Gr 105155x;L-Erythro-L-glycero-D-altro-7-trideculo-7,4-furanosonic acid, 2,7-anhydro-3,4-di-C-carboxy-8,9,10,12,13-pentadeoxy-10-methylene-12-(phenylmethyl)-, 11-acetate 5-[(2E,4S,6S)-4,6-dimethyl-2-octenoate], (7S)-;Squalestatin A, Squalestatin S1, L 694599;ZARAGOZIC ACID A;DFKDOZMCHOGOBR-NCSQYGPNSA-N
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Properties
alpha :D22 +18.3° (c = 0.60 in CHCl3); D25 +37° (c = 1.29 in methanol)
Boiling point :850.1±65.0 °C(Predicted)
Density :1.35±0.1 g/cm3(Predicted)
storage temp. :−20°C
solubility :Soluble in DMSO
form :solid
pka :1.47±0.70(Predicted)
color :white to light tan
CAS DataBase Reference :142561-96-4
Boiling point :850.1±65.0 °C(Predicted)
Density :1.35±0.1 g/cm3(Predicted)
storage temp. :−20°C
solubility :Soluble in DMSO
form :solid
pka :1.47±0.70(Predicted)
color :white to light tan
CAS DataBase Reference :142561-96-4
Safety Information
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Description
Squalene synthase catalyzes the first committed step in cholesterol synthesis, mediating the reductive dimerization of farnesyl pyrophosphate to produce squalene. Zaragozic acid A is a fungal metabolite that acts as a reversible competitive inhibitor of squalene synthase (Ki = 78 pM in vitro). It dose-dependently reduces cholesterol synthesis in HepG2 cells (IC50 = 6 μM) and inhibits hepatic cholesterol synthesis in mice (ED50 = 0.2 mg/kg). Zaragozic acid A also inhibits farnesyl-protein transferase and geranylgeranyl-protein transferase type I (IC50s = 216 and 50 nM, respectively).Related product price
- SQUALESTATIN
₹62211.28 - 3237-44-3
₹8930.63