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ChemicalBook > Product Catalogue >Biochemical Engineering >Inhibitors >PI3K / Akt / mTOR >GSK-3 inhibitors >Bikinin

Bikinin

Bikinin Structure
  • ₹8032.15 - ₹32604.9
  • Product name: Bikinin
  • CAS: 188011-69-0
  • MF: C9H9BrN2O3
  • MW: 273.08
  • EINECS:
  • MDL Number:MFCD00116442
  • Synonyms:Butanoic acid, 4-[(5-bromo-2-pyridinyl)amino]-4-oxo-;Bikinin;4-((5-Bromo-2-pyridinyl)amino)-4-oxobutanoic acid;4-[(5-Bromo-2-pyridinyl)amino]-4-oxo-butanoic acid;Abrasin;Bikinin(Abrasin);CS-1658;Bikinin, >98%
3 prices
Selected condition:

Brand

  • TCI Chemicals (India)
  • Sigma-Aldrich(India)

Package

  • 5MG
  • 25MG
  • ManufacturerTCI Chemicals (India)
  • Product numberB4826
  • Product descriptionBikinin
  • Packaging25MG
  • Price₹9200
  • Updated2022-05-26
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberSML0094
  • Product descriptionBikinin ≥98% (HPLC)
  • Packaging5MG
  • Price₹8032.15
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberSML0094
  • Product descriptionBikinin ≥98% (HPLC)
  • Packaging25MG
  • Price₹32604.9
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
TCI Chemicals (India) B4826 Bikinin 25MG ₹9200 2022-05-26 Buy
Sigma-Aldrich(India) SML0094 Bikinin ≥98% (HPLC) 5MG ₹8032.15 2022-06-14 Buy
Sigma-Aldrich(India) SML0094 Bikinin ≥98% (HPLC) 25MG ₹32604.9 2022-06-14 Buy

Properties

Melting point :144°C(lit.)
Boiling point :521.6±45.0 °C(Predicted)
Density :1.711
storage temp. :2-8°C
solubility :DMSO: ≥5mg/mL
pka :4.59±0.10(Predicted)
form :White solid
color :white to tan
InChIKey :XFYYQDHEDOXWGA-UHFFFAOYSA-N
CAS DataBase Reference :188011-69-0

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
Precautionary statements:
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

The Arabidopsis shaggy-related kinases (ASKs) are plant kinases that are structurally similar to a Drosophila kinase, shaggy, which has key roles in development. ASKs are also similar to glycogen synthase kinase 3 isoforms, which are found in plants as well as animals. Bikinin is an inhibitor of several ASK isoforms when given at a concentration of 10 μM. After bikinin treatment, residual kinase activity was less than 10% for ASKα, γ, ε, ζ, η, ι, and 20% for ASKθ, while isoforms β and δ were not affected. Bikinin has little or no direct effect on a wide range of other kinases. By inhibiting ASKs, bikinin activates signaling induced by the brassinosteroid, brassinolide. Bikinin blocks the phosphorylation of SnRK2.3 by ASKη (also known as BIN2), upregulating signaling through abscisic acid . Bikinin has been used to study the role of ASK-modulated brassinosteroid signaling in wheat and in viral infection of plants.

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