CASPASE INHIBITOR3
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- ₹99611.65
- Product name: CASPASE INHIBITOR3
- CAS: 187389-53-3
- MF: C11H18FNO5
- MW: 263.26
- EINECS:
- MDL Number:MFCD07370667
- Synonyms:CASPASE INHIBITOR3;(3S)-3-[[(1,1-Dimethylethoxy)carbonyl]amino]-5-fluoro-4-oxo-pentanoic acid methyl ester;N-Boc-L-aspartic acid 4-methyl ester fluoromethyl ketone;(S)-methyl 3-((tert-butoxycarbonyl)amino)-5-fluoro-4-oxopentanoate;N-BOC-D-FMK;Boc-D-FMK - Boc-Asp(OMe)-fluoromethyl ketone | BAF;Pentanoic acid, 3-[[(1,1-dimethylethoxy)carbonyl]amino]-5-fluoro-4-oxo-, methyl ester, (3S)-;Boc-D-FMK/Boc-Asp(OMe)-fluoromethyl ketone
1 prices
Selected condition：
Brand
- Sigma-Aldrich(India)
Package
- 3MG
- ManufacturerSigma-Aldrich(India)
- Product numberB2682
- Product descriptionBoc-Asp(OMe)-fluoromethyl ketone ≥90% (TLC), solid
- Packaging3MG
- Price₹99611.65
- Updated2022-06-14
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | B2682 | Boc-Asp(OMe)-fluoromethyl ketone ≥90% (TLC), solid | 3MG | ₹99611.65 | 2022-06-14 | Buy |
Properties
Boiling point :383.5±37.0 °C(Predicted)
Density :1.150±0.06 g/cm3 (20 ºC 760 Torr)
storage temp. :-20°C
solubility :Soluble in dry DMSO or DMF at approximately 20mM. Store stock solutions at -20°C.
pka :10.12±0.46(Predicted)
form :Powder
color :Off-white
Density :1.150±0.06 g/cm3 (20 ºC 760 Torr)
storage temp. :-20°C
solubility :Soluble in dry DMSO or DMF at approximately 20mM. Store stock solutions at -20°C.
pka :10.12±0.46(Predicted)
form :Powder
color :Off-white
Safety Information
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Description
Boc-D-FMK is a cell-permeable, irreversible pan-caspase inhibitor. Also known as Boc-D(OMe)-FMK, this compound contains a methyl ester group, which facilitates uptake by cells and subsequently is removed by cytoplasmic esterases, leaving the functional inhibitor. Boc-D-FMK blocks apoptosis stimulated by TNF-α in neutrophils (IC50 = 39 μM), by bile duct ligation in hepatocytes, and by TNF-α in renal endothelial cells. The FMK pharmacophore is known to interact with non-caspase cysteine proteases, presumably explaining why Boc-D-FMK also inhibits cathepsins H and L.Related product price
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