CYCLOPAMINE
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- ₹20660 - ₹54999.99
- Product name: CYCLOPAMINE
- CAS: 4449-51-8
- MF: C27H41NO2
- MW: 411.62
- EINECS:
- MDL Number:MFCD09878269
- Synonyms:11-DEOXOJERVINE;CyclopaMine, froM VeratruM californiciM;CYCLOPAMINE;Spiro[9H-benzo[a]fluorene-9,2'(3'H)-furo[3,2-b]pyridin]-3-ol,1,2,3,3'a,4,4',5',6,6',6a,6b,7,7',7'a,8,11,11a,11b-octadecahydro-3',6',10,11b-tetraMethyl-,(2'R,3S,3'R,3'aS,6'S,6aS,6bS,7'aR,11aS,11bR)-;Cyclopamine 11-Deoxojervine (3b,23b)-17,23-Epoxy-11-deoxoveratraman-3-ol;Cyclopamine, >=98%;(3S,6AS,6bS,8aR,10S,12aS,13S,13aS,15aS,15bR)-10,13,14,15b-tetramethyl-1,2,3,4,6,6a,6b,7,7a,8a;11-DEOXYJERVINE
3 prices
Selected condition:
Brand
- Sigma-Aldrich(India)
- ALFA India
Package
- 1MG
- 5MG
- 25mg
- ManufacturerSigma-Aldrich(India)
- Product number239803
- Product descriptionCyclopamine, V. californicum - CAS 4449-51-8 - Calbiochem Cyclopamine, V. californicum, CAS 4449-51-8, is a cell-permeable steroidal alkaloid & cholesterol mimic that specifically antagonizes Sonic Hedgehog s
- Packaging1MG
- Price₹20660
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product number239803
- Product descriptionCyclopamine, V. californicum - CAS 4449-51-8 - Calbiochem Cyclopamine, V. californicum, CAS 4449-51-8, is a cell-permeable steroidal alkaloid & cholesterol mimic that specifically antagonizes Sonic Hedgehog s
- Packaging5MG
- Price₹54999.99
- Updated2022-06-14
- Buy
- ManufacturerALFA India
- Product numberALF-J61528-MB
- Product descriptionCyclopamine, 99%
- Packaging25mg
- Price₹37848
- Updated2022-05-26
- Buy
Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|
Sigma-Aldrich(India) | 239803 | Cyclopamine, V. californicum - CAS 4449-51-8 - Calbiochem Cyclopamine, V. californicum, CAS 4449-51-8, is a cell-permeable steroidal alkaloid & cholesterol mimic that specifically antagonizes Sonic Hedgehog s | 1MG | ₹20660 | 2022-06-14 | Buy |
Sigma-Aldrich(India) | 239803 | Cyclopamine, V. californicum - CAS 4449-51-8 - Calbiochem Cyclopamine, V. californicum, CAS 4449-51-8, is a cell-permeable steroidal alkaloid & cholesterol mimic that specifically antagonizes Sonic Hedgehog s | 5MG | ₹54999.99 | 2022-06-14 | Buy |
ALFA India | ALF-J61528-MB | Cyclopamine, 99% | 25mg | ₹37848 | 2022-05-26 | Buy |
Properties
Melting point :236-238°C
Boiling point :531.29°C (rough estimate)
Density :1.0274 (rough estimate)
refractive index :1.6400 (estimate)
storage temp. :Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility :DMSO: soluble
form :solid
pka :15.05±0.70(Predicted)
color :White
Stability :Store in Freezer at - 20°C
Boiling point :531.29°C (rough estimate)
Density :1.0274 (rough estimate)
refractive index :1.6400 (estimate)
storage temp. :Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility :DMSO: soluble
form :solid
pka :15.05±0.70(Predicted)
color :White
Stability :Store in Freezer at - 20°C
Safety Information
Symbol(GHS): |
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Signal word: | Danger | ||||||||||||||
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Description
Cyclopamine is a natural steroidal alkaloid that inhibits signaling through the hedgehog pathway at the level of the pathway activator Smoothened. By altering gene expression in this signaling sequence, cyclopamine induces defects in morphogenesis, first observed in chicks and sheep as cyclopia. As a readout of action, cyclopamine inhibits hedgehog-dependent expression of Pax7 with an IC50 value of 24 nM. Although teratogenic during development, cyclopamine has potential applications in the treatment of cancer.More related product prices
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