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ChemicalBook > Product Catalogue >Biochemical Engineering >Inhibitors >Stem Cells & Wnt >Hedgehog / Smoothened antagonist >CYCLOPAMINE

CYCLOPAMINE

CYCLOPAMINE Structure
  • ₹20660 - ₹54999.99
  • Product name: CYCLOPAMINE
  • CAS: 4449-51-8
  • MF: C27H41NO2
  • MW: 411.62
  • EINECS:
  • MDL Number:MFCD09878269
  • Synonyms:11-DEOXOJERVINE;CyclopaMine, froM VeratruM californiciM;CYCLOPAMINE;Spiro[9H-benzo[a]fluorene-9,2'(3'H)-furo[3,2-b]pyridin]-3-ol,1,2,3,3'a,4,4',5',6,6',6a,6b,7,7',7'a,8,11,11a,11b-octadecahydro-3',6',10,11b-tetraMethyl-,(2'R,3S,3'R,3'aS,6'S,6aS,6bS,7'aR,11aS,11bR)-;Cyclopamine 11-Deoxojervine (3b,23b)-17,23-Epoxy-11-deoxoveratraman-3-ol;Cyclopamine, >=98%;(3S,6AS,6bS,8aR,10S,12aS,13S,13aS,15aS,15bR)-10,13,14,15b-tetramethyl-1,2,3,4,6,6a,6b,7,7a,8a;11-DEOXYJERVINE
Price3 Properties Safety Information Description
3 prices
Selected condition：

Brand

  • Sigma-Aldrich(India)
  • ALFA India

Package

  • 1MG
  • 5MG
  • 25mg
  • ManufacturerSigma-Aldrich(India)
  • Product number239803
  • Product descriptionCyclopamine, V. californicum - CAS 4449-51-8 - Calbiochem Cyclopamine, V. californicum, CAS 4449-51-8, is a cell-permeable steroidal alkaloid & cholesterol mimic that specifically antagonizes Sonic Hedgehog s
  • Packaging1MG
  • Price₹20660
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product number239803
  • Product descriptionCyclopamine, V. californicum - CAS 4449-51-8 - Calbiochem Cyclopamine, V. californicum, CAS 4449-51-8, is a cell-permeable steroidal alkaloid & cholesterol mimic that specifically antagonizes Sonic Hedgehog s
  • Packaging5MG
  • Price₹54999.99
  • Updated2022-06-14
  • Buy
  • ManufacturerALFA India
  • Product numberALF-J61528-MB
  • Product descriptionCyclopamine, 99%
  • Packaging25mg
  • Price₹37848
  • Updated2022-05-26
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) 239803 Cyclopamine, V. californicum - CAS 4449-51-8 - Calbiochem Cyclopamine, V. californicum, CAS 4449-51-8, is a cell-permeable steroidal alkaloid & cholesterol mimic that specifically antagonizes Sonic Hedgehog s 1MG ₹20660 2022-06-14 Buy
Sigma-Aldrich(India) 239803 Cyclopamine, V. californicum - CAS 4449-51-8 - Calbiochem Cyclopamine, V. californicum, CAS 4449-51-8, is a cell-permeable steroidal alkaloid & cholesterol mimic that specifically antagonizes Sonic Hedgehog s 5MG ₹54999.99 2022-06-14 Buy
ALFA India ALF-J61528-MB Cyclopamine, 99% 25mg ₹37848 2022-05-26 Buy

Properties

Melting point :236-238°C
Boiling point :531.29°C (rough estimate)
Density :1.0274 (rough estimate)
refractive index :1.6400 (estimate)
storage temp. :Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility :DMSO: soluble
form :solid
pka :15.05±0.70(Predicted)
color :White
Stability :Store in Freezer at - 20°C

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H301 Toxic if swalloed Acute toxicity,oral Category 3 Danger GHS hazard pictograms P264, P270, P301+P310, P321, P330,P405, P501
Precautionary statements:
P202 Do not handle until all safety precautions have been read and understood.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P405 Store locked up.

Description

Cyclopamine is a natural steroidal alkaloid that inhibits signaling through the hedgehog pathway at the level of the pathway activator Smoothened. By altering gene expression in this signaling sequence, cyclopamine induces defects in morphogenesis, first observed in chicks and sheep as cyclopia. As a readout of action, cyclopamine inhibits hedgehog-dependent expression of Pax7 with an IC50 value of 24 nM. Although teratogenic during development, cyclopamine has potential applications in the treatment of cancer.

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Suppliers and manufacturers

Chongqing Zhihe Biopharmaceutical Co., Ltd.
CYCLOPAMINE
₹0.00 /1kg
CYCLOPAMINE CAS:4449-51-8
career henan chemical co
CYCLOPAMINE
₹2.00 /1kg
CYCLOPAMINE CAS:4449-51-8
CLEARSYNTH LABS LTD. A.J Chemicals Alfa Aesar
Chengdu Biopurify Phytochemicals Ltd.
Shaanxi Pioneer Biotech Co., Ltd .
BOC Sciences
Chongqing Chemdad Co., Ltd
CONIER CHEM AND PHARMA LIMITED