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ChemicalBook > Product Catalogue >Analytical Chemistry >Standard >Standard Substance >CYCLOSPORIN D

CYCLOSPORIN D

CYCLOSPORIN D Structure
  • ₹26240.9
  • Product name: CYCLOSPORIN D
  • CAS: 63775-96-2
  • MF: C63H113N11O12
  • MW: 1216.64
  • EINECS:806-434-4
  • MDL Number:MFCD11111526
  • Synonyms:CYCLOSPORIN D;(3R,4R)-3-Hydroxy-N-methyl-5-[(E)-1-propenyl]-cyclo(L-Leu-L-Val-Sar-N-methyl-L-Leu-L-Val-N-methyl-L-Leu-L-Ala-D-Ala-N-methyl-L-Leu-N-methyl-L-Leu-N-methyl-L-Val-);(3R,4R)-3-Hydroxy-N-methyl-5-[(E)-1-propenyl]cyclo(L-Leu-L-Val-Sar-N-methyl-L-Leu-L-Val-N-methyl-L-Leu-L-Ala-D-Ala-N-methyl-L-Leu-N-methyl-L-Leu-N-methyl-L-Val-);Cyclo[L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl-3-hydroxy-N,4-dimethyl-L-2-amino-6-octenoyl-L-valyl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucyl];Val2-cyclosporine;7-L-Valinecyclosporin A;Cyclosporin D, froM MicroMonospora;Cyclosporine IMpurity-D
Price1 Properties Safety Information Description
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Brand

  • Sigma-Aldrich(India)

Package

  • 1ML
  • ManufacturerSigma-Aldrich(India)
  • Product numberC-108
  • Product descriptionCyclosporin D solution 1.0?mg/mL in acetonitrile, ampule of 1?mL, certified reference material, Cerilliant?
  • Packaging1ML
  • Price₹26240.9
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) C-108 Cyclosporin D solution 1.0?mg/mL in acetonitrile, ampule of 1?mL, certified reference material, Cerilliant? 1ML ₹26240.9 2022-06-14 Buy

Properties

Melting point :148-1510C
alpha :D20 -245° (c = 0.52 in CHCl3); D20 -211° (c = 0.51 in methanol)
Boiling point :1294.7±65.0 °C(Predicted)
Density :1.015±0.06 g/cm3(Predicted)
Flash point :9 °C
storage temp. :-20°C Freezer
solubility :Chloroform (Sparingly), Ethyl Aceatate (Slightly), Methanol (Slightly)
form :Colorless to off-white crystalline solid.
pka :13.22±0.70(Predicted)
color :White to Off-White
InChIKey :YJDYDFNKCBANTM-QCWCSKBGSA-N

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H225 Highly Flammable liquid and vapour Flammable liquids Category 2 Danger GHS hazard pictograms P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
Precautionary statements:
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Cyclosporin D is a metabolite of cyclosporin A, an immunosuppressant drug that binds cyclophilin D, inhibiting the phosphatase activity of calcineurin in T cells. Cyclosporin D displays about 10% lower immunosuppressant activity than cyclosporin A. Cyclosporin D has been used as an internal standard for the quantification of cyclosporin A.

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