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ChemicalBook > Product Catalogue >Biochemical Engineering >Inhibitors >Immunosuppressants >Cyclosporin A

Cyclosporin A

Cyclosporin A Structure
  • ₹4400 - ₹48528.48
  • Product name: Cyclosporin A
  • CAS: 59865-13-3
  • MF: C62H111N11O12
  • MW: 1202.61
  • EINECS:611-907-1
  • MDL Number:MFCD00274558
  • Synonyms:ol27-400 ;s7481f1 ;sandimmun ;Cyclospori;1,4,7,10,13,16,19,22,25,28,31-Undecaazacyclotritriacontane, cyclic peptide deriv.;30-Ethyl-33-(1-hydroxy-2-methyl-hex-4-enyl)-1,4,7,10,12,15,19,25,28-nonamethyl-6,9,18,24-tetrakis(2-methylpropyl)-3,21-dipropan-2-yl-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone;Cipol N;Neoplanta
Price12 Properties Safety Information Description
12 prices
Selected condition：

Brand

  • TCI Chemicals (India)
  • Sigma-Aldrich(India)

Package

  • 5MG
  • 10MG
  • 25MG
  • 100MG
  • 500MG
  • 1ML
  • 1G
  • ManufacturerTCI Chemicals (India)
  • Product numberC2408
  • Product descriptionCyclosporin A
  • Packaging100MG
  • Price₹4400
  • Updated2022-05-26
  • Buy
  • ManufacturerTCI Chemicals (India)
  • Product numberC2408
  • Product descriptionCyclosporin A
  • Packaging1G
  • Price₹9400
  • Updated2022-05-26
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberSML1018
  • Product descriptionCyclosporin A, Ready Made Solution 1?mg/mL in DMSO
  • Packaging1ML
  • Price₹13020.7
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberPHR1092
  • Product descriptionCyclosporine Pharmaceutical Secondary Standard; Certified Reference Material
  • Packaging500MG
  • Price₹15144.18
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product number30024
  • Product descriptionCyclosporin A 97.0-101.5% (on dried basis)
  • Packaging25MG
  • Price₹18218.48
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberC3662
  • Product descriptionCyclosporin A from Tolypocladium inflatum, ≥95% (HPLC), solid
  • Packaging5MG
  • Price₹20567.5
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberC-093
  • Product descriptionCyclosporin A solution 1.0?mg/mL in acetonitrile, ampule of 1?mL, certified reference material, Cerilliant?
  • Packaging1ML
  • Price₹23487.8
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberC1832
  • Product descriptionCyclosporin A from Tolypocladium inflatum, BioReagent, for molecular biology, ≥95%
  • Packaging5MG
  • Price₹26954.25
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product number32425
  • Product descriptionCyclosporin A VETRANAL?, analytical standard
  • Packaging100MG
  • Price₹30591.45
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberC3662
  • Product descriptionCyclosporin A from Tolypocladium inflatum, ≥95% (HPLC), solid
  • Packaging10MG
  • Price₹34542.58
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product number30024
  • Product descriptionCyclosporin A 97.0-101.5% (on dried basis)
  • Packaging100MG
  • Price₹40030.85
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberC1832
  • Product descriptionCyclosporin A from Tolypocladium inflatum, BioReagent, for molecular biology, ≥95%
  • Packaging10MG
  • Price₹48528.48
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
TCI Chemicals (India) C2408 Cyclosporin A 100MG ₹4400 2022-05-26 Buy
TCI Chemicals (India) C2408 Cyclosporin A 1G ₹9400 2022-05-26 Buy
Sigma-Aldrich(India) SML1018 Cyclosporin A, Ready Made Solution 1?mg/mL in DMSO 1ML ₹13020.7 2022-06-14 Buy
Sigma-Aldrich(India) PHR1092 Cyclosporine Pharmaceutical Secondary Standard; Certified Reference Material 500MG ₹15144.18 2022-06-14 Buy
Sigma-Aldrich(India) 30024 Cyclosporin A 97.0-101.5% (on dried basis) 25MG ₹18218.48 2022-06-14 Buy
Sigma-Aldrich(India) C3662 Cyclosporin A from Tolypocladium inflatum, ≥95% (HPLC), solid 5MG ₹20567.5 2022-06-14 Buy
Sigma-Aldrich(India) C-093 Cyclosporin A solution 1.0?mg/mL in acetonitrile, ampule of 1?mL, certified reference material, Cerilliant? 1ML ₹23487.8 2022-06-14 Buy
Sigma-Aldrich(India) C1832 Cyclosporin A from Tolypocladium inflatum, BioReagent, for molecular biology, ≥95% 5MG ₹26954.25 2022-06-14 Buy
Sigma-Aldrich(India) 32425 Cyclosporin A VETRANAL?, analytical standard 100MG ₹30591.45 2022-06-14 Buy
Sigma-Aldrich(India) C3662 Cyclosporin A from Tolypocladium inflatum, ≥95% (HPLC), solid 10MG ₹34542.58 2022-06-14 Buy
Sigma-Aldrich(India) 30024 Cyclosporin A 97.0-101.5% (on dried basis) 100MG ₹40030.85 2022-06-14 Buy
Sigma-Aldrich(India) C1832 Cyclosporin A from Tolypocladium inflatum, BioReagent, for molecular biology, ≥95% 10MG ₹48528.48 2022-06-14 Buy

Properties

Melting point :148-151°C
Boiling point :838.63°C (rough estimate)
alpha :D20 -244° (c = 0.6 in chloroform); D20 -189° (c = 0.5 in methanol)
Density :0.9913 (rough estimate)
refractive index :1.6500 (estimate)
Flash point :87℃
storage temp. :-20°C
solubility :ethanol: 30 mg/mL
form :solid
pka :13.32±0.70(Predicted)
color :white
Water Solubility :Soluble in dimethyl sulfoxide and ethanol. Insoluble in water.
Merck :14,2752
BRN :3647785
Stability :Stable for 3 years as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
InChIKey :PMATZTZNYRCHOR-CGLBZJNRSA-N
CAS DataBase Reference :59865-13-3(CAS DataBase Reference)
IARC :1 (Vol. 50, 100A) 2012
EPA Substance Registry System :Cyclosporin A (59865-13-3)

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H350 May cause cancer Carcinogenicity Category 1A, 1B Danger GHS hazard pictograms
Precautionary statements:
P201 Obtain special instructions before use.
P202 Do not handle until all safety precautions have been read and understood.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P308+P313 IF exposed or concerned: Get medical advice/attention.

Description

Cyclosporin A is an immunosuppressant drug that binds cyclophilin D, inhibiting the phosphatase activity of calcineurin in T cells (IC50 = 5 nM). It blocks the transcription of genes involved in T cell activation by interfering with the calcineurin-driven nuclear import of the transcription factor NFAT. Because of its powerful immunosuppressant activity, cyclosporin A has long been used for the prevention of transplant rejection.

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Suppliers and manufacturers

Clickchem Research LLP Novas International HiMedia Laboratories Maas Pharma Chemicals Newedge Overseas Thykn (India) International Mulji Mehta Pharma Pharma Affiliates Cytochrome Life Sciences Pvt., Ltd. Atlanta Associates