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Cyclosporin H

Cyclosporin H Structure
  • ₹10954.9 - ₹44057.75
  • Product name: Cyclosporin H
  • CAS: 83602-39-5
  • MF: C62H111N11O12
  • MW: 1202.61
  • EINECS:
  • MDL Number:MFCD04039488
  • Synonyms:CYCLOSPORIN H;Cyclo[L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-D-valyl-3-hydroxy-N,4-dimethyl-L-2-amino-6-octenoyl-L-2-aminobutanoyl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucyl];5-(N-Methyl-D-valine)cyclosporin A;Cyclo[L-alanyl-D-alanyl-N-Methyl-L- leucyl-N-Methyl-L-leucyl-N-Methyl-D-valyl-(3R,4R,6E)-6,7-didehydro-3-hydroxy-N,4-diMethyl-L-2-aMinooctanoyl-L-2-aMinobutanoyl-N-Methylglycyl-N-Methyl-L-leucyl-L-valyl-N-Methyl-L-leucyl];Sandoz 37-839;Cyclosporin H, >=95%;Cyclosporine IMpurity-H;5-(N-Methyl-D-valine)cyclosporine A
Price2 Properties Safety Information Description
2 prices
Selected condition：

Brand

  • Sigma-Aldrich(India)

Package

  • 1MG
  • 5MG
  • ManufacturerSigma-Aldrich(India)
  • Product numberSML1575
  • Product descriptionCyclosporin H ≥97% (HPLC)
  • Packaging1MG
  • Price₹10954.9
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberSML1575
  • Product descriptionCyclosporin H ≥97% (HPLC)
  • Packaging5MG
  • Price₹44057.75
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) SML1575 Cyclosporin H ≥97% (HPLC) 1MG ₹10954.9 2022-06-14 Buy
Sigma-Aldrich(India) SML1575 Cyclosporin H ≥97% (HPLC) 5MG ₹44057.75 2022-06-14 Buy

Properties

Melting point :148-151°C
Boiling point :1293.8±65.0 °C(Predicted)
Density :1.016±0.06 g/cm3(Predicted)
storage temp. :-20°C
solubility :Chloroform (Slightly), Methanol (Slightly, Heated, Sonicated)
pka :13.32±0.70(Predicted)
form :powder
color :white to beige
optical activity :[α]/D -100 to -115°, c = 0.5 in methanol

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H350 May cause cancer Carcinogenicity Category 1A, 1B Danger GHS hazard pictograms
H360 May damage fertility or the unborn child Reproductive toxicity Category 1A, 1B Danger GHS hazard pictograms
Precautionary statements:
P202 Do not handle until all safety precautions have been read and understood.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P308+P313 IF exposed or concerned: Get medical advice/attention.

Description

Cyclosporin H is a natural cyclic undecapeptide that selectively antagonizes the formyl peptide receptor at concentrations ranging from 0.1 to 10 μM. Unlike cyclosporin A , cyclosporin H does not bind cyclophilin to evoke an immunosuppressant response. Cyclosporin H has been reported to inhibit phorbol ester-mediated effects in mouse skin and block calcium/calmodulin-dependent EF-2 phosphorylation in vitro.

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Suppliers and manufacturers

CLEARSYNTH LABS LTD. SynZeal Research Pvt Ltd Pharmaffiliates Analytics and Synthetics P. Ltd Pharma Affiliates
Shenzhen Excellent Biomedical Technology Co.,Ltd.
LEAP CHEM CO., LTD.
Hangzhou FandaChem Co.,Ltd.
Shaanxi Pioneer Biotech Co., Ltd .
BOC Sciences
SIMAGCHEM CORP