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ChemicalBook > Product Catalogue >API >Nervous system drugs >Antidepressants, Antimanics drugs >DESIPRAMINE HYDROCHLORIDE

DESIPRAMINE HYDROCHLORIDE

DESIPRAMINE HYDROCHLORIDE Structure
  • ₹2407.3 - ₹73296.08
  • Product name: DESIPRAMINE HYDROCHLORIDE
  • CAS: 58-28-6
  • MF: C18H23ClN2
  • MW: 302.84
  • EINECS:200-373-1
  • MDL Number:MFCD00058108
  • Synonyms:Desipramine solution hydrochloride;RMI-9384A;10-11-Dihydro-N-methyl-5H-dibenz(Z)[b,f]azepine-5-propanaminehydrochloride;Desipramine Hydrochloride (125 mg);Desipramine Hydrochloride (125 mg)I0E2831.000mg/mg(dr);10,11-Dihydro-5-[3-(methylamino)propyl]-5H-dibenz[b,f]azepine monohydrochloride;5-[3-(Methylamino)propyl]-5H-dibenz[b,f]azepine hydrochloride;10,11-dihydro-5-(3-(methylamino)propyl)-5h-dibenz(b,f)azepinehydrochloride
5 prices
Selected condition:

Brand

  • Sigma-Aldrich(India)

Package

  • 400MG
  • 1ML
  • 1G
  • 5G
  • 25G
  • ManufacturerSigma-Aldrich(India)
  • Product numberD-906
  • Product descriptionDesipramine hydrochloride solution 1.0?mg/mL in methanol (as free base), ampule of 1?mL, certified reference material, Cerilliant?
  • Packaging1ML
  • Price₹2407.3
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberD3900
  • Product descriptionDesipramine hydrochloride ≥98% (TLC), powder
  • Packaging1G
  • Price₹5174.35
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberPHR1723
  • Product descriptionDesipramine Hydrochloride Pharmaceutical Secondary Standard; Certified Reference Material
  • Packaging400MG
  • Price₹13769.4
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberD3900
  • Product descriptionDesipramine hydrochloride ≥98% (TLC), powder
  • Packaging5G
  • Price₹18857.15
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberD3900
  • Product descriptionDesipramine hydrochloride ≥98% (TLC), powder
  • Packaging25G
  • Price₹73296.08
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) D-906 Desipramine hydrochloride solution 1.0?mg/mL in methanol (as free base), ampule of 1?mL, certified reference material, Cerilliant? 1ML ₹2407.3 2022-06-14 Buy
Sigma-Aldrich(India) D3900 Desipramine hydrochloride ≥98% (TLC), powder 1G ₹5174.35 2022-06-14 Buy
Sigma-Aldrich(India) PHR1723 Desipramine Hydrochloride Pharmaceutical Secondary Standard; Certified Reference Material 400MG ₹13769.4 2022-06-14 Buy
Sigma-Aldrich(India) D3900 Desipramine hydrochloride ≥98% (TLC), powder 5G ₹18857.15 2022-06-14 Buy
Sigma-Aldrich(India) D3900 Desipramine hydrochloride ≥98% (TLC), powder 25G ₹73296.08 2022-06-14 Buy

Properties

Melting point :214-2160C
Flash point :11 °C
storage temp. :2-8°C
solubility :H2O: 50 mg/mL
form :powder
color :white to off-white
Water Solubility :Soluble to 100 mM in water

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H317 May cause an allergic skin reaction Sensitisation, Skin Category 1 Warning GHS hazard pictograms P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled Sensitisation, respiratory Category 1 Danger GHS hazard pictograms P261, P285, P304+P341, P342+P311,P501
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Desipramine HCl is a selective inhibitor of noradrenaline the transporters norepinephrine transporter (SLC6A2 or NET; Ki = 4 nM), serotonin transporter (ST or SERT; Ki = 61 nM), and dopamine transporter (DAT; Ki = 78,720 nM). This compound is a potent inhibitor of the norepinephrine transporter, and also blocks serotonin re-uptake. This compound has also been shown to reverse the pro-apoptotic effect of chronic unpredictable mild stress in the rat cerebral cortex, although it induces apoptosis in several cancer cell lines. It has also been shown to display antiinflammatory activity in a rat colitis model.

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