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ChemicalBook > Product Catalogue >Biochemical Engineering >Inhibitors >Immunosuppressants >Ifosfamide

Ifosfamide

Ifosfamide Structure
  • ₹17493.2 - ₹54384.8
  • Product name: Ifosfamide
  • CAS: 3778-73-2
  • MF: C7H15Cl2N2O2P
  • MW: 261.09
  • EINECS:223-237-3
  • MDL Number:MFCD00057374
  • Synonyms:holoxan ;holoxan1000 ;iphosphamide ;isoendoxan ;isofosfamide ;mjf9325 ;n-(2-chloraethyl)-n’-(2-chloraethyl)-n’,o-propylen-phosphorsaureester-diamid ;n-(2-chloroethyl)-n’-(2-chloroethyl)-n’,o-propylenephosphoricaciddiamide
3 prices
Selected condition:

Brand

  • Sigma-Aldrich(India)

Package

  • 1G
  • 5G
  • ManufacturerSigma-Aldrich(India)
  • Product numberI4909
  • Product descriptionIfosfamide ≥98%
  • Packaging1G
  • Price₹17493.2
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberPHR3187
  • Product descriptionIfosfamide pharmaceutical secondary standard, certified reference material
  • Packaging1G
  • Price₹19625.73
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberI4909
  • Product descriptionIfosfamide ≥98%
  • Packaging5G
  • Price₹54384.8
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) I4909 Ifosfamide ≥98% 1G ₹17493.2 2022-06-14 Buy
Sigma-Aldrich(India) PHR3187 Ifosfamide pharmaceutical secondary standard, certified reference material 1G ₹19625.73 2022-06-14 Buy
Sigma-Aldrich(India) I4909 Ifosfamide ≥98% 5G ₹54384.8 2022-06-14 Buy

Properties

Melting point :48°C
Boiling point :336.1±52.0 °C(Predicted)
Density :1.33±0.1 g/cm3(Predicted)
storage temp. :Inert atmosphere,2-8°C
solubility :DMF:50.0(Max Conc. mg/mL);191.51(Max Conc. mM)
DMSO:44.0(Max Conc. mg/mL);168.53(Max Conc. mM)
Ethanol:51.0(Max Conc. mg/mL);195.34(Max Conc. mM)
PBS (pH 7.2):10.0(Max Conc. mg/mL);38.3(Max Conc. mM)
Water:52.0(Max Conc. mg/mL);199.17(Max Conc. mM) pka :1.44±0.20(Predicted)
form :Solid
color :White to off-white
CAS DataBase Reference :3778-73-2(CAS DataBase Reference)
IARC :3 (Vol. 26, Sup 7) 1987
EPA Substance Registry System :Isophosphamide (3778-73-2)

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H301 Toxic if swalloed Acute toxicity,oral Category 3 Danger GHS hazard pictograms P264, P270, P301+P310, P321, P330,P405, P501
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H340 May cause genetic defects Germ cell mutagenicity Category 1A, 1B Danger GHS hazard pictograms
H350 May cause cancer Carcinogenicity Category 1A, 1B Danger GHS hazard pictograms
H360 May damage fertility or the unborn child Reproductive toxicity Category 1A, 1B Danger GHS hazard pictograms
Precautionary statements:
P201 Obtain special instructions before use.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Ifosfamide is a nitrogen mustard alkylating agent used as a chemotherapeutic agent against advanced transitional cell carcinoma. It is a structural derivative of cyclophosphamide that was developed for improved solubility and antitumor activity. Like cyclophosphamide, ifosfamide serves as a prodrug that is either metabolized to its active DNA alkylating form, isophosphoramide mustard, or catabolized through a dechloroethylation pathway to the neurotoxic and nephrotoxic chloroacetaldehyde.

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