ISRIB (trans-isoMer)
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- ₹11506.98 - ₹46374.3
- Product name: ISRIB (trans-isoMer)
- CAS: 1597403-47-8
- MF: C22H24Cl2N2O4
- MW: 451.34
- EINECS:
- MDL Number:MFCD27952932
- Synonyms:ISRIB (trans-isoMer);trans-N,N'-(cyclohexane-1,4-diyl)bis(2-(4-chlorophenoxy)acetamide);N,N'-((1r,4r)-cyclohexane-1,4-diyl)bis(2-(4-chlorophenoxy)acetamide) ISRIB(trans-isomer);Trans-ISRIB;Acetamide, N,N'-trans-1,4-cyclohexanediylbis[2-(4-chlorophenoxy)-;N,N'-trans-1,4-cyclohexanediylbis[2-(4-chlorophenoxy)acetamide];CS-1768;ISRIB - trans-ISRIB
2 prices
Selected condition：
Brand
- Sigma-Aldrich(India)
Package
- 5MG
- 25MG
- ManufacturerSigma-Aldrich(India)
- Product numberSML0843
- Product descriptionISRIB ≥98% (HPLC)
- Packaging5MG
- Price₹11506.98
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberSML0843
- Product descriptionISRIB ≥98% (HPLC)
- Packaging25MG
- Price₹46374.3
- Updated2022-06-14
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | SML0843 | ISRIB ≥98% (HPLC) | 5MG | ₹11506.98 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | SML0843 | ISRIB ≥98% (HPLC) | 25MG | ₹46374.3 | 2022-06-14 | Buy |
Properties
Boiling point :719.0±60.0 °C(Predicted)
Density :1.33±0.1 g/cm3(Predicted)
storage temp. :2-8°C
solubility :insoluble in EtOH; insoluble in H2O; insoluble in EtOH; ≥8.96 mg/mL in DMSO with gentle warming
form :solid
pka :13.63±0.40(Predicted)
color :White to off-white
Density :1.33±0.1 g/cm3(Predicted)
storage temp. :2-8°C
solubility :insoluble in EtOH; insoluble in H2O; insoluble in EtOH; ≥8.96 mg/mL in DMSO with gentle warming
form :solid
pka :13.63±0.40(Predicted)
color :White to off-white
Safety Information
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Description
Phosphorylation of eIF2α by several kinases in response to cellular stress, including accumulation of unfolded proteins in the ER, results in a decrease in overall protein synthesis but upregulation of a small number of key regulatory proteins. trans-ISRIB (Integrated Stress Response Inhibitor) is a symmetric bis-glycolamide that inhibits the eIF2α phosphorylation-mediated unfolded protein response following induction of ER stress (IC50 = 5 nM in a cell-reporter assay). Although the mechanism of action is not established, it does not directly inhibit phosphorylation of eIF2α by upstream kinases. trans-ISRIB is able to pass through the blood-brain barrier and significantly enhances learning and memory in mice and rats.Related product price
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