Itraconazole
- ₹10900 - ₹23111.38
- Product name: Itraconazole
- CAS: 84625-61-6
- MF: C35H38Cl2N8O4
- MW: 705.63
- EINECS:617-596-9
- MDL Number:MFCD00870168
- Synonyms:ITRACONAZOLE-D3;ITRACONAZOLE;SPORANOX;R51211;ORICONAZOLE;TRIASPORIN;-1-ylmethyl)-1,3-dioxolan-4-yl)methoxy)phenyl)-1-piperazinyl)phenyl)-2,4-dihyd ;3h-1,2,4-triazol-3-one,4-(4-(4-(4-((2-(2,4-dichlorophenyl)-2-(1h-1,2,4-triazol
6 prices
Selected condition:
Brand
- TCI Chemicals (India)
- Sigma-Aldrich(India)
Package
- 100MG
- 200MG
- 250MG
- 1ML
- 5G
- 25G
- ManufacturerTCI Chemicals (India)
- Product numberI0732
- Product descriptionItraconazole
- Packaging5G
- Price₹10900
- Updated2022-05-26
- Buy
- ManufacturerTCI Chemicals (India)
- Product numberI0732
- Product descriptionItraconazole
- Packaging25G
- Price₹20800
- Updated2022-05-26
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberI-015
- Product descriptionItraconazole solution 2.0?mg/mL (Methanol with 1% 1M HCl), ampule of 1?mL, certified reference material, Cerilliant?
- Packaging1ML
- Price₹11251.8
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product number419825
- Product descriptionHh Signaling Antagonist X, Itraconazole - CAS 84625-61-6 - Calbiochem The Hh Signaling Antagonist X, Itraconazole, also referenced under CAS 84625-61-6, controls the biological activity of Hh pathway. This small molecule
- Packaging250MG
- Price₹14100
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberPHR1834
- Product descriptionItraconazole Pharmaceutical Secondary Standard; Certified Reference Material
- Packaging200MG
- Price₹18037.5
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberI6657
- Product descriptionItraconazole ≥98% (TLC)
- Packaging100MG
- Price₹23111.38
- Updated2022-06-14
- Buy
Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|
TCI Chemicals (India) | I0732 | Itraconazole | 5G | ₹10900 | 2022-05-26 | Buy |
TCI Chemicals (India) | I0732 | Itraconazole | 25G | ₹20800 | 2022-05-26 | Buy |
Sigma-Aldrich(India) | I-015 | Itraconazole solution 2.0?mg/mL (Methanol with 1% 1M HCl), ampule of 1?mL, certified reference material, Cerilliant? | 1ML | ₹11251.8 | 2022-06-14 | Buy |
Sigma-Aldrich(India) | 419825 | Hh Signaling Antagonist X, Itraconazole - CAS 84625-61-6 - Calbiochem The Hh Signaling Antagonist X, Itraconazole, also referenced under CAS 84625-61-6, controls the biological activity of Hh pathway. This small molecule | 250MG | ₹14100 | 2022-06-14 | Buy |
Sigma-Aldrich(India) | PHR1834 | Itraconazole Pharmaceutical Secondary Standard; Certified Reference Material | 200MG | ₹18037.5 | 2022-06-14 | Buy |
Sigma-Aldrich(India) | I6657 | Itraconazole ≥98% (TLC) | 100MG | ₹23111.38 | 2022-06-14 | Buy |
Properties
Melting point :166°C
alpha :-0.1~+0.1°(D/20℃)(c=10,CH2Cl2)
Boiling point :850.0±75.0 °C(Predicted)
Density :1.27 g/cm3
Flash point :>110°(230°F)
storage temp. :2-8°C
solubility :chloroform: 50 mg/mL, clear, colorless
pka :3.7(at 25℃)
form :White powder
color :white
Water Solubility :Insoluble in water. Solube in chloroform at 50 mg/ml. Slightly soluble in ethanol or methanol
Merck :14,5245
Stability :Stable. Incompatible with strong oxidizing agents.
InChIKey :VHVPQPYKVGDNFY-UHFFFAOYSA-N
CAS DataBase Reference :84625-61-6(CAS DataBase Reference)
alpha :-0.1~+0.1°(D/20℃)(c=10,CH2Cl2)
Boiling point :850.0±75.0 °C(Predicted)
Density :1.27 g/cm3
Flash point :>110°(230°F)
storage temp. :2-8°C
solubility :chloroform: 50 mg/mL, clear, colorless
pka :3.7(at 25℃)
form :White powder
color :white
Water Solubility :Insoluble in water. Solube in chloroform at 50 mg/ml. Slightly soluble in ethanol or methanol
Merck :14,5245
Stability :Stable. Incompatible with strong oxidizing agents.
InChIKey :VHVPQPYKVGDNFY-UHFFFAOYSA-N
CAS DataBase Reference :84625-61-6(CAS DataBase Reference)
Safety Information
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Description
The Hedgehog signaling pathway is critical for embryonic growth and patterning as well as stem cell and progenitor cell tissue homeostasis. Inappropriate Hedgehog activity has been linked to tumor formation. Itraconazole is a systemic antifungal agent with a distinct antagonist effect on Hedgehog signaling. With an IC50 value of 0.8 μM in vitro, itraconazole behaves as an inverse agonist downstream of Patched (Ptch), yet upstream of Smoothened (Smo) to disrupt Hedgehog signaling. Treatment with 100 mg/kg itraconazole twice per day has been shown to suppress the growth of medulloblastomas from a Ptch+/-p53-/- mouse allograft model in as few as five days.More related product prices
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