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JASPLAKINOLIDE

JASPLAKINOLIDE Structure
  • ₹78708.58
  • Product name: JASPLAKINOLIDE
  • CAS: 102396-24-7
  • MF: C36H45BrN4O6
  • MW: 709.67
  • EINECS:
  • MDL Number:MFCD00873735
  • Synonyms:JASPLAKINOLIDE;JASPLAKINOLIDE, JASPIS JOHNSTONI;(3S,6R,9R,13S,15R,16E,19S)-3,5,13,15,17,19-Hexamethyl-6-[(2-bromo-1H-indole-3-yl)methyl]-9-(4-hydroxyphenyl)-12-oxa-2,5,8-triazacyclononadeca-16-ene-1,4,7,11-tetraone;[3S,6R,9R,13S,15R,19S,16E,(+)]-6-[(2-Bromo-1H-indol-3-yl)methyl]-9-(4-hydroxyphenyl)-3,5,13,15,17,19-hexamethyl-2,5,8-triaza-12-oxacyclononadecan-16-ene-1,4,7,11-tetrone;NSC 613009;Jasplakinolide, Jaspis johnstoni - CAS 102396-24-7 - Calbiochem;Cyclo[(3R)-3-(4-hydroxyphenyl)-β-alanyl-(2S,4E,6R,8S)-8-hydroxy-2,4,6-trimethyl-4-nonenoyl-L-alanyl-2-bromo-N-methyl-D-tryptophyl];GQWYWHOHRVVHAP-DHKPLNAMSA-N
Price1 Properties Safety Information Description
1 prices
Selected condition：

Brand

  • Sigma-Aldrich(India)

Package

  • 100μG
  • ManufacturerSigma-Aldrich(India)
  • Product numberJ4580
  • Product descriptionJasplakinolide ≥97% (HPLC)
  • Packaging100μG
  • Price₹78708.58
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) J4580 Jasplakinolide ≥97% (HPLC) 100μG ₹78708.58 2022-06-14 Buy

Properties

Melting point :110℃ (decomposition)
storage temp. :-20°C
solubility :DMSO: >2mg/mL
form :Off-white solid
color :off white to beige

Safety Information

Symbol(GHS):
Signal word:
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H413 May cause long lasting harmful effects to aquatic life Hazardous to the aquatic environment, long-term hazard Category 4
Precautionary statements:
P273 Avoid release to the environment.
P501 Dispose of contents/container to..…

Description

Jasplakinolide is a natural macrocyclic peptide first isolated from a marine sponge. It potently inhibits the proliferation of PC3 prostate carcinoma cells (IC50 = 35 nM) by binding F-actin (KD = 15 nM). This binding of jasplakinolide to actin, which is competitive with phalloidin, stabilizes actin filaments in vitro but disrupts actin filaments and induces irregular polymerization of monomeric actin in vivo. This compound is used to investigate the role of actin in diverse cellular roles, such as motility, transport, and development.

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