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JASPLAKINOLIDE

JASPLAKINOLIDE Structure
CAS No.
102396-24-7
Chemical Name:
JASPLAKINOLIDE
Synonyms
NSC 613009;JASPLAKINOLIDE;GQWYWHOHRVVHAP-DHKPLNAMSA-N;JASPLAKINOLIDE, JASPIS JOHNSTONI;Jasplakinolide, Jaspis johnstoni - CAS 102396-24-7 - Calbiochem;Cyclo[(3R)-3-(4-hydroxyphenyl)-β-alanyl-(2S,4E,6R,8S)-8-hydroxy-2,4,6-trimethyl-4-nonenoyl-L-alanyl-2-bromo-N-methyl-D-tryptophyl];(3S,6R,9R,13S,15R,16E,19S)-3,5,13,15,17,19-Hexamethyl-6-[(2-bromo-1H-indole-3-yl)methyl]-9-(4-hydroxyphenyl)-12-oxa-2,5,8-triazacyclononadeca-16-ene-1,4,7,11-tetraone;[3S,6R,9R,13S,15R,19S,16E,(+)]-6-[(2-Bromo-1H-indol-3-yl)methyl]-9-(4-hydroxyphenyl)-3,5,13,15,17,19-hexamethyl-2,5,8-triaza-12-oxacyclononadecan-16-ene-1,4,7,11-tetrone
CBNumber:
CB0703307
Molecular Formula:
C36H45BrN4O6
Molecular Weight:
709.67
MOL File:
102396-24-7.mol
MSDS File:
SDS
Modify Date:
2023/6/30 15:45:59
Request For Quotation

JASPLAKINOLIDE Properties

Melting point 110℃ (decomposition)
storage temp. -20°C
solubility DMSO: >2mg/mL
form Off-white solid
color off white to beige

SAFETY

Risk and Safety Statements

Hazard statements  H413
Precautionary statements  P273-P501
RIDADR  3172
WGK Germany  3
RTECS  GX7000000
HazardClass  6.1(b)
PackingGroup  III

JASPLAKINOLIDE price More Price(1)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) J4580 Jasplakinolide ≥97% (HPLC) 102396-24-7 100μG ₹78708.58 2022-06-14 Buy
Product number Packaging Price Buy
J4580 100μG ₹78708.58 Buy

JASPLAKINOLIDE Chemical Properties,Uses,Production

Description

Jasplakinolide is a natural macrocyclic peptide first isolated from a marine sponge. It potently inhibits the proliferation of PC3 prostate carcinoma cells (IC50 = 35 nM) by binding F-actin (KD = 15 nM). This binding of jasplakinolide to actin, which is competitive with phalloidin, stabilizes actin filaments in vitro but disrupts actin filaments and induces irregular polymerization of monomeric actin in vivo. This compound is used to investigate the role of actin in diverse cellular roles, such as motility, transport, and development.

Uses

Jasplakinolide is a potent inhibitor of prostrate and breast carcinoma cell proliferation. Also acts as an actin stabilizing agent, affecting chromosome movement in studies.

Definition

ChEBI: A cyclodepsipeptide isolated from Jaspis splendens and has been shown to exhibit antineoplastic activity.

JASPLAKINOLIDE Preparation Products And Raw materials

Raw materials

Preparation Products

JASPLAKINOLIDE Suppliers

Global( 45)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6351 58 Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 +1-00000000000 United States 19892 58 Inquiry
Alfa Chemistry United States 24072 58 Inquiry
Aladdin Scientific +1-+1(833)-552-7181 United States 57511 58 Inquiry
Wuhan Fortuna Chemical Co.,Ltd +8618007136271 China 5774 58 Inquiry
Shanghai Aladdin Bio-Chem Technology Co.,LTD 400-400-6206333 18521732826 China 25013 65 Inquiry
Nantong Hanfang Biotechnology Co. , Ltd. 18616537568 China 30968 58 Inquiry
TargetMol Chemicals Inc. 15002134094 China 28091 58 Inquiry
Chengdu Peter-like Biotechnology Co., Ltd. 028-81700200 18108052721 China 5178 58 Inquiry
MedBioPharmaceutical Technology Inc 021-69568360 18916172912 China 8141 58 Inquiry
Supplier Advantage
CLEARSYNTH LABS LTD. 58
TargetMol Chemicals Inc. 58
Alfa Chemistry 58
Aladdin Scientific 58
Wuhan Fortuna Chemical Co.,Ltd 58
Shanghai Aladdin Bio-Chem Technology Co.,LTD 65
Nantong Hanfang Biotechnology Co. , Ltd. 58
TargetMol Chemicals Inc. 58
Chengdu Peter-like Biotechnology Co., Ltd. 58
MedBioPharmaceutical Technology Inc 58

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JASPLAKINOLIDE JASPLAKINOLIDE, JASPIS JOHNSTONI (3S,6R,9R,13S,15R,16E,19S)-3,5,13,15,17,19-Hexamethyl-6-[(2-bromo-1H-indole-3-yl)methyl]-9-(4-hydroxyphenyl)-12-oxa-2,5,8-triazacyclononadeca-16-ene-1,4,7,11-tetraone [3S,6R,9R,13S,15R,19S,16E,(+)]-6-[(2-Bromo-1H-indol-3-yl)methyl]-9-(4-hydroxyphenyl)-3,5,13,15,17,19-hexamethyl-2,5,8-triaza-12-oxacyclononadecan-16-ene-1,4,7,11-tetrone NSC 613009 Jasplakinolide, Jaspis johnstoni - CAS 102396-24-7 - Calbiochem Cyclo[(3R)-3-(4-hydroxyphenyl)-β-alanyl-(2S,4E,6R,8S)-8-hydroxy-2,4,6-trimethyl-4-nonenoyl-L-alanyl-2-bromo-N-methyl-D-tryptophyl] GQWYWHOHRVVHAP-DHKPLNAMSA-N 102396-24-7 Amines, Aromatics, Pharmaceuticals, Intermediates & Fine Chemicals