KIRENOL
- ₹8200 - ₹25600
- Product name: KIRENOL
- CAS: 52659-56-0
- MF: C20H34O4
- MW: 338.49
- EINECS:
- MDL Number:MFCD00210519
- Synonyms:(1R,3S,4aS,4bS,7S,10aS)-1,2,3,4,4a,4b,5,6,7,9,10,10a-Dodecahydro-3-hydroxy-7-[(R)-1,2-dihydroxyethyl]-1,4a,7-trimethylphenanthrene-1-methanol;Kirenol;KIRENOL(P);Kirel;1,7-PhenanthrenediMethanol,1,2,3,4,4a,4b,5,6,7,- 9,10,10a-dodecahydro-3-hydroxy-R7- (hydroxyMethyl)-1,4a,7-triMethyl-,(R7R,1R,- 3S,4aS,4bR,7S,10aS)-;1,7-Phenanthrenedimethanol, 1,2,3,4,4a,4b,5,6,7,9,10,10a-dodecahydro-3-hydroxy-α7-(hydroxymethyl)-1,4a,7-trimethyl-, (α7R,1R,3S,4aS,4bR,7S,10aS)-;(1R)-1-[(2S,4aR,4bS,6S,8R,8aS)-6-hydroxy-8-(hydroxymethyl)-2,4b,8-trimethyl-4,4a,5,6,7,8a,9,10-octahydro-3H-phenanthren-2-yl]ethane-1,2-diol;KirenolQ: What is Kirenol Q: What is the CAS Number of Kirenol Q: What is the storage condition of Kirenol Q: What are the applications of Kirenol
2 prices
Selected condition:
Brand
- TCI Chemicals (India)
Package
- 25MG
- 100MG
- ManufacturerTCI Chemicals (India)
- Product numberK0059
- Product descriptionKirenol min. 98.0 %
- Packaging25MG
- Price₹8200
- Updated2022-05-26
- Buy
- ManufacturerTCI Chemicals (India)
- Product numberK0059
- Product descriptionKirenol min. 98.0 %
- Packaging100MG
- Price₹25600
- Updated2022-05-26
- Buy
Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|
TCI Chemicals (India) | K0059 | Kirenol min. 98.0 % | 25MG | ₹8200 | 2022-05-26 | Buy |
TCI Chemicals (India) | K0059 | Kirenol min. 98.0 % | 100MG | ₹25600 | 2022-05-26 | Buy |
Properties
Melting point :197.0 to 201.0 °C
Boiling point :516.9±35.0 °C(Predicted)
Density :1.17±0.1 g/cm3(Predicted)
storage temp. :-20°C Freezer
solubility :Ethanol (Slightly), Methanol (Slightly)
form :Solid
pka :14.06±0.20(Predicted)
color :White to Light Yellow
CAS DataBase Reference :52659-56-0
Boiling point :516.9±35.0 °C(Predicted)
Density :1.17±0.1 g/cm3(Predicted)
storage temp. :-20°C Freezer
solubility :Ethanol (Slightly), Methanol (Slightly)
form :Solid
pka :14.06±0.20(Predicted)
color :White to Light Yellow
CAS DataBase Reference :52659-56-0
Safety Information
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Description
Kirenol is a diterpenoid that has been found in S. orientalis and has diverse biological activities, including anti-arthritic and anti-inflammatory properties. It inhibits Gram-positive and Gram-negative bacterial growth in disc diffusion assays with MICs ranging from 39 to 156 and 312.5 to 625 μg/ml, respectively. Kirenol also reduces K652 chronic myeloid leukemia cell viability with a 48 hour IC50 value of 18.19 μg/ml and induces apoptosis. In vivo, kirenol (2 mg/kg, p.o.) reduces motor deficit, delays disease onset by approximately five days, and downregulates inflammatory CD4+IFN-γ+ Th1 cells and CD4+IL-17A+ Th17 cells in a mouse model of experimental autoimmune encephalomyelitis (EAE). Intragastric administration of kirenol (1-4 mg/kg) reduces the arthritis index, NF-kB activity, and paw swelling and increases annexin-1 expression without affecting glucocorticoid receptor α (GRα) expression in the synovium in a rat model of collagen-induced arthritis. Topical administration of kirenol (0.3-0.5% w/w) reduces edema induced by carrageenan, complete Freund''s adjuvant (CFA), and formalin in rats up to 44, 67, and 65%, respectively.More related product prices
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Suppliers and manufacturers
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