Liproxstatin-1
- ₹11431.2 - ₹46547.5
- Product name: Liproxstatin-1
- CAS: 950455-15-9
- MF: C19H21ClN4
- MW: 340.85
- EINECS:
- MDL Number:MFCD14948691
- Synonyms:Liproxstatin-1;N-[(3-chlorophenyl)methyl]-spiro[piperidine-4,2'(1'H)-quinoxalin]-3'-amine;N-(3-Chlorobenzyl)-1'H-spiro[piperidine-4,2'-quinoxalin]-3'-amine;LIPROXSTATIN-1;LIPROXSTATIN1;CS-1656;N-[(3-chlorophenyl)methyl]spiro[4H-quinoxaline-3,4'-piperidine]-2-amine;Liproxstatin-1 USP/EP/BP;N-[(3-chlorophenyl)methyl]-1'H-spiro[piperidine-4,2'-quinoxaline]-3'-amine
2 prices
Selected condition:
Brand
- Sigma-Aldrich(India)
Package
- 5MG
- 25MG
- ManufacturerSigma-Aldrich(India)
- Product numberSML1414
- Product descriptionLiproxstatin-1 >98% (HPLC)
- Packaging5MG
- Price₹11431.2
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberSML1414
- Product descriptionLiproxstatin-1 >98% (HPLC)
- Packaging25MG
- Price₹46547.5
- Updated2022-06-14
- Buy
Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|
Sigma-Aldrich(India) | SML1414 | Liproxstatin-1 >98% (HPLC) | 5MG | ₹11431.2 | 2022-06-14 | Buy |
Sigma-Aldrich(India) | SML1414 | Liproxstatin-1 >98% (HPLC) | 25MG | ₹46547.5 | 2022-06-14 | Buy |
Properties
Boiling point :581.4±50.0 °C(Predicted)
Density :1.32±0.1 g/cm3(Predicted)
storage temp. :-20°C
solubility :Soluble in DMSO (15 mg/ml)
form :powder
pka :9.45±0.40(Predicted)
color :white to light brown
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 month.
Density :1.32±0.1 g/cm3(Predicted)
storage temp. :-20°C
solubility :Soluble in DMSO (15 mg/ml)
form :powder
pka :9.45±0.40(Predicted)
color :white to light brown
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 month.
Safety Information
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Description
Ferroptosis is a regulated, non-apoptotic form of cell death involving the production of iron-dependent reactive oxygen species (ROS). Glutathione peroxidase 4 (Gpx4) is an essential regulator of ferroptotic cell death, playing a critical role in preventing ROS-induced lipid peroxidation. Liproxstatin-1 is an inhibitor of ferroptosis induced in mouse embryonic fibroblasts (MEFs) by Gpx4 deletion (IC50 = 22 nM). It does not interfere with apoptosis, necroptosis, or necrosis. Liproxstatin-1 also blocks ferroptosis induced by specific ferroptosis inducers, including the glutathioine-depleting agents BSO and erastin and the Gpx4 inhibitor RSL3. It is effective in vivo when administered intraperitoneally, suppressing ferroptosis in Gpx4-/- mice and in a mouse model of ischemia/reperfusion-induced liver injury.More related product prices
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