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ChemicalBook > Product Catalogue >API >Nervous system drugs >Antipsychotics >lurasidone

lurasidone

lurasidone Structure
  • ₹0
  • Product name: lurasidone
  • CAS: 367514-87-2
  • MF: C28H36N4O2S
  • MW: 492.68
  • EINECS:696-042-8
  • MDL Number:MFCD14635357
  • Synonyms:4-{[(1R,2R)-2-{[4-(2$l^{4}-thia-6-azatricyclo[5.4.0.0^{2,6}]undeca-1(11),2,4,7,9-pentaen-5-yl)piperazin-1-yl]Methyl}cyclohexyl]Methyl}-4-azatricyclo[5.2.1.0^{2,6}]deca-1(9),2(6),7-triene-3,5-dione;lurasidone;(3aR,4S,7R,7aS)-2-[[(1R,2R)-2-[[4-(1,2-Benzisothiazol-3-yl)-1-piperazinyl]methyl]cyclohexyl]methyl]hexahydro-4,7-methano-1H-isoindole-1,3(2H)-dione;Lurasidone (SM13496);(3aR,4S,7R,7aS)-2-{[(1R,2R)-2-{[4-(1,2-benzothiazol-3-yl)piperazin-1-yl]Methyl}cyclohexyl]Methyl}hexahydro-1H-4,7-Methanoisoindole-1,3(2H)-dione;urasidone;Lurasidone, >=98%;Lurasidone Base
Properties Safety Information Description
Manufacturer Product number Product description Packaging Price Updated Buy

Properties

Melting point :146-149°C
Boiling point :623.4±55.0 °C(Predicted)
Density :1.273
storage temp. :-20°C Freezer
solubility :Chloroform (Slightly), DMSO (Slightly, Heated), Methanol (Slightly, Heated)
pka :8.41±0.50(Predicted)
form :Solid
color :White to Off-White
InChIKey :PQXKDMSYBGKCJA-CVTJIBDQSA-N
SMILES :C1(=O)[C@]2([H])[C@@]([H])([C@]3([H])C[C@@]2([H])CC3)C(=O)N1C[C@@H]1CCCC[C@H]1CN1CCN(C2C3=C(SN=2)C=CC=C3)CC1
CAS DataBase Reference :367514-87-2

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
Precautionary statements:
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

The atypical antipsychotic lurasidone (also known as SM-13496) was approved in the United States in 2010 as an oral agent for the treatment of patients with schizophrenia. Lurasidone has potent affinity for D2 (Ki= 1.7 nM) and 5-HT2A (Ki= 2.0 nM) receptors and acts as an antagonist at both receptors. It is also a partial agonist at the 5-HT1A receptor and, unlike other atypical agents, is a potent antagonist at the 5-HT7 receptor; both of these activities are thought to confer beneficial cognitive properties. Lurasidone is further differentiated by its lack of affinity for muscarinic and histamine H1 receptors and its weak affinity for the 5-HT2C receptor. Antagonism at H1 and 5-HT2C receptors has been implicated in weight gain associated with atypical agents, while muscarinic receptor antagonism is associated with cognitive deficits.

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Suppliers and manufacturers

J S LABS KARPSCHEM LABORATORIES Glenmark Pharmaceuticals Limited Macleods Pharmaceuticals Limited Megafine Pharma Ralington Pharma Maps Laboratories Pvt Ltd Raks Pharma Pvt Ltd CLEARSYNTH LABS LTD. MSN LABORATORIES PRIVATE LTD