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ChemicalBook > Product Catalogue >API >Antineoplastic agents >Alkylating antineoplastic >Melphalan

Melphalan

Melphalan Structure
  • ₹17937.03 - ₹91016.6
  • Product name: Melphalan
  • CAS: 148-82-3
  • MF: C13H18Cl2N2O2
  • MW: 305.2
  • EINECS:205-726-3
  • MDL Number:MFCD00057717
  • Synonyms:L-PHENYL-ALANINE MUSTARD;L-PAM;at-290 ;cb3025 ;l-3-(p-(bis(2-chloroethyl)amino)phenyl)alanine ;l-3-(para-(bis(2-chloroethyl)amino)phenyl)alanine ;levofalan ;l-sarcolysin
3 prices
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Brand

  • Sigma-Aldrich(India)

Package

  • 100MG
  • 250MG
  • 1G
  • ManufacturerSigma-Aldrich(India)
  • Product numberM2011
  • Product descriptionMelphalan powder
  • Packaging100MG
  • Price₹17937.03
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberM2011
  • Product descriptionMelphalan powder
  • Packaging250MG
  • Price₹33405.95
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberM2011
  • Product descriptionMelphalan powder
  • Packaging1G
  • Price₹91016.6
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) M2011 Melphalan powder 100MG ₹17937.03 2022-06-14 Buy
Sigma-Aldrich(India) M2011 Melphalan powder 250MG ₹33405.95 2022-06-14 Buy
Sigma-Aldrich(India) M2011 Melphalan powder 1G ₹91016.6 2022-06-14 Buy

Properties

Melting point :~180 °C
Boiling point :473.1±45.0 °C(Predicted)
alpha :D25 +7.5° (c = 1.33 in 1.0N HCl); D22 -31.5° (c = 0.67 in methanol)
Density :1.3587 (rough estimate)
refractive index :1.6070 (estimate)
storage temp. :-20°C Freezer
solubility :95% ethanol and 1 drop 6 N HCl: 0.05 g/mL, clear
form :powder
pka :pKa 1.42/2.75/9.17(H2O,t =37.0,I=0.5) (Uncertain)
color :white
Water Solubility :<0.1 g/100 mL at 22 ºC
Merck :13,5850
BRN :2816456
InChIKey :SGDBTWWWUNNDEQ-LBPRGKRZSA-N
CAS DataBase Reference :148-82-3(CAS DataBase Reference)
IARC :1 (Vol. 9, Sup 7, 100A) 2012
EPA Substance Registry System :Melphalan (148-82-3)

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H300 Fatal if swallowed Acute toxicity,oral Category 1, 2 Danger GHS hazard pictograms P264, P270, P301+P310, P321, P330,P405, P501
H317 May cause an allergic skin reaction Sensitisation, Skin Category 1 Warning GHS hazard pictograms P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
H340 May cause genetic defects Germ cell mutagenicity Category 1A, 1B Danger GHS hazard pictograms
H350 May cause cancer Carcinogenicity Category 1A, 1B Danger GHS hazard pictograms
H361 Suspected of damaging fertility or the unborn child Reproductive toxicity Category 2 Warning P201, P202, P281, P308+P313, P405,P501
Precautionary statements:
P201 Obtain special instructions before use.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352 IF ON SKIN: wash with plenty of soap and water.

Description

Melphalan is a phenylalanine derivative of mechlorethamine, belonging to the family of nitrogen mustard alkylating agents that are used for chemotherapy. It attaches an alkyl group to guanine bases in DNA at the 7-nitrogen of the imidazole ring, which leads to DNA interstrand and intrastrand crosslinks, cytotoxicity, and apoptosis. Melphalan can inhibit the growth of PC-3 prostate cancer cells with IC50 values of 0.074 or 0.77 μM for sequential dosing or single dosing, respectively.

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