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METHOTREXATE HYDRATE

METHOTREXATE HYDRATE Structure
  • ₹2381.5 - ₹111432.55
  • Product name: METHOTREXATE HYDRATE
  • CAS: 133073-73-1
  • MF: C20H24N8O6
  • MW: 472.46
  • EINECS:625-397-3
  • MDL Number:MFCD00150847
  • Synonyms:l-4-amino-n10-methylpteroylglutamic acid;4-Amino-10-methylfolic acid hydrate, Antifolan hydrate, Methotrexate hydrate, Methylaminopterin hydrate, MTX hydrate, L-4-Amino-N10-methylpteroylglutamic acid hydrate;4-Amino-10-methylfolic acid hydrate, L-Amethopterin hydrate, Antifolan hydrate, Methylaminopterin hydrate, MTX hydrate, L-4-Amino-N10-methylpteroylglutamic acid hydrate;Methotrexate hydrate,4-Amino-10-methylfolic acid hydrate, L-4-Amino-N10-methylpteroylglutamic acid hydrate, L-Amethopterin hydrate, Antifolan hydrate, MTX hydrate, Methylaminopterin hydrate;Methotrexate hydrate,4-Amino-10-methylfolic acid hydrate, L-4-Amino-N10-methylpteroylglutamic acid hydrate, L-Amethopterin hydrate, Antifolan hydrate, MTX hydrate, Methotrexate hydrate, Methylaminopte;L(+)-AMethopterin hydrate, 99% 100MG;Methotrexate hydrate 4-AMino-10-Methylfolic acid hydrate;N-[4-[[(2,4-diaMino-6-pteridinyl)Methyl]MethylaMino]ben
24 prices
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Brand

  • Sigma-Aldrich(India)
  • TCI Chemicals (India)
  • ottokemi
  • SRL

Package

  • 5MG
  • 10MG
  • 25MG
  • 50mg
  • 100MG
  • 500MG
  • 1gm
  • 1G
  • 5G
  • 1Gms
  • ManufacturerSigma-Aldrich(India)
  • Product numberM8407
  • Product descriptionMethotrexate hydrate powder, BioReagent, suitable for cell culture, ≥98% (HPLC)
  • Packaging500MG
  • Price₹87401.05
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberM9929
  • Product descriptionMethotrexate meets USP testing specifications
  • Packaging500MG
  • Price₹78481.25
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberA6770
  • Product descriptionMethotrexate hydrate ≥98% (HPLC), powder
  • Packaging500MG
  • Price₹70752.2
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberM9929
  • Product descriptionMethotrexate meets USP testing specifications
  • Packaging100MG
  • Price₹29270.8
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberM8407
  • Product descriptionMethotrexate hydrate powder, BioReagent, suitable for cell culture, ≥98% (HPLC)
  • Packaging100MG
  • Price₹22169.6
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product number06563
  • Product descriptionMethotrexate hydrate ≥99.0% (sum of enantiomers, HPLC)
  • Packaging100MG
  • Price₹19236.03
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberA6770
  • Product descriptionMethotrexate hydrate ≥98% (HPLC), powder
  • Packaging1G
  • Price₹111432.55
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberA6770
  • Product descriptionMethotrexate hydrate ≥98% (HPLC), powder
  • Packaging100MG
  • Price₹17720.53
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberM9929
  • Product descriptionMethotrexate meets USP testing specifications
  • Packaging25MG
  • Price₹11939.98
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberA6770
  • Product descriptionMethotrexate hydrate ≥98% (HPLC), powder
  • Packaging25MG
  • Price₹7263.58
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product number06563
  • Product descriptionMethotrexate hydrate ≥99.0% (sum of enantiomers, HPLC)
  • Packaging25MG
  • Price₹7263.58
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberA6770
  • Product descriptionMethotrexate hydrate ≥98% (HPLC), powder
  • Packaging10MG
  • Price₹4600.63
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product number06563
  • Product descriptionMethotrexate hydrate ≥99.0% (sum of enantiomers, HPLC)
  • Packaging5MG
  • Price₹2381.5
  • Updated2022-06-14
  • Buy
  • ManufacturerTCI Chemicals (India)
  • Product numberM1664
  • Product descriptionMethotrexate Hydrate
  • Packaging5G
  • Price₹18300
  • Updated2022-05-26
  • Buy
  • ManufacturerTCI Chemicals (India)
  • Product numberM1664
  • Product descriptionMethotrexate Hydrate
  • Packaging1G
  • Price₹9000
  • Updated2022-05-26
  • Buy
  • Manufacturerottokemi
  • Product number M 4588
  • Product descriptionMethotrexate hydrate, ≥98% (HPLC), powder
  • Packaging1gm
  • Price₹109089
  • Updated2022-05-26
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) M8407 Methotrexate hydrate powder, BioReagent, suitable for cell culture, ≥98% (HPLC) 500MG ₹87401.05 2022-06-14 Buy
Sigma-Aldrich(India) M9929 Methotrexate meets USP testing specifications 500MG ₹78481.25 2022-06-14 Buy
Sigma-Aldrich(India) A6770 Methotrexate hydrate ≥98% (HPLC), powder 500MG ₹70752.2 2022-06-14 Buy
Sigma-Aldrich(India) M9929 Methotrexate meets USP testing specifications 100MG ₹29270.8 2022-06-14 Buy
Sigma-Aldrich(India) M8407 Methotrexate hydrate powder, BioReagent, suitable for cell culture, ≥98% (HPLC) 100MG ₹22169.6 2022-06-14 Buy
Sigma-Aldrich(India) 06563 Methotrexate hydrate ≥99.0% (sum of enantiomers, HPLC) 100MG ₹19236.03 2022-06-14 Buy
Sigma-Aldrich(India) A6770 Methotrexate hydrate ≥98% (HPLC), powder 1G ₹111432.55 2022-06-14 Buy
Sigma-Aldrich(India) A6770 Methotrexate hydrate ≥98% (HPLC), powder 100MG ₹17720.53 2022-06-14 Buy
Sigma-Aldrich(India) M9929 Methotrexate meets USP testing specifications 25MG ₹11939.98 2022-06-14 Buy
Sigma-Aldrich(India) A6770 Methotrexate hydrate ≥98% (HPLC), powder 25MG ₹7263.58 2022-06-14 Buy
Sigma-Aldrich(India) 06563 Methotrexate hydrate ≥99.0% (sum of enantiomers, HPLC) 25MG ₹7263.58 2022-06-14 Buy
Sigma-Aldrich(India) A6770 Methotrexate hydrate ≥98% (HPLC), powder 10MG ₹4600.63 2022-06-14 Buy
Sigma-Aldrich(India) 06563 Methotrexate hydrate ≥99.0% (sum of enantiomers, HPLC) 5MG ₹2381.5 2022-06-14 Buy
TCI Chemicals (India) M1664 Methotrexate Hydrate 5G ₹18300 2022-05-26 Buy
TCI Chemicals (India) M1664 Methotrexate Hydrate 1G ₹9000 2022-05-26 Buy
ottokemi M 4588 Methotrexate hydrate, ≥98% (HPLC), powder 1gm ₹109089 2022-05-26 Buy

Properties

Melting point :195 °C
storage temp. :-20°C
solubility :H2O: insoluble
form :powder
color :yellow
optical activity :[α]/D +21.0±2.0°
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
InChIKey :FBOZXECLQNJBKD-ZDUSSCGKSA-N

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H301 Toxic if swalloed Acute toxicity,oral Category 3 Danger GHS hazard pictograms P264, P270, P301+P310, P321, P330,P405, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
Precautionary statements:
P201 Obtain special instructions before use.
P202 Do not handle until all safety precautions have been read and understood.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Methotrexate (MTX) is similar in structure to folic acid and aminopterin . It acts by inhibiting the metabolism of folic acid and blocking key enzymes in the synthesis of purines and pyrimidines required for cell proliferation. MTX is known to induce adenosine release, which mediates many of its anti-inflammatory effects, including the reduction of proinflammatory cytokines. Formulations containing MTX have been used as immunosuppressants, in the treatment of cancer, autoimmune disease, ectopic pregnancy, and for the induction of medical abortions. MTX formulations have been considered the gold standard of disease-modifying antirheumatic drug (DMARD) therapy to treat both the immune-inflammatory and joint destructive processes of rheumatoid arthritis.

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