Welcome to chemicalbook!
China english Japan Germany India
400-158-6606
18162-48-6872-50-4Methylene ChloridenaphthaleneTHFTitanium Dioxide
Structured search
Inquriy
Try our best to find the right business for you.
Messages
Do not miss inquiry messages Please log in to view all inquiry messages.
head sculpture My chemicalbook

Welcome back!

RFQ
skype
MY Account
Top

MIRA-1

MIRA-1 Structure
  • ₹10670
  • Product name: MIRA-1
  • CAS: 72835-26-8
  • MF: C8H9NO4
  • MW: 183.16
  • EINECS:-0
  • MDL Number:MFCD12828765
  • Synonyms:MIRA-1;1-[(1-Oxopropoxy)methyl]-1H-pyrrole-2,5-dione;NSC 19630;1H-Pyrrole-2,5-dione, 1-[(1-oxopropoxy)methyl]-;Ethyl 2,5-Dioxo-2,5-dihydropyrrole-1-acetate;1-[(1-Oxopropoxy)methyl]-1H-pyrrole-2;5-dihydro-1H-pyrrol-1-yl)methyl propionate;p53 Activator VIII
Price1 Properties Safety Information Description
1 prices
Selected condition：

Brand

  • Sigma-Aldrich(India)

Package

  • 5MG
  • ManufacturerSigma-Aldrich(India)
  • Product number681647
  • Product descriptionWRN Helicase Inhibitor, NSC 19630 - CAS 72835-26-8 - Calbiochem The WRN Helicase Inhibitor, NSC 19630, also referenced under CAS 72835-26-8, controls the biological activity of WRN Helicase. This small molecule/inh
  • Packaging5MG
  • Price₹10670
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) 681647 WRN Helicase Inhibitor, NSC 19630 - CAS 72835-26-8 - Calbiochem The WRN Helicase Inhibitor, NSC 19630, also referenced under CAS 72835-26-8, controls the biological activity of WRN Helicase. This small molecule/inh 5MG ₹10670 2022-06-14 Buy

Properties

Melting point :44 °C
Boiling point :298.2±23.0 °C(Predicted)
Density :1.307±0.06 g/cm3(Predicted)
storage temp. :Store at +4°C
solubility :Soluble to 100 mM in DMSO and to 100 mM in ethanol
form :Powder
pka :-2.79±0.20(Predicted)
color :White to light yellow

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

MIRA-1 is a maleimide-derived small molecule that reactivates the tumor suppressor function of mutant p53, inducing apoptosis in several human solid tumor cell lines carrying tetracycline-regulated mutant p53 (IC50 = 10 μM in vitro). Treatment of tumor cells with MIRA-1 induces p21, MDM2 and PUMA in a mutant p53-dependent manner. At a concentration of 5-10 mg/kg, MIRA-1, alone or in combination with dexamethasone , arrested tumor growth in a mouse xenograft model of multiple myeloma.

Suppliers and manufacturers

TargetMol Chemicals Inc.
Aladdin Scientific
Suzhou ARTK Medchem Co., Ltd. Nantong QuanYi Biotechnology Co., Ltd Jiangsu Aikon Biopharmaceutical R&D Co.,Ltd. Shanghai SuperLan Chemcial Technique Centre Suzhou Zhixin Biotechnology Co., Ltd. Bide Pharmatech Ltd. Shanghai Aladdin Biochemical Technology Co.,Ltd. PharmaBlock Sciences (Nanjing), Inc.