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MIRA-1

MIRA-1 Structure
  • ₹10670
  • Product name: MIRA-1
  • CAS: 72835-26-8
  • MF: C8H9NO4
  • MW: 183.16
  • EINECS:-0
  • MDL Number:MFCD12828765
  • Synonyms:MIRA-1;1-[(1-Oxopropoxy)methyl]-1H-pyrrole-2,5-dione;NSC 19630;1H-Pyrrole-2,5-dione, 1-[(1-oxopropoxy)methyl]-;Ethyl 2,5-Dioxo-2,5-dihydropyrrole-1-acetate;1-[(1-Oxopropoxy)methyl]-1H-pyrrole-2;5-dihydro-1H-pyrrol-1-yl)methyl propionate;p53 Activator VIII
Price1 Properties Safety Information Description
1 prices
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Brand

  • Sigma-Aldrich(India)

Package

  • 5MG
  • ManufacturerSigma-Aldrich(India)
  • Product number681647
  • Product descriptionWRN Helicase Inhibitor, NSC 19630 - CAS 72835-26-8 - Calbiochem The WRN Helicase Inhibitor, NSC 19630, also referenced under CAS 72835-26-8, controls the biological activity of WRN Helicase. This small molecule/inh
  • Packaging5MG
  • Price₹10670
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) 681647 WRN Helicase Inhibitor, NSC 19630 - CAS 72835-26-8 - Calbiochem The WRN Helicase Inhibitor, NSC 19630, also referenced under CAS 72835-26-8, controls the biological activity of WRN Helicase. This small molecule/inh 5MG ₹10670 2022-06-14 Buy

Properties

Melting point :44 °C
Boiling point :298.2±23.0 °C(Predicted)
Density :1.307±0.06 g/cm3(Predicted)
storage temp. :Store at +4°C
solubility :Soluble to 100 mM in DMSO and to 100 mM in ethanol
form :Powder
pka :-2.79±0.20(Predicted)
color :White to light yellow

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

MIRA-1 is a maleimide-derived small molecule that reactivates the tumor suppressor function of mutant p53, inducing apoptosis in several human solid tumor cell lines carrying tetracycline-regulated mutant p53 (IC50 = 10 μM in vitro). Treatment of tumor cells with MIRA-1 induces p21, MDM2 and PUMA in a mutant p53-dependent manner. At a concentration of 5-10 mg/kg, MIRA-1, alone or in combination with dexamethasone , arrested tumor growth in a mouse xenograft model of multiple myeloma.

Suppliers and manufacturers

TargetMol Chemicals Inc.
MIRA-1
₹34.00 /2mg
MIRA-1 CAS:72835-26-8
Aladdin Scientific
Suzhou ARTK Medchem Co., Ltd. Nantong QuanYi Biotechnology Co., Ltd Jiangsu Aikon Biopharmaceutical R&D Co.,Ltd. Bide Pharmatech Ltd. TargetMol Chemicals Inc. Shanghai Aladdin Biochemical Technology Co.,Ltd. PharmaBlock Sciences (Nanjing), Inc. RD International Technology Co., Limited