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NSC 600157

NSC 600157 Structure
  • ₹9991.48 - ₹110566.55
  • Product name: NSC 600157
  • CAS: 31083-55-3
  • MF: C15H9NO2
  • MW: 235.24
  • EINECS:
  • MDL Number:MFCD00435709
  • Synonyms:2-(3-Pyridinylmethylene)-1H-indene-1,3(2H)-dione;2-(3-Pyridylmethylene)-1,3-indandione;NSC 600157;PRT4165;PRT 4165(NSC 600157);PRT 4165; PRT-4165; NSC600157; NSC-600157; NSC 600157; 2-(pyridin-3-ylmethylidene)indene-1,3-dione;1H-Indene-1,3(2H)-dione, 2-(3-pyridinylmethylene)-
Price3 Properties Safety Information Description
3 prices
Selected condition：

Brand

  • Sigma-Aldrich(India)

Package

  • 5MG
  • 25MG
  • 1G
  • ManufacturerSigma-Aldrich(India)
  • Product numberSML1013
  • Product descriptionPRT4165 ≥98% (HPLC)
  • Packaging5MG
  • Price₹9991.48
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberSML1013
  • Product descriptionPRT4165 ≥98% (HPLC)
  • Packaging25MG
  • Price₹40680.35
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberEME00468
  • Product description(2E)-2-(Pyridin-3-ylmethylidene)-2,3-dihydro-1H-indene-1,3-dione
  • Packaging1G
  • Price₹110566.55
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) SML1013 PRT4165 ≥98% (HPLC) 5MG ₹9991.48 2022-06-14 Buy
Sigma-Aldrich(India) SML1013 PRT4165 ≥98% (HPLC) 25MG ₹40680.35 2022-06-14 Buy
Sigma-Aldrich(India) EME00468 (2E)-2-(Pyridin-3-ylmethylidene)-2,3-dihydro-1H-indene-1,3-dione 1G ₹110566.55 2022-06-14 Buy

Properties

Melting point :154-161 °C(Solv: ethanol (64-17-5))
Boiling point :377.63°C (rough estimate)
Density :1.1757 (rough estimate)
refractive index :1.6231 (estimate)
storage temp. :2-8°C
solubility :DMSO: soluble20mg/mL, clear
form :powder
pka :3.24±0.12(Predicted)
color :white to beige
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H317 May cause an allergic skin reaction Sensitisation, Skin Category 1 Warning GHS hazard pictograms P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
Precautionary statements:
P280 Wear protective gloves/protective clothing/eye protection/face protection.

Description

BMI1/RING1A and BMI1/RNF2 are E3 ubiquitin ligase complexes that mediate the monoubiquitination of histone 2A (H2A). This is an essential function of polycomb repressive complex 1 (PRC1). PRT4165 is an inhibitor of the ubiquitin ligase activity of PRC1. It blocks BMI1/RING1A self-ubiquitination (IC50 = 3.9 μM), as well as polyubiquitination of topoisomerase 2α in cells. PRT4165 inhibits ubiquitination of H2A by either RNF2 or RING1. Through these actions, PRT4165 prevents the accumulation of detectable ubiquitin at DNA double-strand breaks, the retention of response proteins around breaks, and the repair of breaks.

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2-(pyridin-3-ylmethylidene)indene-1,3-dione
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2-(pyridin-3-ylmethylidene)indene-1,3-dione CAS:31083-55-3
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