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ChemicalBook > Product Catalogue >Biochemical Engineering >Inhibitors >Epigenetics >Histone Acetyltransferase inhibitors >C 646

C 646

C 646 Structure
  • ₹13100 - ₹64841.75
  • Product name: C 646
  • CAS: 328968-36-1
  • MF: C24H19N3O6
  • MW: 445.42
  • EINECS:
  • MDL Number:MFCD01784780
  • Synonyms:C 646;(E)-4-(4-((5-(4,5-diMethyl-2-nitrophenyl)furan-2-yl)Methylene)-3-Methyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl)benzoic acid;(Z)-4-(4-((5-(4,5-diMethyl-2-nitrophenyl)furan-2-yl)Methylene)-3-Methyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl)benzoic acid;4-[4-[[5-(4,5-Dimethyl-2-nitrophenyl)-2-furanyl]methylene]-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl]-benzoic acid;Benzoic acid, 4-[4-[[5-(4,5-dimethyl-2-nitrophenyl)-2-furanyl]methylene]-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl]-;4-[4-[[5-(4,5-Dimethyl-2-nitrophenyl)-2-furanyl]methylene]-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl]-benzoic acid C646;C 646 4-[4-[[5-(4,5-Dimethyl-2-nitrophenyl)-2-furanyl]methylene]-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl]-benzoic acid;C646, p300/CBP Inhibitor
Price3 Properties Safety Information Description
3 prices
Selected condition：

Brand

  • Sigma-Aldrich(India)

Package

  • 5MG
  • 10MG
  • 25MG
  • ManufacturerSigma-Aldrich(India)
  • Product number382113
  • Product descriptionHistone Acetyltransferase p300 Inhibitor, C646 - Calbiochem Histone Acetyltransferase p300 Inhibitor, C646, CAS 328968-36-1, is a cell-permeable, reversible inhibitor of p300/CBP HAT (Ki = 400 nM). Competes wit
  • Packaging10MG
  • Price₹13100
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberSML0002
  • Product descriptionC646 ≥98% (HPLC)
  • Packaging5MG
  • Price₹16973.6
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberSML0002
  • Product descriptionC646 ≥98% (HPLC)
  • Packaging25MG
  • Price₹64841.75
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) 382113 Histone Acetyltransferase p300 Inhibitor, C646 - Calbiochem Histone Acetyltransferase p300 Inhibitor, C646, CAS 328968-36-1, is a cell-permeable, reversible inhibitor of p300/CBP HAT (Ki = 400 nM). Competes wit 10MG ₹13100 2022-06-14 Buy
Sigma-Aldrich(India) SML0002 C646 ≥98% (HPLC) 5MG ₹16973.6 2022-06-14 Buy
Sigma-Aldrich(India) SML0002 C646 ≥98% (HPLC) 25MG ₹64841.75 2022-06-14 Buy

Properties

Melting point :224-226℃
Boiling point :662.6±65.0 °C(Predicted)
Density :1.38±0.1 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: >25mg/mL
form :powder
pka :4.20±0.10(Predicted)
color :red to brown
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 2 months.
InChIKey :HEKJYZZSCQBJGB-XDHOZWIPSA-N

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

C646 is an inhibitor of the histone acetyltransferase p300 (IC50 = 1.6 μM). It competitively (versus acetyl-CoA) binds p300 (Ki = 400 nM) and does not inhibit several other acetyltransferases. The action of C646 appears to be irreversible through covalent modification of the enzyme target. It blocks the growth of human melanoma, leukemia, lung, and prostate cancer cells in vitro. C646 has been used to study the role of p300-mediated acetylation in such models as fear extinction memory and the regulation of immediate-early genes.

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