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C 646

CAS No.: 328968-36-1

Chemical Name:: C 646

Synonyms: 104475;C647;C 646;CS-1006;C274682;C-646;C 646;C 646 USP/EP/BP;C646 C-646 C 646;C646, p300/CBP Inhibitor;Histone Acetyltransferase p300 Inhibitor, C646 - Calbiochem

CBNumber:: CB62535667

Molecular Formula:: C24H19N3O6

Molecular Weight:: 445.42

MOL File:: 328968-36-1.mol

MSDS File:: SDS

Modify Date:: 2023/6/30 15:45:59

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C 646 Properties

Melting point	224-226℃
Boiling point	662.6±65.0 °C(Predicted)
Density	1.38±0.1 g/cm3(Predicted)
storage temp.	2-8°C
solubility	DMSO: >25mg/mL
form	powder
pka	4.20±0.10(Predicted)
color	red to brown
Stability	Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 2 months.
InChIKey	HEKJYZZSCQBJGB-XDHOZWIPSA-N

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P305+P351+P338
Hazard Codes	N
Risk Statements	50
Safety Statements	61
RIDADR	UN 3077 9 / PGIII
WGK Germany	3

C 646 price More Price(3)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich(India)	SML0002	C646 ≥98% (HPLC)	328968-36-1	5MG	₹16973.6	2022-06-14	Buy
Sigma-Aldrich(India)	SML0002	C646 ≥98% (HPLC)	328968-36-1	25MG	₹64841.75	2022-06-14	Buy
Sigma-Aldrich(India)	382113	Histone Acetyltransferase p300 Inhibitor, C646 - Calbiochem Histone Acetyltransferase p300 Inhibitor, C646, CAS 328968-36-1, is a cell-permeable, reversible inhibitor of p300/CBP HAT (Ki = 400 nM). Competes wit	328968-36-1	10MG	₹13100	2022-06-14	Buy

Product number	Packaging	Price	Buy
SML0002	5MG	₹16973.6	Buy
SML0002	25MG	₹64841.75	Buy
382113	10MG	₹13100	Buy

C 646 Chemical Properties,Uses,Production

Uses

C646 is an inhibitor for histone acetyltransferase p300 and may be a potential candidate for treating AML1-ETO (AE) positive acute myeloid leukemia (AML). It is shown that C646 inhibited cellular proliferation, reduced colony formation, evoked partial cell cycle arrest in the G1 phase, and induced apoptosis in AE-positive AML cell lines and primary blasts isolated from leukemic mice and AML patients.

Definition

ChEBI: A pyrazolone that is 5-methyl-4-methylene-2-(p-carboxyphenyl)-2,4-dihydro-3H-pyrazol-3-one in which the exocyclic carbon of the methylene group is attached to a 5-(4,5-dimethyl-2-nitrophenyl)furan-2-yl group by a single bond C646 is a potent, cell permeable and selective competitive inhibitor of p300 and CBP (p300/CBP) histone acetyltransferases.

Biochem/physiol Actions

C646 is a potent, cell permeable and selective inhibitor of p300 and CBP (p300/CBP) histone acetyltransferases. Inhibition of p300/CBP by C646 affects the activity of a variety of transcriptional factors such as NF-κB, p53 and MyoD that are associated with physiology, disease processes, hippocampal synaptic plasticity, spatial memory and contextual fear.

C 646 Preparation Products And Raw materials

Raw materials

Preparation Products

C 646 Suppliers

Global( 133)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
CLEARSYNTH LABS LTD.	+91-22-45045900	Hyderabad, India	6351	58	Inquiry
A.J Chemicals	91-9810153283	New Delhi, India	6124	58	Inquiry
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	China	32760	60	Inquiry
BOC Sciences	+1-631-485-4226	United States	19553	58	Inquiry
career henan chemical co	+86-0371-86658258 +8613203830695	China	29826	58	Inquiry
SHANGHAI T&W PHARMACEUTICAL CO., LTD.	+86-021-61551413 +8618813727289	China	5738	58	Inquiry
Tianjin Xinshengjiahe Science & Technology Development Co,.Ltd	+86-86-22-87899925 +86-8618522618860	China	694	58	Inquiry
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	United States	19892	58	Inquiry
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	China	25247	58	Inquiry
Baoji Guokang Bio-Technology Co., Ltd.	0917-3909592 13892490616	China	9322	58	Inquiry

Supplier	Advantage
CLEARSYNTH LABS LTD.	58
A.J Chemicals	58
ATK CHEMICAL COMPANY LIMITED	60
BOC Sciences	58
career henan chemical co	58
SHANGHAI T&W PHARMACEUTICAL CO., LTD.	58
Tianjin Xinshengjiahe Science & Technology Development Co,.Ltd	58
TargetMol Chemicals Inc.	58
Dideu Industries Group Limited	58
Baoji Guokang Bio-Technology Co., Ltd.	58

C 646 Spectrum

C 646(328968-36-1)¹HNMR

328968-36-1(C 646)Related Search:

TCPOBOP CYCLOPAMINE Adapalene (E)-3-[[[3-[2-(7-CHLORO-2-QUINOLINYL)ETHENYL]PHENYL]-[[(3-DIMETHYLAMINO)-3-OXOPROPYL]THIO]METHYL]THIO]-PROPANOIC ACID, SODIUM SALT TRICHOSTATIN A

MG149 GSK J4 HCl 6-CHLORO-2,3,4,9-TETRAHYDRO-1H-CARBAZOLE-1-CARBOXAMIDE (2R,3R,4S,5R)-2-(6-aMino-9H-purin-9-yl)-5-((((1r,3S)-3-(2-(5-(tert-butyl)-1H-benzo[d]iMidazol-2-yl)ethyl)cyclobutyl)(isopropyl)aMino)Methyl)tetrahydrofuran-3,4-diol LY 294002 HYDROCHLORIDE

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C 646 (E)-4-(4-((5-(4,5-diMethyl-2-nitrophenyl)furan-2-yl)Methylene)-3-Methyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl)benzoic acid (Z)-4-(4-((5-(4,5-diMethyl-2-nitrophenyl)furan-2-yl)Methylene)-3-Methyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl)benzoic acid 4-[4-[[5-(4,5-Dimethyl-2-nitrophenyl)-2-furanyl]methylene]-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl]-benzoic acid Benzoic acid, 4-[4-[[5-(4,5-dimethyl-2-nitrophenyl)-2-furanyl]methylene]-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl]- 4-[4-[[5-(4,5-Dimethyl-2-nitrophenyl)-2-furanyl]methylene]-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl]-benzoic acid C646 C 646 4-[4-[[5-(4,5-Dimethyl-2-nitrophenyl)-2-furanyl]methylene]-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl]-benzoic acid C646, p300/CBP Inhibitor 4-(4-((5-(4,5-Dimethyl-2-nitrophenyl)furan-2-yl)methylene)-3-methyl-5-oxo-4,5-dihydro-1H-pyraz Histone Acetyltransferase p300 Inhibitor, C646 - Calbiochem 4-[(4Z)-4-[[5-(4,5-dimethyl-2-nitrophenyl)furan-2-yl]methylidene]-3-methyl-5-oxopyrazol-1-yl]benzoic acid CS-1006 C-646;C 646 4-(4-((5-(4,5-dimethyl-2-nitrophenyl)furan-2-yl)methylene)-3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl)benzoic acid C646 C-646 C 646 C 646 USP/EP/BP C647 104475 Histone Acetyltransferase,Inhibitor,HATs,C646,Autophagy,C-646,HAT,inhibit,Epigenetic Reader Domain,C 646,Apoptosis C274682 328968-36-1 Inhibitors