C 646
- ₹13100 - ₹64841.75
- Product name: C 646
- CAS: 328968-36-1
- MF: C24H19N3O6
- MW: 445.42
- EINECS:
- MDL Number:MFCD01784780
- Synonyms:C 646;(E)-4-(4-((5-(4,5-diMethyl-2-nitrophenyl)furan-2-yl)Methylene)-3-Methyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl)benzoic acid;(Z)-4-(4-((5-(4,5-diMethyl-2-nitrophenyl)furan-2-yl)Methylene)-3-Methyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl)benzoic acid;4-[4-[[5-(4,5-Dimethyl-2-nitrophenyl)-2-furanyl]methylene]-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl]-benzoic acid;Benzoic acid, 4-[4-[[5-(4,5-dimethyl-2-nitrophenyl)-2-furanyl]methylene]-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl]-;4-[4-[[5-(4,5-Dimethyl-2-nitrophenyl)-2-furanyl]methylene]-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl]-benzoic acid C646;C 646 4-[4-[[5-(4,5-Dimethyl-2-nitrophenyl)-2-furanyl]methylene]-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl]-benzoic acid;C646, p300/CBP Inhibitor
3 prices
Selected condition:
Brand
- Sigma-Aldrich(India)
Package
- 5MG
- 10MG
- 25MG
- ManufacturerSigma-Aldrich(India)
- Product number382113
- Product descriptionHistone Acetyltransferase p300 Inhibitor, C646 - Calbiochem Histone Acetyltransferase p300 Inhibitor, C646, CAS 328968-36-1, is a cell-permeable, reversible inhibitor of p300/CBP HAT (Ki = 400 nM). Competes wit
- Packaging10MG
- Price₹13100
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberSML0002
- Product descriptionC646 ≥98% (HPLC)
- Packaging5MG
- Price₹16973.6
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberSML0002
- Product descriptionC646 ≥98% (HPLC)
- Packaging25MG
- Price₹64841.75
- Updated2022-06-14
- Buy
Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|
Sigma-Aldrich(India) | 382113 | Histone Acetyltransferase p300 Inhibitor, C646 - Calbiochem Histone Acetyltransferase p300 Inhibitor, C646, CAS 328968-36-1, is a cell-permeable, reversible inhibitor of p300/CBP HAT (Ki = 400 nM). Competes wit | 10MG | ₹13100 | 2022-06-14 | Buy |
Sigma-Aldrich(India) | SML0002 | C646 ≥98% (HPLC) | 5MG | ₹16973.6 | 2022-06-14 | Buy |
Sigma-Aldrich(India) | SML0002 | C646 ≥98% (HPLC) | 25MG | ₹64841.75 | 2022-06-14 | Buy |
Properties
Melting point :224-226℃
Boiling point :662.6±65.0 °C(Predicted)
Density :1.38±0.1 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: >25mg/mL
form :powder
pka :4.20±0.10(Predicted)
color :red to brown
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 2 months.
InChIKey :HEKJYZZSCQBJGB-XDHOZWIPSA-N
Boiling point :662.6±65.0 °C(Predicted)
Density :1.38±0.1 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: >25mg/mL
form :powder
pka :4.20±0.10(Predicted)
color :red to brown
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 2 months.
InChIKey :HEKJYZZSCQBJGB-XDHOZWIPSA-N
Safety Information
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Signal word: | Warning | |||||||||||||||||||||||||||||||||||
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Description
C646 is an inhibitor of the histone acetyltransferase p300 (IC50 = 1.6 μM). It competitively (versus acetyl-CoA) binds p300 (Ki = 400 nM) and does not inhibit several other acetyltransferases. The action of C646 appears to be irreversible through covalent modification of the enzyme target. It blocks the growth of human melanoma, leukemia, lung, and prostate cancer cells in vitro. C646 has been used to study the role of p300-mediated acetylation in such models as fear extinction memory and the regulation of immediate-early genes.More related product prices
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Suppliers and manufacturers
career henan chemical co
CLEARSYNTH LABS LTD.
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₹1.00 /1KG
4-[(4Z)-4-[[5-(4,5-dimethyl-2-nitrophenyl)furan-2-yl]methylidene]-3-methyl-5-oxopyrazol-1-yl]benzoic acid CAS:328968-36-1
4-[(4Z)-4-[[5-(4,5-dimethyl-2-nitrophenyl)furan-2-yl]methylidene]-3-methyl-5-oxopyrazol-1-yl]benzoic acid CAS:328968-36-1