NSC 663284
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- ₹20643.28 - ₹78481.25
- Product name: NSC 663284
- CAS: 383907-43-5
- MF: C15H16ClN3O3
- MW: 321.76
- EINECS:
- MDL Number:MFCD08276924
- Synonyms:CDC25 Phosphatase Inhibitor II, NSC 663284 - CAS 383907-43-5 - Calbiochem;5,8-Quinolinedione, 6-chloro-7-[[2-(4-morpholinyl)ethyl]amino]-;CDC25 Phosphatase Inhibitor II, NSC 663284;NSC 663284 (DA3003-1)
3 prices
Selected condition：
Brand
- Sigma-Aldrich(India)
Package
- 5MG
- 25MG
- ManufacturerSigma-Aldrich(India)
- Product numberN7537
- Product descriptionNSC 663284 ≥98% (HPLC), solid
- Packaging5MG
- Price₹20643.28
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product number217692
- Product descriptionCDC25 Phosphatase Inhibitor II, NSC 663284 - CAS 383907-43-5 - Calbiochem The CDC25 Phosphatase Inhibitor II, NSC 663284, also referenced under CAS 383907-43-5, controls the biological activity of CDC25 Phosphatase. This sma
- Packaging5MG
- Price₹26250
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberN7537
- Product descriptionNSC 663284 ≥98% (HPLC), solid
- Packaging25MG
- Price₹78481.25
- Updated2022-06-14
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | N7537 | NSC 663284 ≥98% (HPLC), solid | 5MG | ₹20643.28 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 217692 | CDC25 Phosphatase Inhibitor II, NSC 663284 - CAS 383907-43-5 - Calbiochem The CDC25 Phosphatase Inhibitor II, NSC 663284, also referenced under CAS 383907-43-5, controls the biological activity of CDC25 Phosphatase. This sma | 5MG | ₹26250 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | N7537 | NSC 663284 ≥98% (HPLC), solid | 25MG | ₹78481.25 | 2022-06-14 | Buy |
Properties
Boiling point :478.8±45.0 °C(Predicted)
Density :1.41±0.1 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: 16 mg/mL
form :solid
pka :6.79±0.10(Predicted)
color :red
Sensitive :Light Sensitive
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
Density :1.41±0.1 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: 16 mg/mL
form :solid
pka :6.79±0.10(Predicted)
color :red
Sensitive :Light Sensitive
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
Safety Information
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Description
Three genes encode dual specificity phosphatases that are Cdc25 homologs. The phosphatases, Cdc25A through C, are proto-oncogenes and are often over-expressed in cancers. NSC 663284 is a potent, cell-permeable, and irreversible inhibitor of all Cdc25 isoforms, with preference for Cdc25A (IC50 = 29, 95, and 89 nM for Cdc25A, Cdc25B2, and Cdc25C, respectively). NSC 663284 poorly inhibits other phosphatases, including Vaccinia virus VH1-related (IC50 = 4.0 μM), PTP1B (no inhibition), and the mitogen-activated protein kinase phosphatases (MKP) MKP-1 or -3 (no inhibition). By inhibiting Cdc25 isoforms, NSC 663284 prevents the dephosphorylation and activation of Cdk1 and Cdk2, arrests cells at both G1 and G2/M phases, and prevents the proliferation of several human tumor cell lines.Related product price
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