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ChemicalBook > Product Catalogue >Biochemical Engineering >Biological response modifiers >Pidotimod

Pidotimod

Pidotimod Structure
  • ₹8000 - ₹43613.93
  • Product name: Pidotimod
  • CAS: 121808-62-6
  • MF: C9H12N2O4S
  • MW: 244.27
  • EINECS:2017-001-1
  • MDL Number:MFCD00867583
  • Synonyms:(4R)-3-[(2S)-5-Oxopyrrolidine-2-carbonyl]-1,3-thiazolidine-4-carboxylic acid;(4S)-3-(5-Oxo-L-prolyl)thiazolidine-4-carboxylic acid;3-Pyroglutamoylthiazolidine-4-carboxylic acid;(4R)-3-[(2S)-5-ketopyrrolidine-2-carbonyl]thiazolidine-4-carboxylic acid;(4R)-3-[(2S)-5-oxopyrrolidin-2-yl]carbonyl-1,3-thiazolidine-4-carboxylic acid;(R)-3-((S)-5-Oxopyrrolidine-2-carbonyl)thiazolidine-4-carboxylic acid;Axil;Onaka
Price4 Properties Safety Information Description
4 prices
Selected condition：

Brand

  • TCI Chemicals (India)
  • Sigma-Aldrich(India)

Package

  • 50MG
  • 250MG
  • 5G
  • 25G
  • ManufacturerTCI Chemicals (India)
  • Product numberP2147
  • Product descriptionPidotimod
  • Packaging5G
  • Price₹8000
  • Updated2022-05-26
  • Buy
  • ManufacturerTCI Chemicals (India)
  • Product numberP2147
  • Product descriptionPidotimod
  • Packaging25G
  • Price₹16300
  • Updated2022-05-26
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberSML1335
  • Product descriptionPidotimod ≥98% (HPLC)
  • Packaging50MG
  • Price₹10825
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberSML1335
  • Product descriptionPidotimod ≥98% (HPLC)
  • Packaging250MG
  • Price₹43613.93
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
TCI Chemicals (India) P2147 Pidotimod 5G ₹8000 2022-05-26 Buy
TCI Chemicals (India) P2147 Pidotimod 25G ₹16300 2022-05-26 Buy
Sigma-Aldrich(India) SML1335 Pidotimod ≥98% (HPLC) 50MG ₹10825 2022-06-14 Buy
Sigma-Aldrich(India) SML1335 Pidotimod ≥98% (HPLC) 250MG ₹43613.93 2022-06-14 Buy

Properties

Melting point :194-198°C (dec.)
alpha :D25 -150° (c = 2 in 5N HCl)
Boiling point :663.0±55.0 °C(Predicted)
Density :1.53
storage temp. :Keep in dark place,Sealed in dry,2-8°C
solubility :DMSO (Slightly, Heated), Methanol (Slightly, Heated), 5N HCl (Slightly)
form :powder
pka :3.03(at 25℃)
color :white to beige
optical activity :[α]/D -135 to -155°, c = 1 in 6 M HCl
Merck :14,7419
InChI :InChI=1S/C9H12N2O4S/c12-7-2-1-5(10-7)8(13)11-4-16-3-6(11)9(14)15/h5-6H,1-4H2,(H,10,12)(H,14,15)/t5-,6-/m0/s1
InChIKey :UUTKICFRNVKFRG-WDSKDSINSA-N
SMILES :S1C[C@@H](C(O)=O)N(C([C@@H]2CCC(=O)N2)=O)C1
CAS DataBase Reference :121808-62-6(CAS DataBase Reference)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Pidotimod is a synthetic dipeptide with immunomodulatory properties on both innate and adaptive immune responses in in vitro studies. It has been shown to induce dendritic cell (DC) maturation, to upregulate the expression of HLA-DR and co-stimulatory molecules CD83 and CD86, to stimulate the release of pro-inflammatory molecules from DCs, which drives T cell proliferation and differentiation towards a Th1 phenotype, to enhance natural killer cell functions, to inhibit thymocyte apoptosis, and to promote phagocytosis. Through separate effects on ERK1/2 and NF-κB, pidotimod was shown to increase the expression of toll-like receptor 2 proteins. Pimotimod does not affect expression of ICAM-1 or the release of IL-8.

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Suppliers and manufacturers

AnalyticsStanza Inc Lewens Labs JR Corporation Allastir Private Limited TCI Chemicals (India) Pvt. Ltd. Pharmaffiliates Analytics and Synthetics P. Ltd CAD Pharma Inc. Lewens Labs Clearsynth Labs Cleargreens Pharmaceutical Private Limited