ReModelin
|
- ₹13000.83 - ₹52360.53
- Product name: ReModelin
- CAS: 949912-58-7
- MF: C15H14N4S
- MW: 282.36
- EINECS:
- MDL Number:MFCD28167837
- Synonyms:ReModelin;4-[2-(2-Cyclopentylidenehydrazinyl)-4-thiazolyl]-benzonitrile hydrobromide;4-[2-(2-Cyclopentylidenehydrazinyl)-4-thiazolyl]benzonitrile;CS-2149;Benzonitrile, 4-[2-(2-cyclopentylidenehydrazinyl)-4-thiazolyl]-;Reaxys ID: 18559527;4-(2-(2-Cyclopentylidenehydrazineyl)thiazol-4-yl)benzonitrile;4- (2- (2-cyclopentylidenehydrazine) thiazol-4-yl) benzonitrile
2 prices
Selected condition：
Brand
- Sigma-Aldrich(India)
Package
- 5MG
- 25MG
- ManufacturerSigma-Aldrich(India)
- Product numberSML1112
- Product descriptionRemodelin hydrobromide ≥98% (HPLC)
- Packaging5MG
- Price₹13000.83
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberSML1112
- Product descriptionRemodelin hydrobromide ≥98% (HPLC)
- Packaging25MG
- Price₹52360.53
- Updated2022-06-14
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | SML1112 | Remodelin hydrobromide ≥98% (HPLC) | 5MG | ₹13000.83 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | SML1112 | Remodelin hydrobromide ≥98% (HPLC) | 25MG | ₹52360.53 | 2022-06-14 | Buy |
Properties
Boiling point :498.9±47.0 °C(Predicted)
Density :1.31±0.1 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: soluble20mg/mL, clear
form :powder
pka :14.40±0.20(Predicted)
color :white to beige
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Density :1.31±0.1 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: soluble20mg/mL, clear
form :powder
pka :14.40±0.20(Predicted)
color :white to beige
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Safety Information
| Symbol(GHS): |
|
||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal word: | Warning | ||||||||||||||
| Hazard statements: |
|
||||||||||||||
| Precautionary statements: |
|
Description
Progeria is a genetic disorder that results in the appearance of premature aging. Genetically, progeria is characterized by a mutation in lamin A, which results in misshapen cell nuclei and DNA damage. Remodelin is a 2-thiazolylhydrazone derivative that, at 10 μM, improves nuclear architecture, chromatin organization, and survival of both cells lacking lamin A and cells from patients with progeria. Remodelin is an inhibitor of N-acetyltransferase 10 (NAT10), which acetylates both histones and microtubules. Mutation of NAT10 mimics the effects of remodelin on nuclear morphology, suggesting that these effects of remodelin require NAT10. Remodelin also has cytotoxic effects against some species of the fungus Candida.Related product price
Suppliers and manufacturers
ATK CHEMICAL COMPANY LIMITED
Zhejiang J&C Biological Technology Co.,Limited
InvivoChem
TargetMol Chemicals Inc.
ShenZhen Trendseen Biological Technology Co.,Ltd.
Wuhan Topule Biopharmaceutical Co., Ltd
Aladdin Scientific
Amadis Chemical Company Limited
Angel Pharmatech, Ltd.
