SB 203580 (hydrochloride)
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- ₹15760 - ₹42220
- Product name: SB 203580 (hydrochloride)
- CAS: 869185-85-3
- MF: C21H17ClFN3OS
- MW: 413.9
- EINECS:
- MDL Number:MFCD01862622
- Synonyms:RWJ 64809 hydrochloride;RWJ 64809 HYDROCHLORIDE;SB203580 HYDROCHLORIDE;SB-203580 HYDROCHLORIDE;SB 203580, Hydrochloride - CAS 869185-85-3 - Calbiochem;Adezmapimod (hydrochloride);Adezmapimod (SB-203580) hydrochloride
2 prices
Selected condition:
Brand
- Sigma-Aldrich(India)
Package
- 1MG
- 10MG
- ManufacturerSigma-Aldrich(India)
- Product number559395
- Product descriptionSB 203580, Hydrochloride - CAS 869185-85-3 - Calbiochem SB 203580, Hydrochloride, CAS 869185-85-3, is a water-soluble form of SB 203580. A highly potent, selective, ATP-competitive inhibitor of p38 MAP Kina
- Packaging1MG
- Price₹15760
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product number559395
- Product descriptionSB 203580, Hydrochloride - CAS 869185-85-3 - Calbiochem SB 203580, Hydrochloride, CAS 869185-85-3, is a water-soluble form of SB 203580. A highly potent, selective, ATP-competitive inhibitor of p38 MAP Kina
- Packaging10MG
- Price₹42220
- Updated2022-06-14
- Buy
Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|
Sigma-Aldrich(India) | 559395 | SB 203580, Hydrochloride - CAS 869185-85-3 - Calbiochem SB 203580, Hydrochloride, CAS 869185-85-3, is a water-soluble form of SB 203580. A highly potent, selective, ATP-competitive inhibitor of p38 MAP Kina | 1MG | ₹15760 | 2022-06-14 | Buy |
Sigma-Aldrich(India) | 559395 | SB 203580, Hydrochloride - CAS 869185-85-3 - Calbiochem SB 203580, Hydrochloride, CAS 869185-85-3, is a water-soluble form of SB 203580. A highly potent, selective, ATP-competitive inhibitor of p38 MAP Kina | 10MG | ₹42220 | 2022-06-14 | Buy |
Properties
storage temp. :-20C
solubility :insoluble in EtOH; insoluble in H2O; ≥20.7 mg/mL in DMSO
form :Bright yellow solid
color :Light yellow to yellow
Water Solubility :Soluble to 25 mM in water
Stability :Hygroscopic
solubility :insoluble in EtOH; insoluble in H2O; ≥20.7 mg/mL in DMSO
form :Bright yellow solid
color :Light yellow to yellow
Water Solubility :Soluble to 25 mM in water
Stability :Hygroscopic
Safety Information
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Description
Mitogen-activated protein kinases (MAPKs) mediate signal transduction from cell surface receptors to the nucleus and are classified into various subtypes. p38 MAPK is activated by environmental stresses and inflammatory cytokines and is critical for normal immune and inflammatory responses as it regulates the expression of many cytokines, transcription factors, and cell surface receptors. p38 MAPK activity in heat-shocked HeLa cells and osmotically stressed PC12 cells is inhibited by SB 203580 with an IC50 value of 0.6 μM. SB 203580 also prevents the activation of PKB/Akt by inhibiting phosphoinositide-dependent protein kinase 1 (PDK1) at IC50 values of 3-5 μM. SB 203580 (hydrochloride) has a formulation with greater solubility in organic solvents than standard SB 203580 .More related product prices
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