Shikonin
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- ₹13100
- Product name: Shikonin
- CAS: 517-89-5
- MF: C16H16O5
- MW: 288.3
- EINECS:
- MDL Number:MFCD00075680
- Synonyms:5,8-Dihydroxy-2-[(R)-1-hydroxy-4-methyl-3-pentenyl]-1,4-naphthalenedione;Tokyo Violet;(R)-5,8-Dihydroxy-2-(1-hydroxy-4-Methylpent-3-en-1-yl)naphthalene-1,4-dione;SHIKONIN(AS);Shikonin, froM Arnebia sp.;(-)-ShikoninChina;Shikonine;Shikonin 5,8-Dihydroxy-2-[(1R)-1-hydroxy-4-methyl-pent-3-enyl]naphthalene-1,4-dione
1 prices
Selected condition：
Brand
- Sigma-Aldrich(India)
Package
- 10MG
- ManufacturerSigma-Aldrich(India)
- Product number565850
- Product descriptionShikonin - CAS 517-89-5 - Calbiochem A naphthoquinone found in the Chinese herb Shiunko.
- Packaging10MG
- Price₹13100
- Updated2022-06-14
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | 565850 | Shikonin - CAS 517-89-5 - Calbiochem A naphthoquinone found in the Chinese herb Shiunko. | 10MG | ₹13100 | 2022-06-14 | Buy |
Properties
Melting point :148℃
Boiling point :567.4±50.0 °C(Predicted)
Density :1.373±0.06 g/cm3(Predicted)
storage temp. :-20°C
solubility :DMSO : ≥ 31 mg/mL (107.53 mM);
pka :7.34±0.20(Predicted)
form :Red crystalline solid.
color :Brown
LogP :4.350 (est)
CAS DataBase Reference :517-89-5(CAS DataBase Reference)
Boiling point :567.4±50.0 °C(Predicted)
Density :1.373±0.06 g/cm3(Predicted)
storage temp. :-20°C
solubility :DMSO : ≥ 31 mg/mL (107.53 mM);
pka :7.34±0.20(Predicted)
form :Red crystalline solid.
color :Brown
LogP :4.350 (est)
CAS DataBase Reference :517-89-5(CAS DataBase Reference)
Safety Information
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Description
Shikonin is a naturally occurring naphthoquinine isolated from the dried root of L. erythrorhizon, an herb used in traditional Chinese medicine. It increases glucose uptake by adipocytes and myocytes and inhibits the activity of phosphatase and tensin homolog (PTEN; IC50 = 2.7 μM). It inhibits glycolysis in cancer cells by inhibiting tumor-specific pyruvate kinase M2 (IC50 = 0.3 μM). Shikonin induces cell death consistent with necroptosis in MCF-7 and HEK293 cancer cell lines. It inhibits leukocyte migration, downregulates chemokine receptor expression, and inhibits HIV-1 replication at nanomolar concentrations. Shikonin exhibits anti-inflammatory activity, reducing joint swelling and cartilage destruction in a mouse model of collagen-induced arthritis.Related product price
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![5,8-Dihydroxy-2-[(1R)-1-hydroxy-4-methyl-pent-3-enyl]naphthalene-1,4-dione](https://img.chemicalbook.com/ProductImageEN/2018-12/small/027035a7-de5d-4298-bea1-9acd2fce4903.png){kind=small}