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ChemicalBook > Product Catalogue >API >Hormones and the Endocrine System >Erectile Dysfunction Treatment >Sildenafil

Sildenafil

Sildenafil Structure
  • ₹10041.5
  • Product name: Sildenafil
  • CAS: 139755-83-2
  • MF: C22H30N6O4S
  • MW: 474.58
  • EINECS:604-158-7
  • MDL Number:MFCD00867528
  • Synonyms:SILDENAFIL;7H-Pyrazolo[4,3-d]pyriMidin-7-one, 5-[2-ethoxy-5-[(4-Methyl -1-piperazinyl)sulfonyl]phenyl]-1,6-dihydro-1-Methyl-3-propyl-;Sildenafil solution;5-{2-ethoxy-5-[(4-methylpiperazin-1-yl)sulfonyl]phenyl}-1-methyl-3-propyl-1,4-dihydro-7H-pyrazolo[4,3-d] pyrimidin-7-one;5-[2-Ethoxy-5-[(4-methyl-piperazin-1-yl)sulfonyl]phenyl]-1,6-dihydro-1-methyl-3-propyl-7H-pyrazolo[4,3-d]pyrimidin-7-one;5-(2-Ethoxy-5-((4-methylpiperazin-1-yl)sulfonyl)phenyl)-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one;5-[2-ethoxy-5-(4-Methylpiperazine-1-sulfonyl)phenyl]-1-Methyl-3-propyl-1H,6H,7H-pyrazolo[4,3-d]pyriMidin-7-one;1-[[3-(4,7-Dihydro-1-Methyl-7-oxo-3-propyl-1H-pyrazolo[4,3-d]pyriMidin-5-yl)-4-ethoxyphenyl]sulfonyl]-4-Methylpiperazine
Price1 Properties Safety Information Description
1 prices
Selected condition：

Brand

  • Sigma-Aldrich(India)

Package

  • 1ML
  • ManufacturerSigma-Aldrich(India)
  • Product numberS-010
  • Product descriptionSildenafil solution 1.0?mg/mL in methanol, ampule of 1?mL, certified reference material, Cerilliant?
  • Packaging1ML
  • Price₹10041.5
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) S-010 Sildenafil solution 1.0?mg/mL in methanol, ampule of 1?mL, certified reference material, Cerilliant? 1ML ₹10041.5 2022-06-14 Buy

Properties

Melting point :187-189°C
Density :1.39±0.1 g/cm3(Predicted)
Flash point :9℃
storage temp. :Sealed in dry,Store in freezer, under -20°C
solubility :DMSO (Slightly), Methanol (Slightly)
form :Solid
pka :pKa 8.7 (Uncertain)
color :White to Off-White
InChIKey :BNRNXUUZRGQAQC-UHFFFAOYSA-N
CAS DataBase Reference :139755-83-2(CAS DataBase Reference)
EPA Substance Registry System :7H-Pyrazolo[4,3-d]pyrimidin-7-one, 5-[2-ethoxy-5-[(4-methyl-1-piperazinyl)sulfonyl]phenyl]-1,6-dihydro-1-methyl-3-propyl- (139755-83-2)

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictogramsGHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H225 Highly Flammable liquid and vapour Flammable liquids Category 2 Danger GHS hazard pictograms P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501
H370 Causes damage to organs Specific target organ toxicity, single exposure Category 1 Danger GHS hazard pictograms P260, P264, P270, P307+P311, P321,P405, P501
Precautionary statements:
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P311 Call a POISON CENTER or doctor/physician.

Description

Sildenafil was launched as Viagra in the US for the treatment of organic orland psychological male erectile dysfunction (ED). It is an orally bioavailable pyrazolopyrimidinone derivative structurally related to zaprinast, with vasodilating and potential anti-inflammatory activities. Upon oral administration, sildenafil selectively targets and inhibits cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5), thereby inhibiting the PDE5-mediated degradation of cGMP found in smooth muscle and increasing cGMP availability. This results in prolonged smooth muscle relaxation in the corpus cavernosum of the penis, thereby causing vasodilation, blood engorgement and a prolonged penile erection.

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Suppliers and manufacturers

Sichuan Kulinan Technology Co., Ltd Chengdu Dianchun Technology Co., Ltd Chengdu HuaXia Chemical Reagent Co. Ltd