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Bazedoxifene

Bazedoxifene Structure
CAS No.
198481-32-2
Chemical Name:
Bazedoxifene
Synonyms
Tse-424;CS-1993;Batoxifene;Bazedoxifen;Bazedoxifene;Bazedoxifeno;Unii-Q16tt9C5bk;BAZEDOXIFENE BASE;Bazedoxifene [inn];Bazedoxifene free base
CBNumber:
CB01458163
Molecular Formula:
C30H34N2O3
Molecular Weight:
470.6
MOL File:
198481-32-2.mol
MSDS File:
SDS
Modify Date:
2023/10/31 12:04:19
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Bazedoxifene Properties

Melting point 98-102°
Boiling point 694.4±55.0 °C(Predicted)
Density 1.19
storage temp. Sealed in dry,Store in freezer, under -20°C
solubility Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
form Solid
pka 10.12±0.15(Predicted)
color White to Very Dark Beige

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS08
Signal word  Danger
Hazard statements  H360
Precautionary statements  P201-P202-P281-P308+P313-P405-P501

Bazedoxifene Chemical Properties,Uses,Production

General Description

Bazedoxifene, 1-[[4-[2-(azepan-1-yl)ethoxy]phenyl]methyl]-2-(4-hydroxyphenyl)-3-methylindol-5-ol (Viviant), was declared to be “approvable” bythe FDA in 2007 for the prevention of postmenopausalosteoporosis. As of mid-2009, final approval in the UnitedStates is still pending. Bazedoxifene was approved inEurope in 2009 for the treatment of post–menopausalosteoporosis.

Clinical Use

Bazedoxifene is an indole-based SERM that is under investigation for the treatment and prevention of postmenopausal osteoporosis. It also is being evaluated in combination with Premarin (conjugated estrogens). Bazedoxifene displaces 17β-estradiol from estrogen receptors and has excellent binding affinity for the receptor itself. Unlike raloxifene, this agent does not cause hot flashes at the doses required to have a beneficial effect on bone. In addition, it does not cause uterine or mammary gland stimulation.

Enzyme inhibitor

This potent and selective estrogen receptor modulator, or SERM (FW = 530.65 g/mol; CAS 198481-33-3; Solubility: 00 mM in DMSO), also named 1-[[4-[2- (hexahydro-1H-azepin-1-yl) ethoxy]phenyl]methyl]-2- (4- hydroxyphenyl) -3-methyl-1H-indol-5-ol, selectivity targets the extrogen receptor ERα (IC50 = 26 nM), with weaker action against ERβ (IC50 = 99 nM), inhibiting 17β-estradiol-induced proliferation of MCF-7 cells. Bazedoxifene represents a promising new treatment for osteoporosis, one with a potential for less uterine and vasomotor effects than selective estrogen receptor modulators now used clinically.

Bazedoxifene Preparation Products And Raw materials

Raw materials

1H-Indol-5-ol, 1-[[4-(2-aminoethoxy)phenyl]methyl]-2-(4-hydroxyphenyl)-3-methyl- 1H-Azepine-2,7-dione, tetrahydro-1-[2-[4-[[5-hydroxy-2-(4-hydroxyphenyl)-3-methyl-1H-indol-1-yl]methyl]phenoxy]ethyl]- 1H-Indol-5-ol, 2-[4-(acetyloxy)phenyl]-3-methyl-, 5-acetate Adipaldehyde 1-[4-(2-AZEPAN-1-YL-ETHOXY)-BENZYL]-5-BENZYLOXY-2-(4-BENZYLOXY-PHENYL)-3-METHYL-1H-INDOLE
2-(4-hydroxyphenyl)-3-Methyl-1H-indol-5-ol 4-[2-(1-AZEPANYL)ETHOXY]BENZYL CHLORIDE HCL Hexamethyleneimine
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Preparation Products

Bazedoxifene Suppliers

Global( 114)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
Viyash Life Sciences Pvt Ltd +91-4023635052 +91-4023635052 Telangana, India 213 58 Inquiry
Alembic Pharmaceuticals Limited +91-2652280880 +91-2652280550 Gujarat, India 115 58 Inquiry
Symed Laboratories Ltd +91-9505426644 +91-9505426644 Telangana, India 54 58 Inquiry
Aarti Industries Limited (AIL) +91-84596144931 +91-9920899935 Maharashtra, India 235 58 Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd +91-172-5066494 Haryana, India 6773 58 Inquiry
SynZeal Research Pvt Ltd +1 226-802-2078 Gujarat, India 6522 58 Inquiry
Chiral Biosciences Limited 09441920381 Mallapur, India 41 58 Inquiry
Pharma Affiliates 172-5066494 Haryana, India 6761 58 Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6351 58 Inquiry
Zibo Hangyu Biotechnology Development Co., Ltd +86-0533-2185556 +8617865335152 China 10978 58 Inquiry
Supplier Advantage
Viyash Life Sciences Pvt Ltd 58
Alembic Pharmaceuticals Limited 58
Symed Laboratories Ltd 58
Aarti Industries Limited (AIL) 58
Pharmaffiliates Analytics and Synthetics P. Ltd 58
SynZeal Research Pvt Ltd 58
Chiral Biosciences Limited 58
Pharma Affiliates 58
CLEARSYNTH LABS LTD. 58
Zibo Hangyu Biotechnology Development Co., Ltd 58

198481-32-2(Bazedoxifene)Related Search:

FLAVOXATE Olaparib Indacaterol CETUXIMAB Baclofen
VILAZODONE Rivaroxaban Liraglutide Capecitabine Sofosbuvir
Dapoxetine 1-[[4-[2-(Hexahydro-1-oxido-1H-azepin-1-yl)ethoxy]phenyl]Methyl]-2-(4-hydroxyphenyl)-3-Methyl-1H-indol-5-ol BAZEDOXIFENE ACETATE 4-[2-(DIMETHYLAMINO)ETHOXY]BENZYLAMINE 1-Ethyl-2-phenylindole
Bazedoxifene 1-[4-(2-AZEPAN-1-YL-ETHOXY)-BENZYL]-5-BENZYLOXY-2-(4-BENZYLOXY-PHENYL)-3-METHYL-1H-INDOLE 1,3-DIMETHYL-2-PHENYLINDOLE
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1-[[4-[2-(azepan-1-yl)ethoxy]phenyl]methyl]-2-(4-hydroxyphenyl)-3-methyl-indol-5-ol 1-((4-(2-Hexahydro-1H-azepin-1-yl)ethoxy)phenyl)methyl)-2-(4-hydroxyphenyl)-3-methyl-1H-indol-5-ol 1H-Indol-5-ol, 1-((4-(2-(hexahydro-1H-azepin-1-yl)ethoxy)phenyl)methyl)-2-(4-hydroxyphenyl)-3-methyl- Bazedoxifene Bazedoxifene [inn] Bazedoxifeno Bazedoxifeno [inn-spanish] Tse-424 Unii-Q16tt9C5bk Bazedoxifen CS-1993 Batoxifene BAZEDOXIFENE BASE Bazedoxifene free base 1-[[4-[2-(azepan-1-yl)ethoxy]phenyl]methyl]-2-(4-hydroxyphen... 1-(4-(2-(Azepan-1-yl)ethoxy)benzyl)-2-(4-hydroxyphenyl)-3-methyl-1H-indol-5-ol 198481-32-2 C30H34N2O3 Aromatics Heterocycles Intermediates & Fine Chemicals Pharmaceuticals