Mirin
- CAS No.
- 299953-00-7
- Chemical Name:
- Mirin
- Synonyms
- Mirin >=98% (HPLC), powder;MRN-ATM Pathway Inhibitor, Mirin;5-(4-Hydroxybenzylidene)-2-iminothiazolidin-4-one;(E)-5-(4-hydroxybenzylidene)-2-iminothiazolidin-4-one;4(5H)-Thiazolone, 2-amino-5-[(4-hydroxyphenyl)methylene]-;(5E)-5-(4-Hydroxybenzylidene)-2-imino-1,3-thiazolidin-4-one
- CBNumber:
- CB02501840
- Molecular Formula:
- C10H8N2O2S
- Molecular Weight:
- 220.25
- MOL File:
- 299953-00-7.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/7/14 17:38:04
| Melting point | 295-297 °C(Solv: ethanol (64-17-5)) |
|---|---|
| Boiling point | 441.6±55.0 °C(Predicted) |
| Density | 1.49±0.1 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO: >10mg/mL |
| form | Reddish orange powder |
| pka | 9.15±0.30(Predicted) |
| color | red to orange |
| Sensitive | Moisture Sensitive |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36 | |||||||||
| Safety Statements | 26 | |||||||||
| WGK Germany | 3 | |||||||||
| NFPA 704 |
|
Mirin price More Price(3)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | M9948 | Mirin ≥98% (HPLC), powder | 299953-00-7 | 5MG | ₹9006.4 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | M9948 | Mirin ≥98% (HPLC), powder | 299953-00-7 | 25MG | ₹35744.15 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 475954 | MRN-ATM Pathway Inhibitor, Mirin - CAS 299953-00-7 - Calbiochem The MRN-ATM Pathway Inhibitor, Mirin, also referenced under CAS 299953-00-7, controls the biological activity of Mre11, component of the MRN (Mre11-Ra | 299953-00-7 | 10MG | ₹9490 | 2022-06-14 | Buy |
Mirin Chemical Properties,Uses,Production
Description
Mirin is an inhibitor of the Mre11/Rad50/Nbs1 (MRN) complex, which functions as a DNA damage sensor and activates the DNA repair enzyme ataxia-telangiectasia mutated kinase (ATM). It inhibits phosphorylation of H2AX induced by DNA containing dsDNA breaks (DSBs), indicating decreased ATM activation, with an IC50 value of 66 μM in X. laevis cell-free extracts. Mirin (100 μM) also inhibits the exonuclease activity of Mre11 in a cell-free assay. It induces cell cycle arrest at the G2 phase in TOSA4 cells and inhibits homology-dependent repair in HEK293 cells in a concentration-dependent manner. Nanoparticle-encapsulated mirin (50 mg/kg) reduces tumor growth in an LA-N-5 mouse xenograft model.
Uses
The Mre11-Rad50-Nbs1 (MRN) complex acts as a DNA damage sensor, maintains genome stability during DNA replication, and activates and recruits ataxia-telangiectasia mutated (ATM) to damaged DNA. The genes that encode the MRN proteins are all essential for cell viability, so functional studies of MRN cannot involve deletion of these genes. Mirin is an inhibitor of MRN, inhibiting MRN-dependent phosphorylation of histone H2AX (IC50 = 66 μM). Through its effects on MRN, mirin prevents activation of ATM. Inhibition of MRN centers on the ability of mirin to block the nuclease activity of Mre11, rather than altering DNA-binding or MRN complex formation. In cells, mirin induces G2 arrest, abolishes the radiation-induced G2/M checkpoint, and prevents homology-directed repair of DNA damage.[Cayman Chemical]
Biochem/physiol Actions
Mirin is an inhibitor of the Mre11-Rad50-Nbs1 complex. It disrupts nuclease activity of Mre11 and thus, the ability to repair DNA double strand breaks.
Mirin Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| LEAPCHEM CO., LTD. | +86-852-30606658 | China | 43348 | 58 | Inquiry |
| Aladdin Scientific | +1-+1(833)-552-7181 | United States | 52927 | 58 | Inquiry |
| RD International Technology Co., Limited | 18024082417 | China | 9282 | 58 | Inquiry |
| Nantong QuanYi Biotechnology Co., Ltd | 0513-66337626 18051384581 | China | 4552 | 58 | Inquiry |
| Matrix Scientific | 803 788-9494 All other calls | United States | 6655 | 80 | Inquiry |
| Angel Pharmatech, Ltd. | 17317130613 | China | 3249 | 58 | Inquiry |
| Riedel-de Haen AG | 800 558-9160 | United States | 6825 | 87 | Inquiry |
| Block Chemical Technology (Shanghai) Co., LTD | 021-20432219 13918097649 | China | 9562 | 58 | Inquiry |
| Beijing Shengke Boyuan Biotechnology Co., Ltd. | 010-62968438 | CHINA | 6011 | 58 | Inquiry |
| Guangzhou Weijia Technology Co., Ltd. | 020-84224925 18300190102 | CHINA | 6748 | 58 | Inquiry |