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7-CHLORO-5-(2-CHLOROPHENYL)-1,5-DIHYDRO-4,1-BENZOTHIAZEPIN-2(3H)-ONE

7-CHLORO-5-(2-CHLOROPHENYL)-1,5-DIHYDRO-4,1-BENZOTHIAZEPIN-2(3H)-ONE Structure
CAS No.
75450-34-9
Chemical Name:
7-CHLORO-5-(2-CHLOROPHENYL)-1,5-DIHYDRO-4,1-BENZOTHIAZEPIN-2(3H)-ONE
Synonyms
CGP 37157;1-benzothiazepine-2(3H)-one;7-Chloro-5-(2-chlorophenyl)-1;CGP-37157 - CAS 75450-34-9 - Calbiochem;CGP 37157,CGP37157,Inhibitor,CGP-37157,inhibit,Na+/Ca2+ Exchanger;7-chloro-5-(2-chlorophenyl)benzo[e][1,4]thiazepin-2(1H,3H,5H)-one;7-CHLORO-5-(2-CHLOROPHENYL)-1,5-DIHYDRO-4,1-BENZOTHIAZEPIN-2(3H)-ONE;7-Chloro-5-(2-chlorophenyl)-1,5-dihydro-4,1-benzothiazepine-2(3H)-one;4,1-Benzothiazepin-2(3H)-one, 7-chloro-5-(2-chlorophenyl)-1,5-dihydro-;7-Chloro-5-(2-chlorophenyl)-3,5-dihydrobenzo[e][1,4]thiazepin-2(1H)-one
CBNumber:
CB7314153
Molecular Formula:
C15H11Cl2NOS
Molecular Weight:
324.22
MOL File:
75450-34-9.mol
MSDS File:
SDS
Modify Date:
2023/6/30 15:45:59
Request For Quotation

7-CHLORO-5-(2-CHLOROPHENYL)-1,5-DIHYDRO-4,1-BENZOTHIAZEPIN-2(3H)-ONE Properties

Boiling point 479.8±45.0 °C(Predicted)
Density 1.384±0.06 g/cm3(Predicted)
storage temp. 2-8°C
solubility DMSO: ≥20mg/mL
pka 12.20±0.40(Predicted)
form White solid
color white
Stability Stable for 2 years from date of purchase as supplied. Solution in DMSO may be stored at -20°C for up to 3 months.

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07,GHS09
Signal word  Warning
Hazard statements  H400-H302
Precautionary statements  P264-P270-P301+P312-P330-P501-P273-P391-P501
Hazard Codes  Xn,N
Risk Statements  22-50
Safety Statements  61
WGK Germany  3
NFPA 704
0
2 0

7-CHLORO-5-(2-CHLOROPHENYL)-1,5-DIHYDRO-4,1-BENZOTHIAZEPIN-2(3H)-ONE price More Price(3)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) C8874 CGP-37157 ≥98% (HPLC), powder 75450-34-9 5MG ₹15674.6 2022-06-14 Buy
Sigma-Aldrich(India) C8874 CGP-37157 ≥98% (HPLC), powder 75450-34-9 25MG ₹63033.98 2022-06-14 Buy
Sigma-Aldrich(India) 220005 CGP-37157 - CAS 75450-34-9 - Calbiochem A cell-permeable benzothiazepine derivative of clonazepam that acts as a specific and potent inhibitor of the mitochondrial Na+/Ca2+ exchanger (IC?? = 75450-34-9 5MG ₹23839.99 2022-06-14 Buy
Product number Packaging Price Buy
C8874 5MG ₹15674.6 Buy
C8874 25MG ₹63033.98 Buy
220005 5MG ₹23839.99 Buy

7-CHLORO-5-(2-CHLOROPHENYL)-1,5-DIHYDRO-4,1-BENZOTHIAZEPIN-2(3H)-ONE Chemical Properties,Uses,Production

Uses

7-Chloro-5-(2-chlorophenyl)-1,5-dihydro-4,1-benzothiazepin-2(3H)-one is a specific inhibitor of the mitochondrial Na+/Ca2+ exchanger.

General Description

CGP-37157 is a benzothiazepine compound, which is derived from clonazepam. It functions as a sarco/endoplasmic reticulum Ca2+ ATPase (SERCA) antagonist and ryanodine receptor channels (RyR) agonist. CGP-37157 regulates intracellular signaling of calcium in smooth, cardiac and skeletal muscle cells and non-muscle systems.

Biological Activity

Selective antagonist of the mitochondrial Na + -Ca 2+ exchanger (IC 50 = 0.4 μ M).

7-CHLORO-5-(2-CHLOROPHENYL)-1,5-DIHYDRO-4,1-BENZOTHIAZEPIN-2(3H)-ONE Preparation Products And Raw materials

Raw materials

Preparation Products

7-CHLORO-5-(2-CHLOROPHENYL)-1,5-DIHYDRO-4,1-BENZOTHIAZEPIN-2(3H)-ONE Suppliers

Global( 77)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6351 58 Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 +1-00000000000 United States 19892 58 Inquiry
Aromsyn Co., Ltd. +86-0571-85585865 +8613336024896 China 19185 58 Inquiry
LEAPCHEM CO., LTD. +86-852-30606658 China 43348 58 Inquiry
Jilin Chinese Academy of Sciences-yanshen Technology +undefined18143011203 China 42057 58 Inquiry
Aladdin Scientific +1-+1(833)-552-7181 United States 57511 58 Inquiry
Shanghai Aladdin Biochemical Technology Co.,Ltd. +86-18521732826 China 48467 58 Inquiry
Wuhan Topule +86-02787215551 +86-19945035818 China 8213 58 Inquiry
Suzhou Zhixin Biotechnology Co., Ltd. 0512-65118909 15162312715 China 2992 58 Inquiry
Hubei Kele Fine Chemical Co., Ltd 027-59101668 19945030958 China 7984 58 Inquiry
Supplier Advantage
CLEARSYNTH LABS LTD. 58
TargetMol Chemicals Inc. 58
Aromsyn Co., Ltd. 58
LEAPCHEM CO., LTD. 58
Jilin Chinese Academy of Sciences-yanshen Technology 58
Aladdin Scientific 58
Shanghai Aladdin Biochemical Technology Co.,Ltd. 58
Wuhan Topule 58
Suzhou Zhixin Biotechnology Co., Ltd. 58
Hubei Kele Fine Chemical Co., Ltd 58

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7-CHLORO-5-(2-CHLOROPHENYL)-1,5-DIHYDRO-4,1-BENZOTHIAZEPIN-2(3H)-ONE CGP 37157 7-Chloro-5-(2-chlorophenyl)-1,5-dihydro-4,1-benzothiazepine-2(3H)-one 4,1-Benzothiazepin-2(3H)-one, 7-chloro-5-(2-chlorophenyl)-1,5-dihydro- 7-chloro-5-(2-chlorophenyl)benzo[e][1,4]thiazepin-2(1H,3H,5H)-one CGP-37157 - CAS 75450-34-9 - Calbiochem 1-benzothiazepine-2(3H)-one 7-Chloro-5-(2-chlorophenyl)-1 7-Chloro-5-(2-chlorophenyl)-3,5-dihydrobenzo[e][1,4]thiazepin-2(1H)-one CGP 37157,CGP37157,Inhibitor,CGP-37157,inhibit,Na+/Ca2+ Exchanger 75450-34-9 C15H12ClNOS Ion transporter and other ion channel Signalling