ChemicalBook > Product Catalog >Biochemical Engineering >Inhibitors >Cytoskeletal Signaling >Dynamin inhibitors >3-(2,4-Dichloro-5-methoxyphenyl)-2,3-dihydro-2-thioxo-4(1H)-quinazolinone

3-(2,4-Dichloro-5-methoxyphenyl)-2,3-dihydro-2-thioxo-4(1H)-quinazolinone

CAS No.: 338967-87-6

Chemical Name:: 3-(2,4-Dichloro-5-methoxyphenyl)-2,3-dihydro-2-thioxo-4(1H)-quinazolinone

Synonyms: Mdivi 1;4(1H)-Quinazolinone, 3-(2,4-dichloro-5-methoxyphenyl)-2,3-dihydro-2-thioxo-;Mdivi;CS-951;Mdivi1/Mdivi-1;Mdivi-1, 338967-87-6;Mitochondrial division inhibitor 1;Mitochondrial Division Inhibitor, mdivi-1;Mdivi-1 (Mitochondrial division inhibitor 1);MDIVI 1;MDIVI1;MITOCHONDRIAL DIVISION INHIBITOR 1

CBNumber:: CB92518885

Molecular Formula:: C15H10Cl2N2O2S

Molecular Weight:: 353.22

MOL File:: 338967-87-6.mol

MSDS File:: SDS

Modify Date:: 2024/4/24 17:21:45

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3-(2,4-Dichloro-5-methoxyphenyl)-2,3-dihydro-2-thioxo-4(1H)-quinazolinone Properties

Melting point	289 °C
Boiling point	522.5±60.0 °C(Predicted)
Density	1.57±0.1 g/cm3(Predicted)
storage temp.	-20°C
solubility	DMSO: >20mg/mL
form	White solid
pka	9.91±0.20(Predicted)
color	White
Stability	Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P305+P351+P338
WGK Germany	3
HS Code	2933.59.8000

3-(2,4-Dichloro-5-methoxyphenyl)-2,3-dihydro-2-thioxo-4(1H)-quinazolinone price More Price(5)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich(India)	M0199	Mdivi-1 ≥98% (HPLC), powder	338967-87-6	5MG	₹7198.63	2022-06-14	Buy
Sigma-Aldrich(India)	M0199	Mdivi-1 ≥98% (HPLC), powder	338967-87-6	25MG	₹28632.13	2022-06-14	Buy
Sigma-Aldrich(India)	475856	Mitochondrial Division Inhibitor, mdivi-1 - CAS 338967-87-6 - Calbiochem The Mitochondrial Division Inhibitor, mdivi-1, also referenced under CAS 338967-87-6, controls the biological activity of yeast Dnm1 and mammalian Drp	338967-87-6	10MG	₹16610	2022-06-14	Buy
TCI Chemicals (India)	M3108	Mdivi-1	338967-87-6	10MG	₹7200	2022-05-26	Buy
TCI Chemicals (India)	M3108	Mdivi-1	338967-87-6	50MG	₹14800	2022-05-26	Buy

Product number	Packaging	Price	Buy
M0199	5MG	₹7198.63	Buy
M0199	25MG	₹28632.13	Buy
475856	10MG	₹16610	Buy
M3108	10MG	₹7200	Buy
M3108	50MG	₹14800	Buy

3-(2,4-Dichloro-5-methoxyphenyl)-2,3-dihydro-2-thioxo-4(1H)-quinazolinone Chemical Properties,Uses,Production

Description

Mdivi 1 is a mitochondrial division inhibitor. It inhibits the GTPase activity of yeast, but not human, dynamin-1 (Dnm1; IC₅₀ = ~1-10 μM for the recombinant yeast enzyme) and human dynamin-related protein 1 (DRP1) in A549 lung cancer cells when used at a concentration of 50 μM. Mdivi 1 (50 μM) inhibits mitochondrial fragmentation and DRP1 self-assembly induced by staurosporine in COS cells overexpressing DRP1. It induces apoptosis in, and inhibits colony formation of, A549 cells when used at concentrations of 25 and 50 μM, respectively. Mdivi 1 (1 μM) decreases doxorubicin-induced increases in infarct-to-risk ratios in a Langendorff isolated perfused rat heart model of ischemia-reperfusion injury. It reduces the severity of lung injury in a mouse model of LPS-induced acute lung injury when administered at a dose of 20 mg/kg.

Uses

Mdivi-1 is an inhibitor of mitochondrial division DRP1 and Dynamin I.

General Description

Mitochondrial Division Inhibitor 1 (Mdivi-1) is a quinazolinone derivative and is cell permeable. It traverses blood-brain barrier and elicits protective functionality in heart and brain ischemia-reperfusion injury.

3-(2,4-Dichloro-5-methoxyphenyl)-2,3-dihydro-2-thioxo-4(1H)-quinazolinone Preparation Products And Raw materials

Raw materials

Preparation Products

3-(2,4-Dichloro-5-methoxyphenyl)-2,3-dihydro-2-thioxo-4(1H)-quinazolinone Suppliers

Global( 140)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
A.J Chemicals	91-9810153283	New Delhi, India	6124	58	Inquiry
TCI Chemicals (India) Pvt. Ltd.	1800 425 7889	New Delhi, India	6778	58	Inquiry
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	China	20366	58	Inquiry
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	China	32760	60	Inquiry
career henan chemical co	+86-0371-86658258 +8613203830695	China	29901	58	Inquiry
Shenzhen Nexconn Pharmatechs Ltd	+86-755-89396905 +86-15013857715	China	10259	58	Inquiry
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	United States	19892	58	Inquiry
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	China	26368	58	Inquiry
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	China	10522	58	Inquiry
InvivoChem	+1-708-310-1919 +1-13798911105	United States	6393	58	Inquiry

Supplier	Advantage
A.J Chemicals	58
TCI Chemicals (India) Pvt. Ltd.	58
Henan Fengda Chemical Co., Ltd	58
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Shenzhen Nexconn Pharmatechs Ltd	58
TargetMol Chemicals Inc.	58
Dideu Industries Group Limited	58
Zhejiang J&C Biological Technology Co.,Limited	58
InvivoChem	58

3-(2,4-Dichloro-5-methoxyphenyl)-2,3-dihydro-2-thioxo-4(1H)-quinazolinone Spectrum

3-(2,4-Dichloro-5-methoxyphenyl)-2,3-dihydro-2-thioxo-4(1H)-quinazolinone(338967-87-6)¹HNMR

338967-87-6(3-(2,4-Dichloro-5-methoxyphenyl)-2,3-dihydro-2-thioxo-4(1H)-quinazolinone)Related Search:

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3-(2,4-Dichloro-5-methoxyphenyl)-2,3-dihydro-2-thioxo-4(1H)-quinazolinone Mdivi1/Mdivi-1 Mitochondrial division inhibitor 1 3-(2,4-DICHLORO-5-METHOXYPHENYL)-2-THIOXO-2,3-DIHYDROQUINAZOLIN-4(1H)-ONE EXACT Mitochondrial Division Inhibitor, mdivi-1 3-(2,4-Dichloro-5-methoxyphenyl)-2,3-dihydro-2-thioxo-4(1H)-quinazolinone Mdivi-1 Mitochondrial division inhibitor 1 3-(2,4-Dichloro-5-methoxyphenyl)-2,3-dihydro-2-thioxo-4(1H)-quinazolinone Mdivi-1, 338967-87-6 Mitochondrial Division Inhibitor, mdivi-1 - CAS 338967-87-6 - Calbiochem CS-951 MDIVI 1;MDIVI1;MITOCHONDRIAL DIVISION INHIBITOR 1 3-(2,4-Dichloro-5-methoxyphenyl)-2-thioxo-2,3-dihydro-4(1H)-quinazolinone 3-(2,4-Dichloro-5-methoxyphenyl)-2,3-dihydro-2-thioxo-4(1H)-quinazolinone USP/EP/BP Mdivi-1 (Mitochondrial division inhibitor 1) Mdivi Mdivi 1 4(1H)-Quinazolinone, 3-(2,4-dichloro-5-methoxyphenyl)-2,3-dihydro-2-thioxo- 3-(2,4-Dichloro-5-methoxyphenyl)-2-mercaptoquinazolin-4(3H)-one Mitochondrial Autophagy,Mitochondrial division inhibitor1,Inhibitor,inhibit,Autophagy,Mitophagy,Mdivi 1,Mdivi1,Mitochondrial division inhibitor-1,Dynamin,Apoptosis,Mdivi-1 338967-87-6 C25H10Cl2N2O2S Inhibitors