3-(2,4-Dichloro-5-methoxyphenyl)-2,3-dihydro-2-thioxo-4(1H)-quinazolinone
|
- ₹7198.63 - ₹28632.13
- Product name: 3-(2,4-Dichloro-5-methoxyphenyl)-2,3-dihydro-2-thioxo-4(1H)-quinazolinone
- CAS: 338967-87-6
- MF: C15H10Cl2N2O2S
- MW: 353.22
- EINECS:
- MDL Number:MFCD00974506
- Synonyms:3-(2,4-Dichloro-5-methoxyphenyl)-2,3-dihydro-2-thioxo-4(1H)-quinazolinone;Mdivi1/Mdivi-1;Mitochondrial division inhibitor 1;3-(2,4-DICHLORO-5-METHOXYPHENYL)-2-THIOXO-2,3-DIHYDROQUINAZOLIN-4(1H)-ONE EXACT;Mitochondrial Division Inhibitor, mdivi-1 ;3-(2,4-Dichloro-5-methoxyphenyl)-2,3-dihydro-2-thioxo-4(1H)-quinazolinone Mdivi-1;Mitochondrial division inhibitor 1 3-(2,4-Dichloro-5-methoxyphenyl)-2,3-dihydro-2-thioxo-4(1H)-quinazolinone;Mdivi-1, 338967-87-6
5 prices
Selected condition：
Brand
- TCI Chemicals (India)
- Sigma-Aldrich(India)
Package
- 5MG
- 10MG
- 25MG
- 50MG
- ManufacturerTCI Chemicals (India)
- Product numberM3108
- Product descriptionMdivi-1
- Packaging10MG
- Price₹7200
- Updated2022-05-26
- Buy
- ManufacturerTCI Chemicals (India)
- Product numberM3108
- Product descriptionMdivi-1
- Packaging50MG
- Price₹14800
- Updated2022-05-26
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberM0199
- Product descriptionMdivi-1 ≥98% (HPLC), powder
- Packaging5MG
- Price₹7198.63
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product number475856
- Product descriptionMitochondrial Division Inhibitor, mdivi-1 - CAS 338967-87-6 - Calbiochem The Mitochondrial Division Inhibitor, mdivi-1, also referenced under CAS 338967-87-6, controls the biological activity of yeast Dnm1 and mammalian Drp
- Packaging10MG
- Price₹16610
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberM0199
- Product descriptionMdivi-1 ≥98% (HPLC), powder
- Packaging25MG
- Price₹28632.13
- Updated2022-06-14
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| TCI Chemicals (India) | M3108 | Mdivi-1 | 10MG | ₹7200 | 2022-05-26 | Buy |
| TCI Chemicals (India) | M3108 | Mdivi-1 | 50MG | ₹14800 | 2022-05-26 | Buy |
| Sigma-Aldrich(India) | M0199 | Mdivi-1 ≥98% (HPLC), powder | 5MG | ₹7198.63 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 475856 | Mitochondrial Division Inhibitor, mdivi-1 - CAS 338967-87-6 - Calbiochem The Mitochondrial Division Inhibitor, mdivi-1, also referenced under CAS 338967-87-6, controls the biological activity of yeast Dnm1 and mammalian Drp | 10MG | ₹16610 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | M0199 | Mdivi-1 ≥98% (HPLC), powder | 25MG | ₹28632.13 | 2022-06-14 | Buy |
Properties
Melting point :289 °C
Boiling point :522.5±60.0 °C(Predicted)
Density :1.57±0.1 g/cm3(Predicted)
storage temp. :-20°C
solubility :DMSO: >20mg/mL
form :White solid
pka :9.91±0.20(Predicted)
color :White
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Boiling point :522.5±60.0 °C(Predicted)
Density :1.57±0.1 g/cm3(Predicted)
storage temp. :-20°C
solubility :DMSO: >20mg/mL
form :White solid
pka :9.91±0.20(Predicted)
color :White
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Safety Information
| Symbol(GHS): |
|
|||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal word: | Warning | |||||||||||||||||||||||||||||||||||
| Hazard statements: |
|
|||||||||||||||||||||||||||||||||||
| Precautionary statements: |
|
Description
Mitochondrial fusion and division proteins function via self assembly to regulate membrane dynamics during various cellular events. For example, the self assembly of dynamin-1, a mitochondrial protein that facilitates endocytosis, with a dynamin related-GTPase (Dnm1 (yeast)/Drp1(mammals)), a mitochondrial protein that functions during mitochondrial division, is thought to regulate apoptosis. Mdivi 1 is a quinazolinone derivative that selectively inhibits mitochondrial division by blocking dynamin GTPase activity in yeast (IC50 = 1-10 μM) and mammalian cells (IC50 = ~50 μM). It has been shown to prevent apoptosis by inhibiting mitochondrial outer membrane permeabilization in vivo and to block Bid-activated Bax/Bak-dependent cytochrome c release from mitochondria in vitro. It has been used to maintain mitochondrial integrity and to prevent cell death in models of pathological conditions including cancer, heart failure, and ischemia and reperfusion injuries.Suppliers and manufacturers
Henan Fengda Chemical Co., Ltd
₹2.00 /1000kg
3-(2,4-Dichloro-5-methoxyphenyl)-2,3-dihydro-2-thioxo-4(1H)-quinazolinone CAS:338967-87-6
3-(2,4-Dichloro-5-methoxyphenyl)-2,3-dihydro-2-thioxo-4(1H)-quinazolinone CAS:338967-87-6
career henan chemical co
A.J Chemicals
TCI Chemicals (India) Pvt. Ltd.
ATK CHEMICAL COMPANY LIMITED
Shenzhen Nexconn Pharmatechs Ltd
TargetMol Chemicals Inc.
Dideu Industries Group Limited
Zhejiang J&C Biological Technology Co.,Limited
InvivoChem
₹1.00 /1KG
3-(2,4-Dichloro-5-methoxyphenyl)-2,3-dihydro-2-thioxo-4(1H)-quinazolinone CAS:338967-87-6
3-(2,4-Dichloro-5-methoxyphenyl)-2,3-dihydro-2-thioxo-4(1H)-quinazolinone CAS:338967-87-6