N4-(9-Ethyl-9H-carbazol-3-yl)-N2-(3-Morpholin-4-yl-propyl)-pyriMidine-2,4-diaMine
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- ₹10727.58 - ₹43830.43
- Product name: N4-(9-Ethyl-9H-carbazol-3-yl)-N2-(3-Morpholin-4-yl-propyl)-pyriMidine-2,4-diaMine
- CAS: 1380432-32-5
- MF: C25H30N6O
- MW: 430.55
- EINECS:-0
- MDL Number:MFCD23143628
- Synonyms:EHop-016;EHOP-016;N4-(9-ETHYL-9H-CARBAZOL-3-YL)-N2-(3-MORPHOLIN-4-YL-PROPYL)-PYRIMIDINE-2,4-DIAMINE;N4-(9-Ethyl-9H-carbazol-3-yl)-N2-(3-Morpholin-4-yl-propyl)-pyriMidine-2,4-diaMine;N4-(9-Ethyl-9H-carbazol-3-yl)-N2-[3-(4-morpholinyl)propyl]-2,4-pyrimidinediamine;N4-(9-Ethyl-9H-carbazol-3-yl)-N2-[3-(4-morpholinyl)propyl]-2,4-pyrimidinediamine Ehop-016;EHop-016, >=98%;EHOP016; EHOP-016; EHOP 016; EHOP016; EHOP-016; EHOP 016.;EHOP 016;EHOP016
2 prices
Selected condition：
Brand
- Sigma-Aldrich(India)
Package
- 5MG
- 25MG
- ManufacturerSigma-Aldrich(India)
- Product numberSML0526
- Product descriptionEHop-016 ≥98% (HPLC)
- Packaging5MG
- Price₹10727.58
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberSML0526
- Product descriptionEHop-016 ≥98% (HPLC)
- Packaging25MG
- Price₹43830.43
- Updated2022-06-14
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | SML0526 | EHop-016 ≥98% (HPLC) | 5MG | ₹10727.58 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | SML0526 | EHop-016 ≥98% (HPLC) | 25MG | ₹43830.43 | 2022-06-14 | Buy |
Properties
Boiling point :633.9±65.0 °C(Predicted)
Density :1.27
storage temp. :2-8°C
solubility :DMSO: soluble10mg/mL, clear
pka :7.30±0.10(Predicted)
form :powder
color :white to beige
Density :1.27
storage temp. :2-8°C
solubility :DMSO: soluble10mg/mL, clear
pka :7.30±0.10(Predicted)
form :powder
color :white to beige
Safety Information
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Description
EHop-016 is an inhibitor of the small Rho GTPases Rac1 and Rac3. It inhibits Rac1 activity in MDA-MB-435 breast cancer cells with an IC50 value of 1.1 μM in a Rac1 activation assay. At a concentration of 1 μM, EHop-016 inhibits 58% of Rac3 activity, and it inhibits Cdc42 activity but only at higher concentrations (5-10 μM). It also increases Rho GTPase RhoA activity ~1.3-fold at concentrations greater than 2 μM. EHop-016 (2-4 μM) inhibits Rac-regulated functions in MDA-MB-435 cells, including lamellipodia formation and serine/threonine p21-activated kinase 1 (PAK1)-mediated cell migration. In a nude mouse model of breast cancer metastasis, EHop-016 (25 mg/kg) significantly lowers mammary fat pad tumor growth, metastasis, and angiogenesis. It also inhibits mutant receptor tyrosine kinase (KIT)-induced growth in systemic mastocytosis and acute myeloid leukemia (AML) cells (≥2.5 μM).More related product prices
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Suppliers and manufacturers
career henan chemical co
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₹1.00 /1KG
4-N-(9-ethylcarbazol-3-yl)-2-N-(3-morpholin-4-ylpropyl)pyrimidine-2,4-diamine CAS:1380432-32-5
4-N-(9-ethylcarbazol-3-yl)-2-N-(3-morpholin-4-ylpropyl)pyrimidine-2,4-diamine CAS:1380432-32-5