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ChemicalBook > Product Catalogue >Biochemical Engineering >Inhibitors >Cell Cycle >Rho inhibitor >NSC 23766 (hydrochloride)

NSC 23766 (hydrochloride)

NSC 23766 (hydrochloride) Structure
  • ₹14152.5 - ₹56898.6
  • Product name: NSC 23766 (hydrochloride)
  • CAS: 1177865-17-6
  • MF: C24H35N7
  • MW: 421.5816
  • EINECS:
  • MDL Number:MFCD08703096
  • Synonyms:NSC 23766 (hydrochloride);NSC 23766 (trihydrochloride);NSC23766 trihydrochloride;NSC-23766 trihydrochloride;N6-[2-(4-Diethylamino-1-methyl-butylamino)-6-methyl-pyrimidin-4-yl]-2-methyl-quinoline-4,6-diamine trihydrochloride;NSC-23766 HCl;NSC 23766, >=98%;Rac1 Inhibitor
Price4 Properties Safety Information Description
4 prices
Selected condition：

Brand

  • Sigma-Aldrich(India)

Package

  • 5MG
  • 10MG
  • 25MG
  • ManufacturerSigma-Aldrich(India)
  • Product numberSML0952
  • Product descriptionNSC23766 trihydrochloride ≥97% (HPLC)
  • Packaging5MG
  • Price₹14152.5
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product number553502
  • Product descriptionRac1 Inhibitor - CAS 1177865-17-6 - Calbiochem Rac1 Inhibitor, CAS 1177865-17-6, is a cell-permeable, reversible inhibitor of Rac1 GDP/GTP exchange. Interferes with the interaction between Rac1 and
  • Packaging5MG
  • Price₹35820.01
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product number553502
  • Product descriptionRac1 Inhibitor - CAS 1177865-17-6 - Calbiochem Rac1 Inhibitor, CAS 1177865-17-6, is a cell-permeable, reversible inhibitor of Rac1 GDP/GTP exchange. Interferes with the interaction between Rac1 and
  • Packaging10MG
  • Price₹44200.01
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberSML0952
  • Product descriptionNSC23766 trihydrochloride ≥97% (HPLC)
  • Packaging25MG
  • Price₹56898.6
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) SML0952 NSC23766 trihydrochloride ≥97% (HPLC) 5MG ₹14152.5 2022-06-14 Buy
Sigma-Aldrich(India) 553502 Rac1 Inhibitor - CAS 1177865-17-6 - Calbiochem Rac1 Inhibitor, CAS 1177865-17-6, is a cell-permeable, reversible inhibitor of Rac1 GDP/GTP exchange. Interferes with the interaction between Rac1 and 5MG ₹35820.01 2022-06-14 Buy
Sigma-Aldrich(India) 553502 Rac1 Inhibitor - CAS 1177865-17-6 - Calbiochem Rac1 Inhibitor, CAS 1177865-17-6, is a cell-permeable, reversible inhibitor of Rac1 GDP/GTP exchange. Interferes with the interaction between Rac1 and 10MG ₹44200.01 2022-06-14 Buy
Sigma-Aldrich(India) SML0952 NSC23766 trihydrochloride ≥97% (HPLC) 25MG ₹56898.6 2022-06-14 Buy

Properties

Melting point :>225°C (dec.)
storage temp. :-20°C
solubility :H2O: soluble10mg/mL, clear
form :powder
color :white to beige

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
Precautionary statements:
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313 IF SKIN irritation occurs: Get medical advice/attention.
P337+P313 IF eye irritation persists: Get medical advice/attention.

Description

Rac1 is a GTPase that is involved in the regulation of the cell cycle, cell-cell adhesion, motility, and differentiation. Rac1 is activated by its interaction with specific guanine nucleotide exchange factors (GEFs). NSC 23766 is a cell-permeable, reversible inhibitor of Rac1 activation by the Rac-specific GEFs TrioN and Tiam 1 (IC50 = 50 μM). It has no effect on the closely related GTPases, Cdc42 and RhoA. NSC23766 has been used to investigate the role of Rac1 in such diverse cellular functions as stem cell mobilization, epithelial cell migration, angiogenesis, leukemia cell migration and growth, and gene expression.

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