BONGKREKIC ACID
- CAS No.
- 11076-19-0
- Chemical Name:
- BONGKREKIC ACID
- Synonyms
- edioicacid;bongkrekicaci;BONGKREKIC ACID;bongkrekic acid solution;Bongkrekic Acid (AS SOLUTION);(r-(r*,s*(e,z,z,e,e,z,e)))--trimethyl;Bongkrekic Acid Solution (1.0mg/mL in 0.01 M Tris buffer, pH 7.5);3-carboxymethyl-17-methoxy-6,18,21-trimethyldocosa-2,4,8,12,14,18,20-heptaen;2,4,8,10,14,18,20-docosaheptaenedioicacid,20-(carboxymethyl)-6-methoxy-2,5,17;(2E,4Z,6R,8Z,10E,14E,17S,18Z,20E)-20-Carboxymethyl-6-methoxy-2,5,17-trimethyldocosa-2,4,8,10,14,18,20-heptaenedioic acid
- CBNumber:
- CB4140241
- Molecular Formula:
- C28H38O7
- Molecular Weight:
- 486.6
- MOL File:
- 11076-19-0.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/7/2 8:55:07
| Melting point | 50-60° |
|---|---|
| alpha | D25 +162.5° |
| Boiling point | 715.1±60.0 °C(Predicted) |
| Density | 1.114±0.06 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | Soluble in DMSO (up to 100 mg/ml) or in Water (up to 1 mg/ml). |
| form | Lyophilized solid |
| pka | 4.15±0.10(Predicted) |
| color | Colorless to light yellow |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 3 months. |
BONGKREKIC ACID Chemical Properties,Uses,Production
Uses
Bongkrekic acid solution has been used as an adenine nucleotide translocator (ANT) inhibitor to find out a different approach for the inhibition of oxidative phosphorylation in intact T98G cells. It has also been used as an inhibitor of the permeabilization transition pore complex (PTPC) pore and a tool to explore the role of PTPC in induction of apoptosis.
Definition
ChEBI: A tricarboxylic acid that is docosa-2,4,8,10,14,18,20-heptaenedioic acid substituted at positions 2 ,5 and 17 by methyl groups, at positions 6 by a methoxy group and at position 20 by a carboxymethyl group.
Enzyme inhibitor
This toxic tricarboxylic acid (FWfree-acid = 486.61 g/mol; CAS 11076-19-0), produced Pseudomonas cocovenenans, is a potent competitive inhibitor of the mitochondrial ATP-ADP translocator, effectively blocking nucleotide binding to the carrier. The name is derived from bongkrek, a moldy coconut product produced in Indonesia. The toxin accumulates when P. cocovenenans outgrows the mold. Klingenberg et al. investigated bongkrekate binding to mitochondrial membrane to examine the reorienting site mechanism. The inferred mode of inhibition requires bongkrekate to bind to the single carrier site only from the inner face of the mitochondrial membrane (i.e., the matrix side)). They confirmed the pH-dependent accumulation of [3H]bongkrekate inside the mitochondria which superimposes onto the binding at carrier sites. By breaking the membrane with Lubrol or sonication, binding to the carrier sites could be titrated, and a Kd value of approximately 5 x 10–8 M was determined. The presence of ADP or ATP increases the amount of binding but does not alter the Kd. [35S]Atractylate is displaced by [3H]bongkrekate at a 1:1 molar ratio; this displacement is dependent on ADP concentration with the Km = 0.5 x 10–6 M. See also Atractyloside The isomer known as isobongkrekic acid, which has a cis-double bond at the dicarboxylic acid end of the molecule, has similar biological activity. Target(s): Adenine nucleotide translocator, ADP/ATP carrier; ATPase; bromelain, stem; papain; ficain, or ficin.
BONGKREKIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
BONGKREKIC ACID Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | China | 32836 | 60 | Inquiry |
| BOC Sciences | 16314854226; +16314854226 | United States | 19743 | 58 | Inquiry |
| Aladdin Scientific | +1-+1(833)-552-7181 | United States | 52927 | 58 | Inquiry |
| Hebei Weibang Biotechnology Co., Ltd | +8615350571055 | China | 5848 | 58 | Inquiry |
| Suzhou Zhixin Biotechnology Co., Ltd. | 0512-65118909 15162312715 | China | 2997 | 58 | Inquiry |
| ShangHai Anpel Co, Ltd. | 18501792038; 18501792038 | China | 9614 | 58 | Inquiry |
| Nantong Hanfang Biotechnology Co. , Ltd. | 18616537568 | China | 30968 | 58 | Inquiry |
| Qingdao IniKem BioPharmaTech Co.,Ltd | 0532-58268780 | China | 279 | 55 | Inquiry |
| yimo organism | 15915870272 | China | 459 | 58 | Inquiry |