TH588
- CAS No.
- 1609960-31-7
- Chemical Name:
- TH588
- Synonyms
- TH588;CS-1701;TH588, >98%;TH588(TH-588);TH 588;TH-588;TH588;N4-cyclopropyl-6-(2,3-dic;6-(2,3-dichlorophenyl)-N4-cyclopropylpyrimidine-2,4-diamine;N4-cyclopropyl-6-(2,3-dichlorophenyl)pyrimidine-2,4-diamine;N4-Cyclopropyl-6-(2,3-dichlorophenyl)-2,4-pyrimidinediamine;2,4-Pyrimidinediamine, N4-cyclopropyl-6-(2,3-dichlorophenyl)-
- CBNumber:
- CB02741567
- Molecular Formula:
- C13H12Cl2N4
- Molecular Weight:
- 295.17
- MOL File:
- 1609960-31-7.mol
- Modify Date:
- 2023/6/30 15:45:59
| Boiling point | 545.7±60.0 °C(Predicted) |
|---|---|
| Density | 1.505±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | Soluble in DMSO (up to 5 mg/ml). |
| form | powder |
| pka | 5.90±0.10(Predicted) |
| color | white to light brown |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280-P301+P312-P302+P352-P305+P351+P338 | |||||||||
| WGK Germany | 3 | |||||||||
| NFPA 704 |
|
TH588 price More Price(2)
TH588 Chemical Properties,Uses,Production
Uses
TH 588 acts as a novel potent and selective permeable inhibitor of the nudix hydrolase MTH1 protein. It acts as a good tool to show the non-oncogene addiction concept to anti-cancer treatments.
Biochem/physiol Actions
TH588 is a potent inhibitor of human 7,8-Dihydro-8-oxoguaninetriphosphatase MTH1 (NUDT1) with an IC50 value of 5 nM and good metabolic stability. MTH1 hydrolyzes oxidized purine nucleoside triphosphates that might otherwise be incorporated into DNA/RNA and contribute to DNA damage. MTH1 removal of oxidized nucleotides that result from increased levels of reactive oxygen species (ROS) in fast-proliferating cancer cells helps protect cancer cells from proliferative stress and prevent cancer cell death. TH588 is considered a new target for cancer therapy. TH588 is highly selective towards MTH1, with no relevant inhibition of other members of the nudix protein family or a panel of 87 enzymes, GPCRs, kinases, ion channels and transporter. TH588 has been shown to selectively kill a variety of cancer cell lines and with in vivo activity shown for TH588 in SW480 colorectal and MCF7 breast tumour xenografts.
TH588 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | China | 32760 | 60 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29897 | 58 | Inquiry |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | United States | 19892 | 58 | Inquiry |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | China | 10522 | 58 | Inquiry |
| InvivoChem | +1-708-310-1919 +1-13798911105 | United States | 6393 | 58 | Inquiry |
| Coresyn Pharmatech Co., Ltd. | +86-571-86626709 +86-18157142896 | China | 9991 | 58 | Inquiry |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | China | 11681 | 58 | Inquiry |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | China | 8474 | 58 | Inquiry |
| Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd | +86-18341751992 +86-15382112998 | China | 892 | 58 | Inquiry |