TH588
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- ₹14929.5 - ₹60106.5
- Product name: TH588
- CAS: 1609960-31-7
- MF: C13H12Cl2N4
- MW: 295.17
- EINECS:
- MDL Number:MFCD28963908
- Synonyms:N4-Cyclopropyl-6-(2,3-dichlorophenyl)-2,4-pyrimidinediamine;TH588;N4-cyclopropyl-6-(2,3-dichlorophenyl)pyrimidine-2,4-diamine;TH588(TH-588);6-(2,3-dichlorophenyl)-N4-cyclopropylpyrimidine-2,4-diamine;TH 588;TH-588;TH588;CS-1701;TH588, >98%
2 prices
Selected condition：
Brand
- Sigma-Aldrich(India)
Package
- 5MG
- 25MG
- ManufacturerSigma-Aldrich(India)
- Product numberSML1096
- Product descriptionTH588 hydrochloride ≥98% (HPLC)
- Packaging5MG
- Price₹14929.5
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberSML1096
- Product descriptionTH588 hydrochloride ≥98% (HPLC)
- Packaging25MG
- Price₹60106.5
- Updated2022-06-14
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | SML1096 | TH588 hydrochloride ≥98% (HPLC) | 5MG | ₹14929.5 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | SML1096 | TH588 hydrochloride ≥98% (HPLC) | 25MG | ₹60106.5 | 2022-06-14 | Buy |
Properties
Boiling point :545.7±60.0 °C(Predicted)
Density :1.505±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :Soluble in DMSO (up to 5 mg/ml).
form :powder
pka :5.90±0.10(Predicted)
color :white to light brown
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Density :1.505±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :Soluble in DMSO (up to 5 mg/ml).
form :powder
pka :5.90±0.10(Predicted)
color :white to light brown
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Safety Information
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Description
TH588 (1609960-31-7) is a first-in-class nudix hydrolase family inhibitor.1?MTH1/NUDT1 is a family member that “sanitizes” oxidized deoxynucleotide triphosphates (dNTP) preventing their incorporation into DNA and thus avoiding DNA damage and cell death.? TH588 inhibits MTH1/NUDT1 (IC50?= 5 nM) leading to cell death in several cancer cell lines while not affecting normal cells.? Active?in vitro?and?in vivo.? Recent evidence has raised doubts about the cancer-killing ability of MTH1 inhibition.2,3?Conversely, TH588 has been also shown to decrease osteosarcoma cell viability, impair cell cycle, and increase apoptosis via an MTH1-dependent pathway.4More related product prices
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Suppliers and manufacturers
career henan chemical co
A.J Chemicals
ATK CHEMICAL COMPANY LIMITED
TargetMol Chemicals Inc.
Zhejiang J&C Biological Technology Co.,Limited
InvivoChem
Coresyn Pharmatech Co., Ltd.
ShenZhen Trendseen Biological Technology Co.,Ltd.
Wuhan Topule Biopharmaceutical Co., Ltd
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd
₹1.00 /1KG
N4-Cyclopropyl-6-(2,3-dichlorophenyl)-2,4-pyrimidinediamine;TH588;N4-cyclopropyl-6-(2,3-dic CAS:1609960-31-7
N4-Cyclopropyl-6-(2,3-dichlorophenyl)-2,4-pyrimidinediamine;TH588;N4-cyclopropyl-6-(2,3-dic CAS:1609960-31-7