ChemicalBook > Product Catalog >Biochemical Engineering >Inhibitors >Neuronal Signaling >Histamine Receptor Inhibitors >Fexofenadine hydrochloride
Fexofenadine hydrochloride
- CAS No.
- 153439-40-8
- Chemical Name:
- Fexofenadine hydrochloride
- Synonyms
- Fexo;Allegra;2-[4-[1-Hydroxy-4-[4-(hydroxy-diphenyl-methyl)-1-piperidyl]-butyl]phenyl]-2-methyl-propanoic acid hydrochloride;Telfast;Alernex;Feksine;Fexofen;Fexadyne;Vivafeks;MDL 16455A
- CBNumber:
- CB0256621
- Molecular Formula:
- C32H40ClNO4
- Molecular Weight:
- 538.13
- MOL File:
- 153439-40-8.mol
- MSDS File:
- SDS
- Modify Date:
- 2025/1/1 17:43:08
| Melting point | 148-150oC |
|---|---|
| RTECS | CY1633377 |
| storage temp. | 2-8°C |
| solubility | Soluble in Dimethyl sulfoxide (50 mM), and methanol. |
| form | powder |
| color | white to beige |
| Merck | 14,4068 |
| InChIKey | RRJFVPUCXDGFJB-UHFFFAOYSA-N |
| CAS DataBase Reference | 153439-40-8(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS08 |
|---|---|
| Signal word | Warning |
| Hazard statements | H317-H360-H312 |
| Precautionary statements | P261-P272-P280-P302+P352-P333+P313-P321-P363-P501-P280-P302+P352-P312-P322-P363-P501 |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36 |
| WGK Germany | 3 |
| HS Code | 2933399090 |
Fexofenadine hydrochloride price More Price(5)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | F9427 | Fexofenadine hydrochloride >98% (HPLC) | 153439-40-8 | 10MG | ₹15523.05 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | PHR1685 | Fexofenadine HCl Pharmaceutical Secondary Standard; Certified Reference Material | 153439-40-8 | 1G | ₹23739.23 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | F9427 | Fexofenadine hydrochloride >98% (HPLC) | 153439-40-8 | 50MG | ₹62211.28 | 2022-06-14 | Buy |
| TCI Chemicals (India) | F0698 | Fexofenadine Hydrochloride | 153439-40-8 | 1G | ₹10600 | 2022-05-26 | Buy |
| TCI Chemicals (India) | F0698 | Fexofenadine Hydrochloride | 153439-40-8 | 5G | ₹11000 | 2022-05-26 | Buy |
Fexofenadine hydrochloride Chemical Properties,Uses,Production
Description
Fexofenadine is a histamine H1 receptor antagonist (Ki = 10 nM). It reverses contraction of isolated rat tracheal strips induced by acetyl-β-methylcholine . Fexofenadine inhibits expression of IL-8 in TNF-α-stimulated HCT116 and COLO 205 cells. Oral administration of fexofenadine (2 and 10 mg/kg) reduces severity of colitis and phospho-IκB kinase activation in a mouse model of colitis induced by dextran sulfate sodium (DSS; ).
Chemical Properties
Off-White Crystalline Solid
Uses
Fexofenadine hydrochloride is used as an antihistamine that inhibits Cox-1, Cox-2, and is a histamine H1 receptor agonist.
General Description
Fexofenadine hydrochloride, (±)-4-[1-hydroxy-4-[4-(hydroxyldiphenylmethyl)- 1-piperinyl]butyl-α,α-dimethylbenzeneacetic acid (Allegra), occurs as a white to off-white crystalline powder that is freely soluble in methanol and ethanol, slightly soluble in chloroform and water, and insoluble in hexane.
This compound is marketed as a racemate and exists as a zwitterion in aqueous media at physiological pH. Fexofenadine is a primary oxidative metabolite of terfenadine. Terfenadine was developed during a search for new butyrophenone antipsychotic drugs as evidenced by the presence of the N-phenylbutanol substituent. It also contains a diphenylmethyl-piperidine moiety analogous to that found in the piperazine antihistamines.
Fexofenadine hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 607)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| TAGOOR LABORATORIES PVT LTD | +919700187008 | AndhraPradesh, India | 90 | 58 | Inquiry |
| HEMA PHARMACEUTICALS PVT LTD | +91-9537936912 +91-9537936912 | Gujarat, India | 48 | 58 | Inquiry |
| Meenaakshi Molecules Pvt Ltd | +91-9121311126 +91-9121311126 | Telangana, India | 45 | 58 | Inquiry |
| Cipla Ltd | +912224826000 | Maharashtra, India | 133 | 58 | Inquiry |
| Chemeca Drugs Private Limited (Vegesna Laboratories Pvt Ltd) | +91-8924236065 +91-9951616502 | AndhraPradesh, India | 48 | 58 | Inquiry |
| Apex Healthcare Limited | +9199825711244 | Gujarat, India | 22 | 58 | Inquiry |
| Hetero Drugs Limited | +91-4023704923 +91-4023704923 | Telangana, India | 296 | 58 | Inquiry |
| Prachi Pharmaceuticals Pvt Ltd | +919004877711 | Mumbai, India | 36 | 58 | Inquiry |
| Macleods Pharmaceuticals Limited | +91-2266762800 +91-2266762800 | Maharashtra, India | 116 | 58 | Inquiry |
| Sam Fine O Chem Limited | +91-9987622299 +91-9987622299 | Maharashtra, India | 93 | 58 | Inquiry |
153439-40-8(Fexofenadine hydrochloride )Related Search:
Fexofenadine
Tribenuron methyl
Methylamine hydrochloride
4-Hydroxyphenylacetic acid
Topotecan hydrochloride
Methoxyammonium chloride
Biphenyl
Butylated hydroxyanisole
PHENYL VALERATE
Triethylamine hydrochloride
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α,α-dimethyl-4-[1-hydroxy-4-[4-(hydroxydiphenylmethyl)-1-piperidinyl]butyl]benzeneacetic acid
Benzeneacetic acid, 4-[1-hydroxy-4-[4-(hydroxydiphenylmethyl)-1-piperidinyl]butyl]-α,α-dimethyl-, hydrochloride
MDL 16455A
Telfast
Telfast BD
Fexofenadine hydrochloride
2-[4-[1-hydroxy-4-[4-[hydroxy(diphenyl)methyl]-1-piperidyl]butyl]phenyl]-2-methyl-propionic acid hydrochloride
FERULICACIDPIPERAZINE
(Carboxyterfenadine-D10,Terfenadinecarboxylate)
Fexofenidine hydrochloride, MDL 16455 hydrochloride, Terfenidine carboxylate hydrochloride
2-[4-[1-hydroxy-4-[4-[hydroxy(diphenyl)methyl]piperidin-1-yl]butyl]phenyl]-2-methylpropanoic acid hydrochloride
2-[4-[1-hydroxy-4-[4-[hydroxy(diphenyl)methyl]piperidin-1-yl]butyl]phenyl]-2-methyl-propanoic acid hydrochloride
Fexofenadine(Hclform)
α,α-Dimethyl-4-[1-hydroxy-4-[4-(hydroxydiphenylmethyl)-1-piperidinyl]butyl]-benzeneaceticacidhydrochloride
Fexofenadine hydrochloride,Fexofenidine hydrochloride, MDL 16455 hydrochloride, Terfenidine carboxylate hydrochloride
2-{4-[(1R)-1-hydroxy-4-[4-(hydroxydiphenylMethyl)piperidin-1-yl]butyl]phenyl}-2-Methylpropanoic acid
4-[1-Hydroxy-4-[4-(hydroxydiphenylMethyl)-1-piperidinyl]butyl]-α,α-diMethylbenzeneacetic Acid Hydrochloride
Alernex
Carboxyterfenadine Hydrochloride
Feksine
Fexadyne
Fexofen
Terfenadinecarboxylate Hydrochloride
Vivafeks
(R)-2-(4-(1-hydroxy-4-(4-(hydroxydiphenylMethyl)piperidin-1-yl)butyl)phenyl)-2-Methylpropanoic acid hydrochloride
2-(4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butyl)phenyl)-2-methylpropanoic acid h
Benzeneaceticacid, 4-[1-hydroxy-4-[4-(hydroxydiphenylMethyl)-1-piperidinyl]butyl]-a,a-diMethyl-,hydrochloride (1:1)
feofenadine hydrochloride
2-(4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butyl)phenyl)-2-methylpropanoic aci
FEXOFENADINE-D10 HCL
(138452-21-8) fexofenadine hydrochloride
Non - Determination of hydrochloride
FexofenadineHydrochloride>
Fexofenadine Hydrochloride RS
Fexofenadine hydrochloride CRS
Fexofenadine hydrochloride b
Fexofenadine hydrochloride Fexofenadine hcl
Fexofenadine hydrochloride USP/EP/BP
Fexofenadine hydrochloride salt
Fexofenadine Hydrochloride (Y000789)Q: What is
Fexofenadine Hydrochloride (Y000789) Q: What is the CAS Number of
Fexofenadine Hydrochloride (Y000789)
Fexofenadine HydrochlorideQ: What is
Fexofenadine Hydrochloride Q: What is the CAS Number of
Fexofenadine Hydrochloride Q: What is the storage condition of
Fexofenadine Hydrochloride Q: What are the applications of
Fexofenadine Hydrochloride
153439-40-8 Fexofenadine hydrochloride
Fexofenadine Hydrochloride (1270377)
2-[4-[1-Hydroxy-4-[4-(hydroxy-diphenyl-methyl)-1-piperidyl]-butyl]phenyl]-2-methyl-propanoic acid hydrochloride
Allegra
Fexo
Fexofenadine Hydrochloride IP/USP/Ph. Eur/BP
Fexofenadine Hydrochloride IP/BP/USP/EP
Fexofenadine Hydrochloride, ≥ 98.0%
Fexofenadine hydrochloride, H1 receptor antagonist
153439-40-8
C32H29D10NO4HCl
C32H39NO4ClH
C32H39NO4xHCl
C32H40ClNO4
C32H39ClNO4
API
Aromatics