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Terfenadine

CAS No.: 50679-08-8

Chemical Name:: Terfenadine

Synonyms: seldane;Terfenadin;Cyater;Terdin;terfen;Terfex;Aldaban;mdl9918;rmi9918;Teldane

CBNumber:: CB7695393

Molecular Formula:: C32H41NO2

Molecular Weight:: 471.67

MOL File:: 50679-08-8.mol

Modify Date:: 2024/7/2 8:55:17

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Terfenadine Properties

Melting point	145-152 °C
Boiling point	572.76°C (rough estimate)
Density	1.0488 (rough estimate)
refractive index	1.6310 (estimate)
storage temp.	2-8°C
solubility	chloroform: soluble250 mg plus 5 ml of solvent, clear to very slightly hazy, colorless to faintly yellow
form	Solid
pka	pKa 9.21(H2O t = 25 I = 0.025) (Uncertain)
color	White to Off-White
Water Solubility	0.001 g/100 mL (30 ºC)
CAS DataBase Reference	50679-08-8(CAS DataBase Reference)
NIST Chemistry Reference	Seldane(50679-08-8)

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07,GHS08,GHS09
Signal word	Danger
Hazard statements	H413
Precautionary statements	P273-P501
Safety Statements	24/25
WGK Germany	2
RTECS	TM4969000
HS Code	29333999
Toxicity	LD50 orally in mice: >2000 mg/kg (Carr, Meyer)

Terfenadine price More Price(2)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich(India)	T9652	Terfenadine	50679-08-8	5G	₹10857.48	2022-06-14	Buy
Sigma-Aldrich(India)	T9652	Terfenadine	50679-08-8	25G	₹42867	2022-06-14	Buy

Product number	Packaging	Price	Buy
T9652	5G	₹10857.48	Buy
T9652	25G	₹42867	Buy

Terfenadine Chemical Properties,Uses,Production

Chemical Properties

White Solid

Uses

Terfenadine has been used to study the role of histamine in itch related to proteinase-activated receptors (PARs) in mice. Terfenadine has also been used to block histamine receptor type 1 to study the pathogenesis of 2,4-dinitrobenzene sulfonic acid (DNBS)-induced ulcerative colitis in rats.

World Health Organization (WHO)

The first clinically interesting histamine H-receptor1 antagonists were introduced in the late 1940s and early 1950s. Several H-antihistaminics have a similar cardiac effect to that seen with astemizole1 and terfenadine. Serious cardiovascular adverse reactions have been reported when used concomitantly with imidazole antifungals and macrolide antibiotics. See also under astemizole.

Biological Activity

Histamine H 1 receptor antagonist. Also blocks hERG and K ATP channels (IC 50 values are 204 nM and 1.2 μ M respectively). Inhibits the delayed rectifier K + current (I Kr ) in guinea pig ventricular myocytes (IC 50 = 50 nM). Activity prolongs QT and induces Torsades de pointes (TdP); cardiotoxic in vivo .

Pharmacology

Terfenadine not only differs from the other antihistamine drugs in its chemical structure, but also in that its action begins within 1–2 h and last approximately 12 h, reaching its peak of action in 3–4 h.

Terfenadine Preparation Products And Raw materials

Raw materials

Isobutylbenzene DE Potassium hydroxide Potassium iodide Acetone

alpha,alpha-Diphenyl-4-piperidinomethanol Potassium bicarbonate Toluene 4-Chlorobutyryl chloride Sodium borohydride

4-Piperidinemethanol Aluminum chloride Difenidol hydrochloride Hydrochloric acid Potassium borohydride

Methanol Hydrogen chloride ether solution Isopropyl alcohol

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Preparation Products

Terfenadine Suppliers

Global( 203)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
CLEARSYNTH LABS LTD.	+91-22-45045900	Hyderabad, India	6351	58	Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd	+91-172-5066494	Haryana, India	6773	58	Inquiry
OCEAN TRADING CORPORATION	+91(22) 24921669	New Delhi, India	6211	58	Inquiry
Medilink Pharmachem	+91 (79) 3007-0133	New Delhi, India	424	50	Inquiry
Hangzhou FandaChem Co.,Ltd.	008657128800458; +8615858145714	China	9337	55	Inquiry
CONIER CHEM AND PHARMA LIMITED	+8618523575427	China	49391	58	Inquiry
career henan chemical co	+86-0371-86658258 +8613203830695	China	29826	58	Inquiry
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	United States	19892	58	Inquiry
Hefei TNJ Chemical Industry Co.,Ltd.	0551-65418671	China	34571	58	Inquiry
Shaanxi Dideu Medichem Co. Ltd	+86-029-89586680 +86-18192503167	China	9030	58	Inquiry

Supplier	Advantage
CLEARSYNTH LABS LTD.	58
Pharmaffiliates Analytics and Synthetics P. Ltd	58
OCEAN TRADING CORPORATION	58
Medilink Pharmachem	50
Hangzhou FandaChem Co.,Ltd.	55
CONIER CHEM AND PHARMA LIMITED	58
career henan chemical co	58
TargetMol Chemicals Inc.	58
Hefei TNJ Chemical Industry Co.,Ltd.	58
Shaanxi Dideu Medichem Co. Ltd	58

Terfenadine Spectrum

Terfenadine(50679-08-8)¹HNMR

50679-08-8(Terfenadine)Related Search:

Diphenylsilane Diphenylphosphine Chlorodiphenylphosphine PHENYL VALERATE Diphenyldimethoxysilane

Dichlorodiphenylsilane Diphenylmethane tert-Butylchlorodiphenylsilane 1,3-Diphenyl-2-thiourea Cetirizine

Levoceitrizine Hcl Loratadine Ebastine FEXOFENADINE HYDROCHLORIDE Fexofenadine hydrochloride

Terfenadine caroxylate,Terfenadine acid TERFENADINE IMP.I (EP):DIPHENYL(PIPERIDIN-4-YLMETHANOL(AZACYCLONOL) Phenylacetic acid

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TERFENADINE a-[4-(1,1-Dmethylethyl)phenyl]-4-(hydroxydiphenylmethyl)-1-piperidinebutanol A1lerplus Triludma ALPHA-[4-(1,1-DIMETHYLETHYL)PHENYL]-4-(HYDROXYDIPHENYLMETHYL)-1-PIPERIDINEBUTANOL 1-(p-tert-Butylphenyl)-4-(4'-(alpha-hydroxydiphenylmethyl)-1'-piperidyl)-butanol (R)-α-[4-(1,1-Dimethylethyl)phenyl]-4-(hydroxydiphenylmethyl)-1-piperidine-1-butanol [R,(+)]-α-[4-(1,1-Dimethylethyl)phenyl]-4-(hydroxydiphenylmethyl)-1-piperidine-1-butanol (S)-α-[4-(1,1-Dimethylethyl)phenyl]-4-(hydroxydiphenylmethyl)-1-piperidine-1-butanol [S,(-)]-α-[4-(1,1-Dimethylethyl)phenyl]-4-(hydroxydiphenylmethyl)-1-piperidine-1-butanol α-(p-tert-Butylphenyl)-4-(hydroxydiphenylmethyl)-1-piperidine-1-butanol Terfenadine (200 mg) Terfenadine, Seldane, Triludan, Teldane Terfenadine 5GR α-[4-(1,1-DMethylethyl)phenyl]-4-(hydroxydiphenylMethyl)- Trerfenadine Fexofenadine / MDL 16455 1-(4-(tert-Butyl)phenyl)-4-(4-(hydroxydiphenylmethyl)-piperidin-1-yl)butan-1-ol α-[4-(1,1-dimethylethyl)phenyl]-4-(hydroxydiphenylmethyl)-1-piperidinebutanol TERFENADINE(SUBJECTTOPATENTFREE) 1-Piperidinebutanol, a-[4-(1,1-dimethylethyl)phenyl]-4-(hydroxydiphenylmethyl)- (9CI) a-(p-tert-Butylphenyl)-4-(a-hydroxy-a-phenylbenzyl)-1-piperidinebutanol dl-Terfenadine Histadin NSC 665802 Racemic terfenadine 1-(4-tert-butylphenyl)-4-(4-(hydroxydiphenylmethyl)piperid-1-yl)butan-1-ol Terfenadine (Patent No Supply) 3-[2-Thienyl]-L-Alanine99.5% A3，5-Diethoxy Acetopheone 1-(4-tert-butylphenyl)-4-(4-(alpha-hydroxybenzhydryl)piperidino)-butan-1-ol 1-(4-tert-Butylphenyl)-4-(4-[hydroxy(diphenyl)methyl]-1-piperidinyl)-1-butanol 1-(p-tert-butylphenyl)-4-(4’-(alpha-hydroxydiphenylmethyl)-1’-piperidyl)-butan 1-Piperidinebutanol, alpha-[4-(1,1-dimethylethyl)phenyl]-4-(hydroxydiphenylmethyl)- 1-piperidinebutanol,alpha-(4-(1,1-dimethylethyl)phenyl)-4-(hydroxydiphenylmeth Aldaban Allerplus alpha-(4-(1,1-dimethylethyl)phenyl)-4-(hydroxydiphenylmethyl)-1-piperidinebu alpha-(4-(1,1-dimethylethyl)phenyl)-4-(hydroxydiphenylmethyl)-1-piperidinebuta alpha-(p-tert-butylphenyl)-4-(alpha-hydroxy-alpha-phenylbenzyl)-1-piperidinebu alpha-(p-tert-Butylphenyl)-4-(hydroxydiphenylmethyl)-1-piperidinebutanol Cyater mdl9918 MDL-9918 Nebralin RMI 9918 rmi9918 rmi-9918 Teldane Teldanex Terdin terfen terfenadina(inn-spanish) terfenadinum(inn-latin) Terfex Ternadin treludan Triludan