N-Acetyl-D-Glucosamine
- CAS No.
- 7512-17-6
- Chemical Name:
- N-Acetyl-D-Glucosamine
- Synonyms
- N-ACETYLGLUCOSAMINE;D-GLCNAC;acetylglucosamine;2-Acetamido-2-deoxy-D-glucopyranose;Acetyl chitin;N-Acetyl-D-glucosamin;N-ACETYL-D-GLUCOSAMINIDE;N-Acetyl-beta-D-glucosamine;2-ACETAMIDO-2-DEOXY-D-GLUCOSE;NADG
- CBNumber:
- CB0320700
- Molecular Formula:
- C8H15NO6
- Molecular Weight:
- 221.21
- MOL File:
- 7512-17-6.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/6/6 16:20:44
| Melting point | 211 °C (dec.) (lit.) |
|---|---|
| alpha | 42 º (c=2,water,2 hrs) |
| vapor pressure | 8Pa at 20℃ |
| refractive index | +39.0 to +42.0 ° (C=1, H2O) |
| storage temp. | -20°C |
| solubility | Soluble in concentrated hydrochloric acid, sulfuric acid, phosphoric acid and formic acid. Insoluble in water, dilute acids, dilute alkalis, concentrated alkalis and organic solvents. |
| form | saline suspension |
| Boiling point | 636.4±55.0 °C(Predicted) |
| Density | 1.54 g/cm3 |
| pka | 13.04±0.20(Predicted) |
| color | white to off-white |
| Water Solubility | H2O: 50 mg/mL colorless to faint yellow solution, clear to very slightly hazy |
| Sensitive | Hygroscopic |
| Merck | 14,4458 |
| BRN | 1727589 |
| Stability | Stable. Incompatible with strong oxidizing agents. |
| InChIKey | OVRNDRQMDRJTHS-ROGOILFBSA-N |
| LogP | -2.2 at 23.7℃ |
| CAS DataBase Reference | 7512-17-6(CAS DataBase Reference) |
| EPA Substance Registry System | N-Acetylglucosamine (7512-17-6) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS05 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H314 | |||||||||
| Precautionary statements | P280-P305+P351+P338-P310 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 24/25-36-26-22 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | LZ6651000 | |||||||||
| F | 3-10 | |||||||||
| Hazard Note | Irritant | |||||||||
| TSCA | Yes | |||||||||
| HS Code | 29329985 | |||||||||
| NFPA 704 |
|
N-Acetyl-D-Glucosamine price More Price(25)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | A8625 | N-Acetyl-D-glucosamine ≥99% | 7512-17-6 | 10MG | ₹3020.18 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | PHR1432 | N-Acetylglucosamine Pharmaceutical Secondary Standard; Certified Reference Material | 7512-17-6 | 1G | ₹9103.83 | 2022-06-14 | Buy |
| Sigma-Aldrich | A8625 | N-Acetyl-D-glucosamine ≥99% | 7512-17-6 | 5G | ₹13163.2 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | A8625 | N-Acetyl-D-glucosamine ≥99% | 7512-17-6 | 5G | ₹13163.2 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | A8625 | N-Acetyl-D-glucosamine ≥99% | 7512-17-6 | 25G | ₹35754.98 | 2022-06-14 | Buy |
N-Acetyl-D-Glucosamine Chemical Properties,Uses,Production
Description
N-Acetyl-D-Glucosamine is the N-acetyl derivative of glucosamine.Chemically it is an amide between glucosamine and acetic acid. A single N-acetlyglucosamine moiety linked to serine or threonine residues on nuclear and cytoplasmic proteins -O-GlcNAc, is an ubiquitous post-translational protein modification. O-GlcNAc modified proteins are involved in sensing the nutrient status of the surrounding cellular environment and adjusting the activity of cellular proteins accordingly. O-GlcNAc regulates cellular responses to hormones such as insulin, initiates a protective response to stress, modulates a cell's capacity to grow and divide, and regulates gene transcription. In humans, it exists in skin, cartilage and blood vessel as a component of hyaluronic acid, and bone tissue, cornea and aorta as a component of keratan sulfate.
N-Acetyl-D-glucosamine (D-GlcNAc) is a derivitized glucose monomer found in polymers of bacterial cell walls, chitin, hyaluronic acids and various glycans. It is also synthesized in the glycosylation pathway as uridine diphosphate (UDP-GlcNAc), which can then be released following degradation of glycosylated proteins.D-GlcNAc is used to identify, differentiate and characterize N-acetyl-β-D-hexoaminidase(s). It is also used in the treatment of osteoarthritis and inflammatory bowel disease (IBD), including ulcerative colitis and Crohn's disease. Further, it is used as a substrate in sialic acid production, cosmetics and in drug development research.
Chemical Properties
White powder
Uses
N-Acetyl-D-glucosamine is used in the identification and characterization of N-acetyl-beta-D-hexoaminidase. It is also used in the treatment of osteoarthritis and inflammatory bowel disease (IBD), including ulcerative colitis and Crohn's disease. Further, it is used as a substrate in sialic acid production, cosmetics and in drug development research.
Definition
ChEBI: N-acetyl-D-glucosamine is the D isomer of N-acetylglucosamine. It has a role as a bacterial metabolite. It is a N-acetylglucosamine and a N-acetyl-D-hexosamine.
General Description
N-Acetylglucosamine (GlcNAc) is a monosaccharide, derived from glucose and undergoes linear polymerization by (1,4)-β-linkages to form the polymer chitin. It is also a component of heterogenous polysaccharides, such as murein and hyaluronic acid. N-acetylglucosamine exhibits anti-inflammatory properties and is considered as a potential drug in the treatment of osteoarthritis. Its antiarthritic mode of mechanism involves the suppression of IL-1β (Interleuken-1β)-induced NO (nitric oxide), cyclooxygenase-2 (COX-2), and IL-6 production by inhibition of expression of iNOS (inducible nitric oxide synthase) protein and mRNA.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
N-Acetyl-D-Glucosamine Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Meck Pharmaceuticals and Chemicals Pvt. Ltd. | +91-9898053709 +91-9898540709 | Gujarat, India | 44 | 58 | Inquiry |
| R N Laboratories Pvt Ltd | 26472226736677 | Maharashtra, India | 10 | 58 | Inquiry |
| SIDDHI VINAYAKA SPECHEM PVT LTD | +91-9886203493 +91-9845072402 | Karnataka, India | 41 | 58 | Inquiry |
| Acorn Chemicals Pvt. Ltd. | 91-22-22818122 | Maharashtra, India | 22 | 58 | Inquiry |
| HiMedia Laboratories | 91-22-61471919 | Maharashtra, India | 1843 | 58 | Inquiry |
| Brisben Chemicals | 08048963750 | Mumbai, India | 509 | 58 | Inquiry |
| Pharmed Medicare (P) Ltd. | +91 80 841 0158 | New Delhi, India | 71 | 65 | Inquiry |
| CHEMSWORTH | +91-261-2397244 | New Delhi, India | 6707 | 30 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| Meck Pharmaceuticals and Chemicals Pvt. Ltd. | 58 |
| R N Laboratories Pvt Ltd | 58 |
| SIDDHI VINAYAKA SPECHEM PVT LTD | 58 |
| Acorn Chemicals Pvt. Ltd. | 58 |
| HiMedia Laboratories | 58 |
| Brisben Chemicals | 58 |
| Pharmed Medicare (P) Ltd. | 65 |
| CHEMSWORTH | 30 |
| A.J Chemicals | 58 |
| CLEARSYNTH LABS LTD. | 58 |
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