Acesulfame potassium
- CAS No.
- 55589-62-3
- Chemical Name:
- Acesulfame potassium
- Synonyms
- ACESULFAME K;acesulfame;ACESULPHAMEPOTASSIUM;RARECHEM AM UC 0205;SWEET ONE;ACESULPHAME-K;ASPARTAMEACESULPHAMESALT;Acesulfame potassium CRS;ACESULFAME POTASSIUM SALT;Ansai
- CBNumber:
- CB3224119
- Molecular Formula:
- C4H4KNO4S
- Molecular Weight:
- 201.24
- MOL File:
- 55589-62-3.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/7/2 8:55:06
| Melting point | 229-232°C (dec.) |
|---|---|
| Boiling point | 210℃[at 101 325 Pa] |
| Density | (solid) 1.81 g/cm3; d (bulk) 1.1-1.3 kg/dm3 |
| vapor pressure | 0.291Pa at 25℃ |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | Soluble in water, very slightly soluble in acetone and in ethanol (96 per cent). |
| form | Solid |
| color | White crystalline solid |
| Odor | odorless with sweet taste |
| Odor Type | odorless |
| Water Solubility | almost transparency |
| Merck | 14,37 |
| BRN | 3637857 |
| LogP | -2.35 at 23℃ |
| CAS DataBase Reference | 55589-62-3(CAS DataBase Reference) |
| EPA Substance Registry System | Acesulfame-potassium (55589-62-3) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319 |
| Precautionary statements | P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313 |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36/37/39 |
| WGK Germany | 1 |
| RTECS | RP4489165 |
| HS Code | 2934990002 |
| Toxicity | LD50 in rats (mg/kg): 7431 orally, 2243 i.p. (Mayer, Kemper) |
Acesulfame potassium price More Price(6)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | 04054 | Acesulfame K for food analysis, ≥99.0% | 55589-62-3 | 25G | ₹8930.63 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | PHR1266 | Acesulfame K Pharmaceutical Secondary Standard; Certified Reference Material | 55589-62-3 | 500MG | ₹9818.28 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 04054 | Acesulfame K for food analysis, ≥99.0% | 55589-62-3 | 100G | ₹24724.3 | 2022-06-14 | Buy |
| TCI Chemicals (India) | A1490 | Acesulfame K | 55589-62-3 | 25G | ₹3700 | 2022-05-26 | Buy |
| TCI Chemicals (India) | A1490 | Acesulfame K | 55589-62-3 | 100G | ₹4200 | 2022-05-26 | Buy |
Acesulfame potassium Chemical Properties,Uses,Production
Description
Acesulfame potassium is approved for use in food as a sweetener. It is included in the ingredient list on the food label as acesulfame K, acesulfame potassium, or Ace-K. Acesulfame potassium (Ace-K) is regulates as a food additive. The FDA approved acesulfame potassium for use in specific food and beverage categories in 1988 and in 2003 approved it as a general-purpose sweetener and flavor enhancer in food, except in meat and poultry, under certain conditions of use. It is widely used in the food industry, such as mouthwash and soft drinks. However, some researches have found that it does harm to the liver and nervous system[1-2].
Chemical Properties
Acesulfame potassium occurs as a colorless to white-colored, odorless, crystalline powder with an intensely sweet taste.
History
Acesulfame-K, the potassium salt of acesulfame, is a sweetener that resembles saccharin in structure and taste profile. 5,6-Dimethyl-1,2,3-oxathiazine-4(3H)-one 2,2-dioxide, the first of many sweet compounds belonging to the dihydrooxathiazinone dioxide class, was discovered accidentally in 1967. From these many sweet compounds, acesulfame was chosen for commercialization. To improve water solubility, the potassium salt was made. Acesulfame-K (Sunett) was approved for dry product use in the United States in 1988 and in Canada in October, 1994. In 2003, acesulfame-K was approved as a general purposes sweetener by the FDA.
Uses
'New generation', heat-stable sweetener that has not been suspected to cause cancer nor be genotoxic. Allelic variation of the Tas1r3 gene affects behavioral taste responses to this molecule, suggesting that it is a T1R3 receptor ligand.
Production Methods
Acesulfame potassium is synthesized from acetoacetic acid tertbutyl
ester and fluorosulfonyl isocyanate. The resulting compound
is transformed to fluorosulfonyl acetoacetic acid amide, which is
then cyclized in the presence of potassium hydroxide to form the
oxathiazinone dioxide ring system. Because of the strong acidity of
this compound, the potassium salt is produced directly.
An alternative synthesis route for acesulfame potassium starts
with the reaction between diketene and amidosulfonic acid. In the
presence of dehydrating agents, and after neutralization with
potassium hydroxide, acesulfame potassium is formed.
brand name
Sunett? and Sweet One?
Pharmaceutical Applications
Acesulfame potassium is used as an intense sweetening agent in
cosmetics, foods, beverage products, table-top sweeteners, vitamin
and pharmaceutical preparations, including powder mixes, tablets,
and liquid products. It is widely used as a sugar substitute in
compounded formulations,and as a toothpaste sweetener.
The approximate sweetening power is 180–200 times that of
sucrose, similar to aspartame, about one-third as sweet as sucralose,
one-half as sweet as sodium saccharin, and about 4-5 times sweeter
than sodium cyclamate.It enhances flavor systems and can be
used to mask some unpleasant taste characteristics.
Biological Activity
In rats, Acesulfame potassium (AceK) consumption from in-utero to post-weaning stages accelerated puberty onset, accompanied by increased brain gonadotropin-releasing hormone (GnRH) expression. Intracerebroventricular AceK injection also induced early puberty onset in rats. In N44 hypothalamic neuron cells, AceK treatment increased reactive oxygen species production, which led to protein kinase A (PKA) activation and increased GnRH expression[1].
Safety Profile
When heated to decompositionemits toxic fumes of SOx.
Safety
Acesulfame potassium is widely used in beverages, cosmetics, foods,
and pharmaceutical formulations, and is generally regarded as a
relatively nontoxic and nonirritant material. Pharmacokinetic
studies have shown that acesulfame potassium is not metabolized
and is rapidly excreted unchanged in the urine. Long-term feeding
studies in rats and dogs showed no evidence to suggest acesulfame
potassium is mutagenic or carcinogenic.
The WHO has set an acceptable daily intake for acesulfame
potassium of up to 15 mg/kg body-weight.The Scientific
Committee for Foods of the European Union has set a daily intake
value of up to 9 mg/kg of body-weight.
LD50 (rat, IP): 2.2 g/kg
LD50 (rat, oral): 6.9–8.0 g/kg
storage
Acesulfame potassium possesses good stability. In the bulk form it
shows no sign of decomposition at ambient temperature over many
years. In aqueous solutions (pH 3.0–3.5 at 208℃) no reduction in
sweetness was observed over a period of approximately 2 years.
Stability at elevated temperatures is good, although some decomposition
was noted following storage at 408℃ for several months.
Sterilization and pasteurization do not affect the taste of acesulfame
potassium.
The bulk material should be stored in a well-closed container in a
cool, dry place and protected from light.
Regulatory Status
Included in the FDA Inactive Ingredients Database for oral and sublingual preparations. Included in the Canadian List of Acceptable Non-medicinal Ingredients. Accepted for use in Europe as a food additive. It is also accepted for use in certain food products in the USA and several countries in Central and South America, the Middle East, Africa, Asia, and Australia.
References
[1] Wu H, et al. Consumption of the nonnutritive sweetener acesulfame potassium increases central precocious puberty risk. Journal of Hazardous Materials, 2023; 461: 132529.
[2] Duan X, et al. Detection of acesulfame potassium in mouthwash based on surface-enhanced Raman spectroscopy. Optical Engineering, 2018; 57: 057102 .
Acesulfame potassium Preparation Products And Raw materials
Raw materials
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| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| HRV Global Life Sciences | +91-9820219686 +91-9820219686 | Telangana, India | 379 | 58 | Inquiry |
| Ralington Pharma | +91-7948911722 +91-9687771722 | Gujarat, India | 1350 | 58 | Inquiry |
| Gangwal Healthcare Pvt Ltd | +91-9320779960 | Maharashtra, India | 51 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| Prado Chemical | 08048979013 | Mumbai, India | 25 | 58 | Inquiry |
| Vardhaman Healthcare (A Division of Vardhaman... | 08048958884 | Ahmedabad, India | 26 | 58 | Inquiry |
| M/s Silaris Ingredients LLP | 08048958226 | Mumbai, India | 4 | 58 | Inquiry |
| Dharam Biotech Private Limited | 08048617130 | Mumbai, India | 5 | 58 | Inquiry |
| Akhil Healthcare Private Limited | 08046060620 | Vadodara, India | 78 | 58 | Inquiry |
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